Young Hwan Chang

Excited to share our new bioRxiv. By integrating MTI, agent-based modeling, and state-space analysis, we define tumor-immune trajectory context in TNBC and show that treatment-phase TME states robustly predict immunotherapy response: biorxiv.org/content/10.648…

Congratulations to Sandhya on being featured at SPIE Medical Imaging! linkedin.com/posts/spie_spi…

🚨 New Preprint Alert! 📄 miniMTI: Minimal multiplex tissue imaging enhances biomarker prediction from histology 🔗 lnkd.in/gcgxuwBh We use discrete tokenization + masked language modeling to jointly model H&E and multiplex markers.

Excited to speak this weekend at the Vanderbilt Symposium on #AI, #Spatial & Systems Biology 2025—hosted by @KenLauLab and @tae_hwang at @VanderbiltU’s Center for Computational Systems Biology. 🌟A stellar speaker lineup! Agenda: vanderbilt.edu/computational-… Onsite full—join virtually

Looking forward to the Vanderbilt Symposium on AI + Spatial Systems Biology 2025 next week! I will be presenting our recent advances in this space. vanderbilt.edu/computational-…

Excited to be at #MICCAI2025 next week! 🎉 With Zachary Sims, we’ll present “Language of Stains: Tokenization Enhances Multiplex Immunofluorescence and Histology Image Synthesis” 👉 link.springer.com/chapter/10.100… Let’s connect if you’re there!

@neurospy sorry - here is correct one: sciencedirect.com/science/articl…

@QBI_Lab_OHSU Link doesn’t work

Multiplex tissue imaging needs robust normalization. UniFORM preserves biological signals while correcting batch effects—feature- and pixel-level, platform-agnostic, Python-based: doi.org/10.1016/j.crme…

Exciting news! 🎉 Our invention, “Translation of images of stained biological material,” has been issued. AI turns routine stains (H&E) into virtual specialized stains → faster, more accessible tissue analysis. patents.google.com/patent/US12327…

COEXIST — a new algorithm to align serial multiplex tissue imaging (MTI) sections at single-cell resolution. By integrating spatial + molecular features, COEXIST overcomes biological heterogeneity to unlock deeper insights into the tumor microenvironment. doi.org/10.1371/journa…

Really excited to share our new @CellPressNews Cell paper with Elana Fertig and colleagues. 1/n cell.com/cell/fulltext/… @theNCI @NIH @JKTGFoundation @mathoncoblog @SMB_MathBiology @IUBloomington @IULuddy @BCRFcure

Congrats Eun-Na! We found that inflammation patterns in artery disease (AAA) differ based on CRP protein deposits. Multiplex tissue imaging showed how immune cells change, pointing to new treatment ideas. doi.org/10.1016/j.trsl…

Automated Quality Control of Time-Course Imaging from 3D in vitro cultures biorxiv.org/content/10.110… #biorxiv_bioeng

These speakers from @OHSUNews will focus on cutting-edge research that is using #AI and #MachineLearning techniques to advance our knowledge of both diagnostics and mechanisms that drive disease! See the full #Pathobiology2025 program bit.ly/3yOeuxu

Our recent work "Learning a Language of Stains" was presented as a poster at NVIDIA GTC 2025 nvidia.com/gtc/posters/?s…

Our new paper is out, and @zacpdx will be presenting it at #GTC next week. Language of Stains: Tokenization Enhances Multiplex Immunofluorescence and Histology Image Synthesis biorxiv.org/content/10.110…

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon febs.onlinelibrary.wiley.com/doi/full/10.10…

@tae_hwang @VUMChealth @VanderbiltU Congratulations!!

Excited to start my new role as Founding Director of the Center for Molecular AI, Director of AI Research in Surgical Sciences, & Endowed Chair at @VUMChealth and @VanderbiltU ! Excited to lead AI-driven innovations in biology & medicine to improve patient care. #AI #Innovation #PrecisionMedicine

UniFORM: Towards Universal Immunofluorescence Normalization for Multiplex Tissue Imaging biorxiv.org/content/10.110…

@tae_hwang @NCIHTAN @MayoClinic @MayoCancerCare @MayoClinicSOM Congrats Dr. Hwang!

Excited to co-lead the Gastric Pre-Cancer #HumanTumorAtlas @NCIHTAN project. Our lab at @MayoClinic @MayoCancerCare @MayoClinicSOM is developing cutting-edge 3D tumor imaging and generating single cell and spatial comics data to drive AI-powered 3D molecular tumor modeling. Working with @DrMingyaoLi @PennMedicine & @IamLinghua @MDAndersonNews, we are focused on understanding how gastric pre-cancer forms, develops into cancer, and responds to treatments, leading to better treatment strategies. Thrilled to collaborate with my friend @SamWangMD @UTSW_Surgery @utswcancer @JeremyLDavisMD @theNCI @MansfieldPaul @MDAndersonNews & partners like @moofaca @Tomocubeinc @10xGenomics @BioActs @SingularGenomic @AkoyaBio for next-gen 3D molecular imaging, single cell, spatial comics. We are alwaysing looking for people to join our journe to end cancer togehter. Interested, please DM or send an email to hwang.taehyun@mayo.edu. hwanglab.org #CancerMoonshot #HTAN #NCI #GastricCancer #PrecisionOncology