Jörgen Kornfeld retweetet
The songbird basal ganglia connectome biorxiv.org/content/10.110… #biorxiv_neursci
English
Jörgen Kornfeld
366 posts
Jörgen Kornfeld
@jmrko
Neuroscience, Connectomics & Connectome decoding, Machine learning, Research Group Leader @MRC_LMB @MPIforBI, co-founder of https://t.co/v1BY6BYxIs
Beigetreten Ocak 2010
335 Folgt781 Follower
PRISM has the potential to solve the proofreading challenge of connectomics for good - fantastic collaboration with E11, MIT, and the Crick!
Andrew Payne@Andrew_C_Payne
@E11BIO is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features. This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling. Using molecular annotation, we uncover an intriguing feature of synaptic organization, demonstrating how PRISM can be used for systematic discovery 🧵
English
💀 Spent hours doing email archaeology? Same.
So I built NeuralMail 📨:
🔓 Open-source
🔑 IMAP (works w/ Gmail, Outlook, etc.)
🤖 Bring your own LLM
⚡ Digs thru 100k+ emails + attachments
github.com/jmrk84/neuralm…
#NoMoreEmailArchaeology
English
Jörgen Kornfeld retweetet
Brain tissue artificially expanded to show how neurons wire together @Nature @JGDanzl @RTMojtaba
nature.com/articles/s4158…
@NatureNV @jmrko
nature.com/articles/d4158…
English
Jörgen Kornfeld retweetet
🚀 Calling all visionary scientists and engineers! Announcing our call for Focused Research Organization proposals in the UK. 🔬Submit your concept paper by Feb 7 & full proposal by March 28. ⤵️
English
Jörgen Kornfeld retweetet
E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 🧵
English
Jörgen Kornfeld retweetet
The $3B Human Genome Project was started under a Republican administration and later acknowledged by the Obama admin to have returned $141 to the economy for every $1 spent. Science has a higher ROI than any other category of government spending.
English
Interested in working on a state-of-the-art connectomics pipeline at its birthplace as a postdoc? We’d love to hear from you! :)
mrc.tal.net/vx/mobile-0/ap…
English
Jörgen Kornfeld retweetet
🧠 In #connectomics, artificial neural networks analyze biological ones, but large-scale benchmarks have been lacking. We introduce NISB - the Neuron Instance Segmentation Benchmark, generated with novel 3D diffusion models!
1/2
GIF
English
Jörgen Kornfeld retweetet
Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to @sdorkenw and Philipp Schlegel, first authors of the connectome papers, @MurthyLab @SebastianSeung for establishing #flywire to make this possible and @dddavi for birthing this dataset.
FlyWire@FlyWireNews
Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today
English
Jörgen Kornfeld retweetet
Incredibly proud and grateful to be part of the #FlyWire team that made this happen. This was an immensely collaborative project - on every level from early open data sharing, to tool building, to analysis - over many years, across many institutions. It's been a fantastic journey
FlyWire@FlyWireNews
Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today
English
Jörgen Kornfeld retweetet
🚨🎓 New application round: Join us in researching the multiple facets of biological intelligence and become a PhD student at our fully funded graduate school IMPRS-BI in the Munich area!
🔔 Application period: October 1 to November 10
🌐 Apply here: imprs-bi.mpg.de
English
Jörgen Kornfeld retweetet
Calling all emerging scientists - it’s time to send us an application! 😉😎 Lead your own #MaxPlanck Research Group w/ €2.7M in funding over 6 yrs, full independence & resources to hire staff. State-of-the-art infrastructure awaits you!🌟 Apply today➡️mpg.de/career/max-pla…
English
Fascinated by the idea of decoding memories from connectomes? Interested in working on a cutting-edge connectomics pipeline? Excited about high-throughput data acquisition or machine learning? We're hiring postdocs, PhD students, and technicians! Reach out :)
English
@AdamMarblestone @CJHandmer This looks indeed like a problem the connectomics folks have solved.... @CJHandmer feel free to reach out!
English
@CJHandmer @jmrko can the connectomics people help the ancient scroll people
frontiersin.org/articles/10.33…
English
Is there cots software that lets me load in 3D tiffs, mark them up (scribble with highlighter) in the volume, and export the scribble as a separate 3D file? Or layer by layer overlay?
I want a tool I can use to quickly and durably mark visual crackle. My current approach is using whiteboard marker on clear plastic over my screen, which lacks the ability to scroll.
Casey Handmer@CJHandmer
I'm not skilled like @LukeFarritor, also my @system76 Linux box is far too cracked to allow such luxuries as video, so instead I'll live tweet some @scrollprize reading. Let that dopamine flow as we munch on corn chips and indulge in "persistent direct visual inspection" advanced AI reading.
English
Jörgen Kornfeld retweetet
Our collaboration with @GoogleDeepMind has borne fruit! Or rather, a fruit fly 🪰🙂
Simulated with #MuJoCo physics, trained with imitation learning, capable of realistic locomotion, both on the ground and in the air. 1/n
biorxiv.org/content/10.110…
github.com/TuragaLab/flyb…
HHMI | Janelia@HHMIJanelia
🦟 By infusing a virtual fruit fly with artificial intelligence, @HHMIJanelia and @GoogleDeepMind scientists have created a computerized insect that can walk and fly just like the real thing. 🤖 🔗janelia.org/news/artificia…
English