@EricTopol @NatureMedicine Interesting, is there any retrospective data that patients treated with digoxin for cardiac indications have a lower incidence of metastatic cancer?
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Nick Light
134 posts
Nick Light
@nick_light
Medicine, genomics, science, NBA (Raptors), running, PGY4 in Medical Oncology at @UofT_DOM, MD/PhD @UofTMDPhD (He/him)
Toronto, Ontario Beigetreten Şubat 2019
324 Folgt290 Follower
How a heart medication—digoxin—might help prevent cancer spread by dissolving clusters of circulating tumor cells
nature.com/articles/s4159…
@NatureMedicine
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Humbled to receive a #VanierCanada scholarship from @CIHR_IRSC for our work on the heart issues childhood cancer survivors endure! Vanier wouldn't have been possible w/o the people and communities I worked with in Scarborough and Princess Margaret, who inspired me to do an MD/PhD
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Nick Light retweetet
✨Check out our study✨We use germline genetic and epigenetic data to identify diagnostic biomarkers, prognostic signatures, actionable therapeutic targets and correlates of clinical heterogeneity that will allow for improved clinical management of LFS patients!
Cancer Research Communications@CRC_AACR
Just published— Multiple germline events contribute to cancer development in patients with #LiFraumenisyndrome, by @vallisubasri et al. bit.ly/3U5KG5L @UofT @sickkids #openaccess
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In the future this holistic approach could be used to develop tailored strategies for cancer surveillance in patients with this rare and devastating cancer predisposition syndrome.
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@vallisubasri used this to develop a machine learning model which can predict cancer risk in patients with Li Fraumeni Syndrome.
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Amazing work by @vallisubasri comprehensively investigating the ways in which germline genetic variants and epimutations effect cancer risk in patients with Li-Fraumeni syndrome, using whole genome sequencing and methylation data from 396 LFS patients.
Valli Subasri@vallisubasri
Multiple germline events contribute to cancer development in patients with Li-Fraumeni syndrome aacrjournals.org/cancerrescommu…
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Multiple germline events contribute to cancer development in patients with Li-Fraumeni syndrome aacrjournals.org/cancerrescommu…
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Nick Light retweetet
Happy to share our preview on the spatial organization of microbiota in cancer published in @ImmunityCP.
Original paper by:
@CJohnstonLab1 @BullmanLab @fredhutch
cell.com/immunity/fullt…
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Our study is out today in @NatureComms ! We analyzed cancer genomes from patients with Li-Fraumeni syndrome and found early copy number gain of the mutant allele of TP53 to be a characteristic feature of these tumours. nature.com/articles/s4146…
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@nick_light @NatureComms Congratulations Nick! Great work!
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Congratulations @nick_light @uoftmdphd 👏🏻👏🏻👏🏻and colleagues on this important work
Nick Light@nick_light
Our study is out today in @NatureComms ! We analyzed cancer genomes from patients with Li-Fraumeni syndrome and found early copy number gain of the mutant allele of TP53 to be a characteristic feature of these tumours. nature.com/articles/s4146…
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@vallisubasri @NatureComms Thank you Valli! So glad we got to work together on some awesome projects!
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So happy to see our study led by @nick_light out in @NatureComms today!! Fun fact: Nick was the first person I met in the Malkin lab and was an incredible mentor throughout my PhD!
Nick Light@nick_light
Our study is out today in @NatureComms ! We analyzed cancer genomes from patients with Li-Fraumeni syndrome and found early copy number gain of the mutant allele of TP53 to be a characteristic feature of these tumours. nature.com/articles/s4146…
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Amazing to watch this study grow over the past 7+ years. Congrats to the entire KiCS program!
Nature Cancer@NatureCancer
💫ONLINE NOW @NatureCancer – „The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations” by #DavidMalkin #AdamShlien & Co. 👇 nature.com/articles/s4301… nature.com/articles/s4301…
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Nick Light retweetet
Who else thinks that instead of wasting millions of tax dollars on private, for-profit agencies to provide hospitals with temporary nurses...the Ontario government should just provide ALL nurses with proper wages, permanent jobs & benefits? ✋🏾
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