Patrick Short

@MendelRoth Really interesting, thank you for flagging! Adding to my reading list for this week...!

@patrick_j_short check out this publication on AAV-related hepatic toxicity. Its a theme youve covered a good deal in your awesome podcast. New paper identifies some worrying findings. nature.com/articles/s4159…

We’re looking forward to Wednesday’s live recording of The Genetics Podcast during #JPMWeek in San Francisco. The discussion will explore lessons learned as new RNA and gene editing approaches move closer to the clinic and what it takes to translate emerging genetic modalities into meaningful patient benefit. The live podcast with @patrick_j_short, co-founder and CEO of @SanoGenetics and hosted in partnership with @FlagshipPioneer will feature Alltrna CEO Michelle Werner and @TesseraTx CEO Michael Severino Space is limited, RSVP here: events.flagshippioneering.com/livethegenetic… #tRNA #StopCodonDisease #rarediseases #JPM26 #TheGeneticsPodcast

Had a fun conversation with @patrick_j_short on The Genetics Podcast about how cardiovascular genomics has evolved, our work in heart failure, and the program we’re building @ClevelandClinic to bring genomics into real-world care. 🎧 Listen here: pod.fo/e/369253

This went live today, on Thanksgiving, which feels quietly special. This article is about one of my favorite topics: how human genetics is being used to shape drug development. It’s a synthesis of ideas and lessons that have emerged over many years, brought together into a single narrative. I’m grateful for the opportunity to give structure to these thoughts — and excited about where human genetics–driven drug development is headed next. The future here feels genuinely promising. Many thanks to the editors at @WorksInProgMag — @bswud and @salonium — for the opportunity and for helping edit this article into its best possible version. Hope you enjoy this light read on Thanksgiving Day :) 🧬 Nature’s laboratory worksinprogress.co/issue/natures-…

@MendelRoth @HeidiRehm @SlavePetrovski Yes!

@patrick_j_short @HeidiRehm @SlavePetrovski I assume it will be recorded as well?

Join me, @HeidiRehm, @SlavePetrovski TOMORROW (Oct 15th, 12-1pm) at #ASHG25 for The Genetics Podcast live. Where? Room 151A in the convention centre. See you there!!

@devpandeyay This is great stuff, looking forward to seeing the presentation!!

Half of people with heart disease first find out after a heart attack. What if we could see risk years earlier using MRI, genetics, and blood tests? We introduce preCog, a multimodal AI for preventive cardiology trained on >500k images and genetic data from 1.25M individuals.

@vagheesh Awesome work!! Looking forward to seeing the presentation.

Like 10day weather forecasting 10yr disease forecasting is a grand challenge in health. New work from our group combining virtually all data collectible from a person for state of the art prediction for coronary artery disease - the leading cause of death x.com/devpandeyay/st…

This year it is... The Genetics Podcast Live🎙️Featuring @HeidiRehm and @SlavePetrovski! 🗓️ October 15, 12:00–1:00 PM 📍 Room 151A 🥗 Lunch will be provided ⚡ Seats are limited and available on a first come, first served basis Drop me a note if you will be in town and join us!

Despite what you may have heard, the main event at American Society of Human Genetics is not your-favorite-sequencing-partner shelling out for a Maroon 5 concert...

🎙️Tune in to Episode 201 of #TheGeneticsPodcast 🚀 This week, we’re joined by Richard Wilson, Senior Vice President, Primary Focus Lead of Genetic Regulation at Astellas. Listen in to hear about where gene therapy stands in 2025, from scientific wins to persistent barriers. Patrick and Richard dive into regulatory expectations, manufacturing strategy, vector design, and how to build gene therapies that truly reach patients. A must-listen for anyone navigating the future of genomic medicine. Available here👇 🎧 pod.fo/e/319494 📽️ youtu.be/d-SYCeqMWDk #TheGeneticsPodcast #Genetics #SanoGenetics #Genomics #PrecisionMedicine #GeneTherapy #Biotech

🎙️Tune into Episode 186 of #TheGeneticsPodcast 🚀 This week we’re joined by @GilesYeo, geneticist and author. He and @patrick_j_short discuss the genetic and neural bases for obesity, the recent explosion in effective and safe obesity drugs, and nuanced perspectives on calorie counting and ultra-processed foods. Tune in here👇 🎧 pod.fo/e/2d27ba 📽️ youtube.com/watch?v=pnn5wO… #genetics #precisionmedicine #obesity

For #raredisease patients and their families, every day matters. The same is true at Alltrna, where every experiment matters, and every experiment helps us take one step forward towards our goal of transforming medicine and boldly building a new future for patients. In this interview with @patrick_j_short for 𝗧𝗵𝗲 𝗚𝗲𝗻𝗲𝘁𝗶𝗰𝘀 𝗣𝗼𝗱𝗰𝗮𝘀𝘁, Alltrna CEO Michelle Werner talks about the sense of urgency that drives her work. She also shares encouraging preclinical data in #StopCodonDisease mouse models of two #rarediseases – methylmalonic acidemia and phenylketonuria. 🎙️Listen to the full interview from @sanogenetics here: podcasts.apple.com/us/podcast/the… youtube.com/watch?v=gzSIFK… #RareAware #RareDiseaseWeek #RareDiseaseDay #RareDiseaseDay2025 #PKUAwareness #methylmalonicacidemia

@meribeckwith Congratulations!!

Very excited to announce our $55m Series B! 🍊 Everyone agrees that clinical trials today are deeply broken. But the upside to fixing this remains under-discussed... techcrunch.com/2025/01/22/lin…

Do not invest in this man who: 1. Gene edited babies without informed consent from the mothers 2. Does not know how to post in a thread

🎙️Episode 169 of #TheGeneticsPodcast is live! 🚀 This week we’re joined by @hilsomartin, Group Leader @sangerinstitute. She and Patrick discuss the role of common genetic variants in rare neurodevelopmental conditions. Tune in here👇 🎧 pod.fo/e/29b94b 📽️ youtube.com/watch?v=3rby7D… #genetics #SanoGenetics #neurology

A thread on some of the fascinating noncoding genetic discoveries from 2024. I've written long form posts and discussed on The Genetics Podcast about these stories. I'll share links to all below with a brief summary.

Episode 168 of #TheGeneticsPodcast is live! 🚀 In the first episode of 2025 we’re joined by Erik Ingelsson, Chief Scientific Officer @WaveLifeSci, who walks us through the company’s world-first discovery in #RNA therapies. Tune in here👇 🎧pod.fo/e/298920 📽️youtu.be/pdG0IDgvDFE #genetics #SanoGenetics #PrecisionMedicine

🎄 The final episode of The Genetics Podcast for 2024 is here! 🚀 Join us for a festive deep dive as @doctorveera unpacks four groundbreaking papers from this year. Don’t miss these insights into #genetics and #precisionmedicine! 🎧 pod.fo/e/2961a4 📽️ youtu.be/qRBpknTPHlU #TheGeneticsPodcast #SanoGenetics

The Genetics Podcast is one of the best to listen to in the human genetics and drug development space (not because I was in it ;))