Ken Lau Lab

Excited to share our latest work published in @Nature, by grad student @mirazul302, currently on the job market. We uncovered clonal dynamics relating normal to tumor cells using natural and synthetic genetic changes. #SingleCell #DevBio #CRISPR #CRC #HTAN nature.com/articles/s4158…

@DecMcCole @jclinicalinvest @VUMChealth @harrypotter Awesome. Thank you Declan. A pleasure to read.

Thrilled to write this commentary in @jclinicalinvest on a great study from @KenLauLab & team @VUMChealth identifying an unexpected role for goblet cells in region specific intestinal inflammation. Yes, the title choice was inspired by my daughter’s love of @harrypotter books!

Location, location, location—in Inflammatory bowel disease (#IBD) doi.org/10.1172/JCI201… Paige N. Spencer @Paige_N_Spencer, Monica E. Brown @moni_e_brown, Ken S. Lau @KenLauLab & team @VUMChealth determine how chronic inflammatory disease can manifest in a region-specific fashion, providing a unique model of #Crohn’s disease that reveals #Chlamydia and genetic risk as a trigging combination for Crohn’s disease-like inflammation in the proximal colon. The image shows the host-pathobiont interface in the inflamed murine proximal colon, where intracellular Chlamydia muridarum (MOMP; green) in epithelial cells induces goblet cell-specific expression of indoleamine 2,3-dioxygenase 1 (IDO1; magenta); nuclei (blue). Image credit: Monica Brown, Paige Spencer, and William Kim.

medschool.vanderbilt.edu/basic-sciences… @HelmsleyTrust @NIDDKgov @hhmi_science

Shoutouts to the collaborators and groups that made this project possible: @valdi001 @Wenhan_Zhu1 @jeremygoettel @Dr_LoriCoburn @moni_e_brown @VUBasicSciences @VanderbiltCDB #inflammation #microbiome #Crohnsdisease #IBD

Why does Crohn’s disease affect different regions of the GI tract? @Paige_N_Spencer tackled this in our latest study (in press @jclinicalinvest), uncovering region-specific responses that drive inflammation in the PROXIMAL colon to a pathobiont. 🔬🧬 jci.org/articles/view/…

@Aiims1742 @Perlmutter_CC @nyulangone @JohnPLeonardMD @nyugrossman @NYULangoneLI @NYULangoneBK @DrOscarLahoud @EmelineAvikiMD Congratulations!

I am honored to serve as the new Director of the @Perlmutter_CC. Thanks to Dean/CEO Alec Kimmelman @nyulangone for this opportunity. Excited to partner with @JohnPLeonardMD & the entire PCC community as we build our next exciting chapter. Lots to come! prnewswire.com/news-releases/…

Happy Holidays to all! Hope we can overcome the challenges of the past year in the coming New Year! (courtesy of @w_janney)

Vanderbilt Symposium on AI, Spatial & Systems Biology 2025. Thank you all for coming out on the weekend! @VUBasicSciences. Key note: Dr. Jonathan Liu from Stanford on hybrid open top light sheet microscopy!

Excited to speak this weekend at the Vanderbilt Symposium on #AI, #Spatial & Systems Biology 2025—hosted by @KenLauLab and @tae_hwang at @VanderbiltU’s Center for Computational Systems Biology. 🌟A stellar speaker lineup! Agenda: vanderbilt.edu/computational-… Onsite full—join virtually

@DelgiornoKathy Congratz

Happy Birthday Brody! 8/16/25

@JudithAgudo1 @nyscf @DanaFarberNews @harvardmed @parkerici Congratz

Thanks to the people in my lab, my mentors and collaborators. And the sources of funding that launched my lab @nyscf @DanaFarberNews @harvardmed @parkerici and the DoD breast cancer program.

So glad to be spending a few days with @SKDevStemCell @SK_GGB @SickKidsNews to share great science and friendship! Beautiful Blue Mountain Venue.

Congratulations to @K_Harsim from @KenLauLab for winning the Poster Prize at the Beatson International Cancer Conference 2025! Thanks to @MolOncology for sponsoring this prize #BICC2025

Thank you to @CRUK_SI and @DrPipDunne for a wonderful experience in Scotland for #BICC2025. Congratz to @K_Harsim for receiving the outstanding poster award!