Adam Marblestone

Beautiful work, amazing. @mattlark ovid.com/10.1126/scienc…

There is likely no open source project better positioned than Mathlib to benefit from reasoning models. Most bullish I've ever felt about an open source project. (... also, while I'm here, maybe we can make the full build times just a little bit faster? 😇 )

Researchers have long searched for the neural circuit underlying locomotion. Now they’ve found it in flies. By @natmesanash thetransmitter.org/systems-neuros…

Kudos to @NSF and the TIP Directorate for pursuing new funding models to support breakthrough team science. Big step. It's hard to imagine NSF doing this even five years ago, before: a) the important groundwork laid by CHIPS and Science to create a new directorate with a mandate to pursue new funding models; b) the philanthropic community de-risking core aspects of the FRO model; c) a new crop of science policy entrepreneurs helping to make the case; and d) the work of visionary leaders at NSF, our most important federal institution dedicated to pushing the scientific frontier

NEWS: Researchers identify first suite of human antibodies against measles virus. Read the full story ➡️ bit.ly/4tDwtx4

How it started // How it's going

Today @NSF announced a major investment of $1.5B towards a new model for scientific research🚨 NSF X-Labs will fund independent teams of researchers, engineers, and entrepreneurs to pursue bold milestone-based scientific challenges. This is how we revitalize America's scientific engine for the 21st century outside of traditional institutions, conducting science in a way that actually reflects the modern R&D ecosystem ⬇️ nsf.gov/news/nsf-annou…

NSF announces $1.5B NSF X-Labs initiative to pursue generational breakthrough science efforts. NSF X-Labs will scale a new generation of transformative independent research organizations to advance breakthrough science outside of traditional institutions. nsf.gov/news/nsf-annou…

This is super exciting

I agree, but also, I'd be a lot more bullish if we had great tools to validate and debug specifications. Good thing there's an FRO (fundraising right now...) that wants to build those as OSS public goods. (DMs open)

this is one of the most impressive things ive ever seen in a microscope

Very cool paper!

New paper from the lab. Using longitudinal ca imaging, activity-dependent tagging and optogenetics, we show that newly allocated fear engram neurons in amygdala undergo a brief period of coordinated “offline reverberation” immediately after learning. pnas.org/doi/10.1073/pn…

Where, exactly, does learning happen in the brain? Out now @Nature , we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster, but at a cost.🧵 #neuroscience nature.com/articles/s4158… Open link: rdcu.be/fiyrS

getting through the danger zone for ice formation in under a minute, with a device that only draws a few kW (work done on a pig kidney, same scale as a human kidney)

RFP closes May 11 @ 11:59pm PT, please do apply! For inspiration, here are 10 concrete projects I'd be excited to see people work on defensesindepth.bio/10-big-project…

@SynBio1 @shae_mcl @grok OpenBind for protein-small molecule data. Large data dump earlier this week End goal is to 25x all P-L available to humanity OpenBind.uk

@SynBio1 @shae_mcl @grok @EvEBiotech

@shae_mcl @grok What are some examples of public and private funding efforts intended to generate biology datasets that will enable AI applications analogous to the way the PDB enabled AlphaFold?

It’s estimated that the Protein Data Bank (PDB) cost around $13B to create. Alphafold was only possible because of it. If we want ML to solve biology, we should be funding the creation of databases and the development of new assay technologies. ML is nothing without data.

@SynBio1 @shae_mcl @grok Fwiw, at OpenADMET we are trying to do what CASP/PDB did, but for small molecule ADMET properties. Third competition on PXR activation and protein-ligand structure prediction running now. Many more to come. openadmet.org

A neural circuit through which small-molecule GLP1RAs modulate reward processing, with implications for the treatment of substance-use disorder and binge eating @Nature @deppmann @GulerLab @LizzieGodschall @bugragungul @isabellesajonia @UVA nature.com/articles/s4158…