Hee-Woong Lim

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

Happy to share the final version of our paper describing that the widely used Ucp1-CreEvdr transgene unfortunately elicits complex developmental and metabolic phenotypes. This work was mainly driven by @ManasiHalurkar (now a PhD student at Purdue). nature.com/articles/s4146…

My bluesky account

Hi everyone!!! We are excited to re-introduce ourselves as the PhD Program in Development, Stem Cells, & Regenerative Medicine (DSRM) at Cincinnati Children’s! (formerly Molecular and Developmental Biology). Stay tuned for more info on applying to our program🎉🧬!!

We're honored to once again been named to @usnews Best Children’s Hospitals Honor Roll for the 2024-25 rankings. We ranked No. 1 in three specialties, and we placed in the top 10 for all 10 ranked specialties - cincinnatichildrens.org/news/release/2…

First peer-reviewed paper during my PhD journey: science.org/doi/full/10.11… Welcoming comments and feedbacks

📣 Review of DL techniques for multimodal spatial transcriptomics analysis. Work by @pankajrajdeo01 from @CincyInformatix. doi.org/10.1016/bs.acr… Collaborative work under the mentorship of @brucearonow, @CincyResearch. H/T and thanks to Dr. @heewlim🙏 #AI #transcriptomics

Another beautiful method paper from the Koo lab: rdcu.be/dKtlO

Our Human Bone Marrow CITE-Seq Portal (altanalyze.org/MarrowAtlas/) now hosts video and step-by-step walk through tutorials for: 1) Supervised scRNA-Seq annotation (Azimuth) 2) Comparative visualization of RNA & ADTs (ShinyCell). Please see the on-page and Synapse download links.

Many thanks to @MucosalImmunol for this honor! Enjoyed working with @baileydidriksen and @emeshlem on this review discussing how #epithelial sensing of the #microbiota can direct immune responses #mucosalimmunology #everycellisanimmunecell

@Mia__Sung @CellReports @ShahRahman054 Congratulations!

My best article @ScienceMagazine. It took ~1 year for me to publish it since its 1st submission. I hope it will positively change the #culture. I hope you will work together with me to make a better world for the next #generations. Please retweet broadly. science.org/content/articl…

Thrilled to unveil our latest endeavor: crafting vascularized lung, intestine, and colon organoids with organotypic endothelial and mesenchymal cells via a mesoderm-endoderm co-differentiation approach. Huge thanks to our collaborators @CuSTOMOrganoids @Kottond @YaWenChenMSSM

Can mutant splicing factors programs exist in the absence of mutations? In our new preprint bit.ly/3SBqZSX with @LeeGrimesLab @dstarczynowski @Amitvermamds, we show these programs exist broadly in AML, impact LSC survival and can be reversed. #OncoSplice #PRMT5 #IRAK4

Pleased to share our new study @ImmunityCP led by Dr. Emily Eshleman @emeshlem on tuft cell regulation in the intestine. Many thanks to our wonderful collaborators on this project! cell.com/immunity/fullt…

Cincinnati Children's is a cradle of discovery! Our new Research Annual Report showcases a year of innovation fueled by record-high funding. From FLASH #ProtonTherapy to driver safety training for teens with #ADHD, we're improving outcomes together: scienceblog.cincinnatichildrens.org/explore-our-20… #RAR23

(1) We are excited to finally share “Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy” at Science Translational Medicine (bit.ly/4b23Gdq). SNAF is an end-to-end workflow for splicing neoantigen & transmembrane epitope prediction...

Online Now: Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate dlvr.it/T1CDSD

CCHMC Science Blog scienceblog.cincinnatichildrens.org/how-pioneers-b…

Very happy to see this four-year collaborative work with Iwafuchi lab is finally published in @MolecularCell "Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate" @CincyChildrens sciencedirect.com/science/articl…