Miriam Merad, MD, PhD

Very grateful to @FGinhoux, @MartinGuilliams, @MatthewD_Park, @samhegde2006, and @naderyatim for the insightful discussions and input that helped shape this commentary. (4/4)

I also discuss how RTMs decline with age increases susceptibility to severe infections, and organ dysfunction with age & argue that RTMs are untapped therapeutic targets and that harnessing TM could transform disease prevention, tissue regeneration, and healthy aging. (3/4)

Very pleased to share this new commentary on the extraordinary biology of resident tissue macrophages (RTMs). RTMs are the most evolutionarily conserved immune cells. They emerged before adaptive immunity and blood circualtion (1/4) rdcu.be/fusPs

@IdoAmitLab @ScienceMagazine @jboumelha @SinaiImmunol Thank you 🙏

@MiriamMerad @ScienceMagazine @jboumelha @SinaiImmunol Congratulations Miriam and co. Beautiful DC science 🚀

Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) science.org/doi/10.1126/sc…

@MartinGuilliams @jonykipnis @ScienceMagazine @jboumelha @SinaiImmunol thank you Martin

@MiriamMerad @jonykipnis @ScienceMagazine @jboumelha @SinaiImmunol Congratulations to the whole Merad lab!!!! Superb work! 👏🏻👏🏻👏🏻👏🏻👏🏻

This aligns remarkably well with our work showing that age-associated RTM decline drives organ dysfunction, as discussed in our recent review (DOI: 10.1038/s43587-025-00898-y). We have now started to translate these concepts toward clinical translation. science.org/doi/10.1126/sc…

Beautiful study showing that aging leads to resident tissue macrophages (RTM) decline in number and function. EP2 deletion restores RTM phagocytic capacity and clearance of senescent neutrophils, reduces chronic inflammation, and improves cognition, muscle & cardiac function 1/2

Many thanks to our colleagues for their intellectual insights, collaboration and generosity @NikJoshi @KamphorstAlice @BcellBruno @HeleneSalmon - It was a pleasure working with you all.

Important read and highly relevant to both academia and industry

Our goal is to prevent cancer using safe immunomodulatory therapies, perhaps even a pill, in people at risk. If we succeed, preventing cancer could become one of the greatest public health achievements of our generation.youtu.be/bVCE-7UUFGE?si…

A great discussion with the fantastic @DrTomMarron @SinaiImmunol @TischCancer, beautifully filmed by @noabaker, on our work to decode how inflammation drives cancer initiation and how we can prevent cancer before it starts (1/2)

@gabyrabi @FundacionFero @CaixaResearch @FundlaCaixa congratulations my dear Gabby & so very well deserved

Inmensa felicidad y honor de recibir el Fero-Dr Baselga grant de la @FundacionFero para nuestro proyecto que propone nuevas posibles terapias en cancer de páncreas con nuestro maravilloso equipo del @CaixaResearch @FundlaCaixa Mil gracias a mis labs en Barcelona y Buenos Aires

A major step toward transplantable human organs and a reminder that macrophages are the guardians of biological identity. Beautiful ! sciencedirect.com/science/articl…

Remarkable study from Irv Weissman and colleagues @StanfordMed showing that macrophage-mediated xenophagocytosis is a key barrier to interspecies chimerism and that blocking it enhances donor engraftment. (1/2)

in this Phase 1b trial: they show that a defined 15-bacterial strain manufactured in house @IcahnMountSinai achieved similar safety, durable engraftment, and efficacy than FMT in recurrent C. difficile infection. An important step toward standardized, scalable microbial medicines

Congratulations to @jeremiahfaith1, @grinsa01, and @sinaiimmunology on a big milestone in microbiome therapeutics: nature.com/articles/s4159… (1/2)

Extraordinary advances #ASCO2026 in deadliest cancers show that cancer cures are increasingly within reach. Biggest limitation now is not science, but funding. We need a stronger NIH to remain at the forefront of discovery and keep fighting for US lives. #doubleNIHBUDGET