Wansang Cho

I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo. A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models. #Ack1" target="_blank" rel="nofollow noopener">nature.com/articles/s4158… a 🧵

Today we report single-cell APEX-seq (scAPEX-seq) — a new method for unbiased mapping of *subcellular* transcriptomes at single-cell resolution. This approach reveals cell states that are not detectable by standard scRNA-seq, and enabled us to identify regulators of CAR T function that improve solid tumor killing. biorxiv.org/cgi/content/sh…

Check out the video interview 🎥 highlighting our work on programmable JAK/STAT signaling to design improved CAR T cell therapies! 🧬🧫

On the #AACRBlog: Read about three studies from #AACRio26 that leverage innovative science to give the immune system a better chance against cancer. brnw.ch/21x0BVo @idibaps @Stanford @MIT @ScienceWansang @MegTriesScience

Review @Cancer_Cell @MiriamMerad @SinaiImmunol Macrophages: Targets for next-generation cancer immunotherapy cell.com/cancer-cell/fu…

Thanks, Gabe!

Also, I am grateful for the Scholar-in-training award at #AACRIO2026! Many congratulations to the fellow awardees 👏

Owen N. Witte, Christopher A. Klebanoff, Wansang Cho, and Yongfeng He discussed "New Breakthroughs in TCR Engineering" in a major symposium at the AACR IO Conference on Discovery and Innovation in Cancer Immunology. #AACRIO26 @KlebanoffLab

@AACR Thank you for such a wonderful opportunity to connect with fellow scientists in the field! #AACRIO2026

Thrilled to share the primary focus of my PhD thesis work, now out in @ScienceMagazine today! We developed Trikines — engineered cytokines that reconfigure receptor complex assembly to reshape signaling directly in endogenous immune cells. doi.org/10.1126/scienc…

Targeting immune cells with an engineered IL-10 variant rebalances inflammatory programs in microglia, improves neurogenesis, and enhances cognition in old mice @ImmunityCP @Paloma_Negredo @BrunetLab @Stanford cell.com/immunity/fullt…

In vivo detection of immune responses via cytokine activity labeling @CellCellPress @MIT @HarvardMed cell.com/cell/fulltext/…

Can we design mutations that predictably bias proteins towards desired conformational states? Today in @ScienceMagazine, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations. science.org/doi/10.1126/sc…

What method should you use to track migrating cells? Read "Methods to analyze cell migration data: fundamentals and practical guidelines" to find the best cell tracking tool. Download the paper here: nature.com/articles/s4159…

Online now @ Cell is the yeast multicellular engineering paper from @DrFankangMeng - the fruits of his productive PhD. He developed modular synthetic biology tools to bring multicellular behaviours to yeast - adhesion, juxtacrine signalling and more. cell.com/cell/fulltext/…

Ever wondered about IL-12 toxicity? Here we build off Garcia labs and @synthekine to de-couple immune parameters and toxicity associated with IL-12 agonism: Cell Reports cell.com/cell-reports/f…

It is great honor for me to work with such a wonderful team! Thank you all for all the supports and amazing teamwork!

Excited to share the first preprint from Daniels Lab! We can generate a “landscape” of immune cell phenotype, with synthetic cytokine receptors having different combinations of signaling motifs! Find out exciting CAR T cell engineering work at: biorxiv.org/content/10.110…

This work was led by @ScienceWansang (who will be on the faculty job market in coming years), Jenny Liu (starting grad school at UCSF this fall), and @AlexBeckettPhD (who is now at Kite).

🚨 New Preprint 🚨 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? doi.org/10.1101/2025.0…