David A. Markowitz

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David A. Markowitz

David A. Markowitz

@DavidAMarkowitz

Scientist and engineer. I develop, scale, and apply biotechnologies to benefit society.

Boston, MA Beigetreten Ekim 2011
207 Folgt2.6K Follower
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
We're at the threshold of understanding intelligence itself. The convergence of neuroscience and AI has created an unprecedented opportunity — but our research ecosystem isn't built to seize it. We need a new model that matches the scale of our ambition... 🧵
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Protocol Labs
Protocol Labs@protocollabs·
Meet the Head of PL Neuro, @SeanEscola. In his new paper, he introduces the idea of “cognitive dark matter." A thoughtful framing of one of the biggest open questions in neuroscience. 👇
Sean Escola@SeanEscola

We know about cosmological dark matter despite being unable to measure it because, without it, galaxies would fall apart. By analogy, let's talk about "cognitive dark matter" (CDM): brain functions that meaningfully shape behavior but are hard to infer from behavior alone. New paper! 🧵👇

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Tom Kalil
Tom Kalil@tkalil2050·
Pls subscribe to our new RenPhil Substack, and check out my post on "Philanthropic Moonshots and How to Launch Them." open.substack.com/pub/renaissanc…
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
Governor of Texas @GregAbbott_TX just ordered a statewide medical cybersecurity review based on my team's work for @ARPA_H. Fantastic real-world impact for patients! 👇 gov.texas.gov/uploads/files/…
David A. Markowitz@DavidAMarkowitz

🚨 There are 30M legacy medical devices in the US and 6.2 vulnerabilities per device. Our health infrastructure is NOT SECURE. To fix it, we need tools that automate vulnerability detection and remediation at scale. Today, my team is releasing those tools. 🧵

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Anastasia Gamick
Anastasia Gamick@AGamick·
Lead poisoning causes irreversible brain damage in children. Antibiotic resistance kills over a million people a year. Far-UVC could eliminate airborne pathogens in buildings. Industrial heat is 20% of global emissions. None of these problems have the company they need.
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Adam Marblestone
Adam Marblestone@AdamMarblestone·
You may have noticed some "holy $%@#" tweets on fly brain emulation. So is this a game-changer or a nothing-burger? Read on to find out...
GIF
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Doris Tsao
Doris Tsao@doristsao·
Come be my colleague! Apply to the Astera Fellows program! You will get a great salary AND very generous resources to start your own independent research program. A core area of interest is neuroscience & AI. Please RT
seemay chou@seemaychou

Also! ☝️Apps for our new residency cohort (salary AND research budgets included) are now live astera.org/residency/ -- technical innovators, check it out to see if we might be a great home for your ideas/work

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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
@BrackLab @LifeSciVC @DARPA @ARPA_H Concrete example: as an IARPA PM, I funded a buzzy VC-backed startup in a hot biotech IPO environment. The company underperformed on my program, so we cut them. If IARPA had an equity stake in the mix, I might have felt pressured to "play ball" until realizing a financial ROI.
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
@BrackLab @LifeSciVC @DARPA @ARPA_H Here's the failure mode: A typical ARPA R&D contract can be canceled for underperformance or just USG's convenience. If a performer awards equity to USG in exchange for maintenance of a contract through certain milestones, it creates a financial conflict of interest for USG.
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Bruce Booth
Bruce Booth@LifeSciVC·
Trump’s corporatism now involves the US demanding stakes in strategically important businesses that get any subsidies/grants…   Intel likely only the first of many. The big Q to me is when will they demand ownership in biopharma… like Moderna for its mRNA platform.  “We terminated your 22 BARDA grants, but we’ll reactivate them if you give us 10%…”
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
But - and I can not stress this enough - to build a BBN: You. Need. To. Know. How. To. Sell.
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
If your mission is to be the world's R&D leader in your technical area, and you are willing to work part of the time on other people's important problems, the sky's the limit on external funding availability - much of which can then be used to fund your passion projects.
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
A very well capitalized US biotech CEO told me yesterday: "Our investors are telling us to do everything in China now. Something that used to take 4 years and cost $100M in the US can now be done in 2 years for $20M by Chinese partners."
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
...which is another way of highlighting that the monetizability of neural interfaces is unlikely to scale with their throughput over the next 10+ years* *assuming a revenue model that is based on insurance reimbursements
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
My two cents: if you gave this capability to a neuroscientist, it would revolutionize how we study the non-human brain in a basic research setting. Clinically, I think this capability would far outpace our current best ideas about how to intervene in any human brain disorder.
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
What's the strongest current thesis for a problem that can only be solved by bidirectionally interfacing with *millions* of neurons in the human brain?
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
@michaelzlin Yep! MICrONS researchers at @BCM used the mesoscope to acquire the functional data that was then co-registered with neural circuit maps generated from EM. My comment was more about the ever expanding field of view by new microscopy tools.
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
Feels like we're reaching a tipping point for technologies that will unlock whole brain emulation, e.g. a team from China just announced an optical method for cellular resolution monitoring of activity across mesoscale networks than span the whole mouse brain. 👇
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David A. Markowitz
David A. Markowitz@DavidAMarkowitz·
@JacquesCarolan Yes interesting! The first author's prior published work in this area was also mostly with Chinese institutions, with 1-2 Western collaborators (not from Imperial). I'd suggest the arc of progress seems driven by Chinese institutions... nature.com/articles/s4137…
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Jacques Carolan
Jacques Carolan@JacquesCarolan·
@DavidAMarkowitz super impressive — small correction, it's china + uk (first and last author are at imperial college)
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