Patrik Andersson

CAR-T cell therapy can be great, but.. the T cells express PD1 and get exhausted. Check out this #GIF I made for a recent @jitcancer paper on this topic (bit.ly/35G8na3) ___ #cancer #immunotherapy #AcademicChatter #AcademicTwitter #scicomm (credit: @Biorender)

Just like people, T cells get exhausted. Taking a break helps! Here, the authors developed a SNIP CAR - “a protease-based platform for regulating CAR activity using an FDA-approved small molecule”, which showed diminished T cell exhaustion bit.ly/3LgUqUr #Immunotherapy

How can regulatory T cells (Tregs) be depleted in cancer? In this recent paper in @ScienceTM, the authors show how dual targeting of CTLA4 and CD47 on Tregs is effective. bit.ly/3yT5DWd #AcademicTwitter #Immunotherapy @UTSWNews

What’s happening with CAR-T cells and beyond in cancer? This nice review summarizes recent advances and efforts to leverage T cells and NK cells. nature.com/articles/s4142… #Immunotherapy #AcademicTwitter

Can pre-treatment with targeted therapy influence response to subsequent immunotherapy? Here, they show that "when tumors relapse after anti-MAPK targeted therapy, they are cross-resistant to immunotherapies". nature.com/articles/s4301… #Immunotherapy @NatureCancer

Can immunotherapy provide long-term responses? Median survival (months) for metastatic melanoma was reported at ASCO for: CTLA4 + PD1 👉 72.1 PD1 👉 36.9 CTLA4 👉 19.9 #AcademicTwitter #cancer #Immunotherapy @ASCOPost ascopost.com/news/june-2021…

Predicting response to immunotherapy is important, but what’s a good marker? Here they show how TCR clonality of tumor-infiltrating T cells predict anti-PD1 efficacy: nature.com/articles/s4146… #AcademicTwitter #cancer #immunotherapy @NatureComms

Does tumor location/tissue site matter? Here they show how the same tumor cell line display different take rates, immune infiltration, and response to immunotherapy depending on where the tumor grows. cancerimmunolres.aacrjournals.org/content/early/… #AcademicTwitter #cancer #Immunotherapy @CIR_AACR

How do tumor cells survive in the circulation? This recent paper highlights the importance of CCL5 as a mediator of immune evasion. nature.com/articles/s4146… #AcademicTwitter #cancer @NatureComms

@Tcellogic @patrickreville Such clever and beautiful illustration👏🏻

My 14 yr daughter just made this beautiful illustration for our study on CD36 in CD8 T cells. authors.elsevier.com/a/1dCK33qNrUmR… If you need any artwork for your papers or slides, let me know. She would love to do more!

@patrickreville @NatImmunol @ljiresearch I agree! The conclusion is more based on the clinical data, which is intriguing

@pcandersson @NatImmunol @ljiresearch seems this experiment is missing some controls

When to give immunotherapy? Giving anti-CTLA4 BEFORE anti-PD1 was found to be superior in this recent paper: go.nature.com/3w43rZL #AcademicTwitter #Immunotherapy @NatImmunol @ljiresearch

#cancer #Immunotherapy

Who will respond to immunotherapy? This recent paper suggests that the tumor microenvironment falls into 4 categories and can predict therapeutic response: bit.ly/3wQDcXR #AcademicTwitter @MDAndersonNews @BostonGeneCorp

Cool new finding and beautiful images when researchers identify "a link between sensory neurons activation and the immune system". #AcademicTwitter #phdchat medicalxpress.com/news/2020-09-l…

Send a picture of something that shows very clearly you are a Grad/Undergrad student! This is mine 🤣 #phdchat @AcademicChatter @OpenAcademics @PhDVoice

Repurposing of drugs for cancer is already a popular strategy. Should all drugs, within reason, that have passed toxicity studies in any indication, be tested in preclinical models of cancer in a high-throughput manner? #AcademicTwitter

Just me having too much fun editing this video! Tell me more about you #phdchat #phdlife #postdoc #academictwitter

Let me know if you have entered this graphical abstract contest at @BioRender - I would love to share yours❤️ #AcademicTwitter #phdchat #scicomm biorender.com/graphical-abst…

It really hits me hard seeing young people die in cancer. Moments of feeling hopeless is exchanged with motivation. Motivation to do better, to contribute to better therapies. What's your motivation? #AcademicTwitter #cancer #phdchat #beatcancer

Making friends with scorpions? 🦂 Enter this competition at @BioRender or just vote for my contribution 😃 #AcademicTwitter #sciencetwitter #phdchat #scicomm #cancer #Immunity #scicomm Link: app.biorender.com/contest/galler…