Tej Pratap Singh
109 posts
Tej Pratap Singh
@tpsinglab
Cellular immunologist exploring the complex interactions of immune cells and microbiota in skin.
University of Pennsylvania Beigetreten Ekim 2021
178 Folgt53 Follower
TIME's list of the 100 Most Influential People in the world is out. I'm honored, delighted, and grateful to be a part of this incredible group #TIME100 🙏🏼🙏🏼🙏🏼 @TIME
time.com/6964230/akiko-…
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Tej Pratap Singh retweetet
"..cause it's not about the money"
Dr. Glaucomflecken@DGlaucomflecken
I’m seeing some “free market” simps defending Nature’s 12k open access fees. Guess it’s time to bring this back around.
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Honored to be elected to the American Association of immunologists (AAI) council and looking forward to working with my colleagues in the years to come!
The American Association of Immunologists (AAI)@ImmunologyAAI
AAI is proud to announce our newly elected council & committee members! Their terms begin July 1, 2024. Thank you to everyone who voted! Your participation in the process contributed to the advancement of AAI's future. #gsc.tab=0" target="_blank" rel="nofollow noopener">aai.org/About/Leadersh…
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CXCL12+ dermal immune acting fibroblast communicate with neutrophils via IL17RA during type 17 inflammation @JExpMed @KellenCavagnero
doi.org/10.1084/jem.20…
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Tej Pratap Singh retweetet
Barriers sites are characterized by complex immunological crosstalk between pathogens, commensals, and the immune system. Explore this collection highlighting recent JEM papers dissecting barrier immunity at the epithelial and neurovascular barriers. ➡️ hubs.la/Q02kSy9_0
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Tej Pratap Singh retweetet
.@tpsinglab et al. reveal that Treg levels function as a rheostat, controlling bacteria in the skin & influencing whether bacteria induce IL-17 or IFN-γ-mediated immunopathology hubs.la/Q02kSFC90
In our Barrier Immunity collection: hubs.la/Q02kSy4j0
#KSBarrierReg24
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Tej Pratap Singh retweetet
How do systemic PAMPs become accessible to cytosolic PRRs in vivo? Thrilled to have our work out @NatureCellBio showing Host EVs capture and escort systemic LPS to cytosol activating Casp11 & pyroptosis. Congrats to Puja @dolly_puja, who led the work. 1/3 nature.com/articles/s4155…
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Tej Pratap Singh retweetet
A great mentor, a great scientist, a great human being, the best person for this position at Pasteur. We miss you at @NIH already!
Institut Pasteur, since 1887@institutpasteur
La Professeure Yasmine Belkaid prend ses fonctions en tant que Directrice Générale de l'Institut Pasteur ↘️pasteur.fr/fr/espace-pres…
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Intestinal inflammation is driven by unrestrained activation of IFNγ-producing CD4+ T cells and depletion of peripherally induced regulatory T cells through Fcγ receptor signaling.
Ivan Zanoni@Lo_Zanzi
#MicrobiotaPower! Anti-tumor checkpoint blockade therapy can lead to #colitis, Nunez &co show @ScienceMagazine that this happens in mice that harbor microbiota of wildlings. Colitis is driven by FcgR that depletes Tregs & boosts IFNg production by T cells! science.org/doi/10.1126/sc…
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Tej Pratap Singh retweetet
Fantastic @Nature by Nir Hacohen &co! They created gene transcription maps at the single cell level for 17 different cell types in the lymph node in response to each of the 86 cytokines & develop a tool to infer from RNAseq data cytokine activity! nature.com/articles/s4158…
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Tej Pratap Singh retweetet
We highlight how the human microbiome can shape disease outcomes in cutaneous leishmaniasis and suggest pathways toward host-directed therapies to mitigate the inflammatory consequences. Nice work @amorim_cfa @microbiome @RNAseq @immunology
science.org/doi/10.1126/sc…
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We appreciate immensely the @LionakisLab, for your insights on our recent work showing that Foxp3+ Rorγt+ Tregs suppress pathogenic IFN-γ responses to control S. aureus growth @tpsinglab @pscottlab #eGrice
Journal of Experimental Medicine@JExpMed
Insights from @LionakisLab: Mibrobial dysbiosis worsens cutaneous leishmaniasis. @tpsinglab, @pscottlab et al (bit.ly/3MgOlen) show that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth bit.ly/48Y7iMy
Philadelphia, PA 🇺🇸 English
Insights from @LionakisLab: Mibrobial dysbiosis worsens cutaneous leishmaniasis. @tpsinglab, @pscottlab et al (bit.ly/3MgOlen) show that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth bit.ly/48Y7iMy
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Tej Pratap Singh retweetet
Using Foxp3+ Treg cell counts, we categorized patients in a skin #RNAseq dataset. In Leishmania+S.aureus co-infection cases, low Foxp3+ Treg levels connect to harmful IFN-g #inflammation and slower healing, unveiling its dual role in infections. #NGS #datawrangling #translational
Journal of Experimental Medicine@JExpMed
Study by Singh, Scott et al. @PennMedicine involving mice and #Leishmania braziliensis patients reveals that Treg levels function as a rheostat, controlling bacteria in the skin & influencing whether bacteria induce IL-17 or IFN-γ-mediated immunopathology. bit.ly/3MgOlen
Philadelphia, PA 🇺🇸 English
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