HeilemannLab (👉🏻 heilemannlab.bsky.social)

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HeilemannLab (👉🏻 heilemannlab.bsky.social)

@HeilemannLab

Single-molecule biophysics lab at Goethe University Frankfurt. Super-resolution microscopy. We moved 👉🏻 https://t.co/hdHe9Trgyb

Frankfurt, Germany Joined Eylül 2021

124 Following1.1K Followers

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·31 Ağu

Two great days of science at the #SMLMS2022, culminating with a conference dinner on the boat on the Seine. So many great conversations 🙏. Happy to present our choreography to show our appreciation to this event (watch the light pattern!).

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Beck Laboratory@Beck_Laboratory·11 Ara

… and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors. rdcu.be/d3dmN

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Dr. Florencia Sánchez@MFSanchez_Lab·5 Ara

Open postdoctoral position in my group! jobs-sf.ukmuenster.de/job/UKM-Postdo… We search for a very talented student in the field of super resolution microscopy! @UK_Muenster @uni_muenster #academia #newPI

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·4 Ara

Kudos to Enya & Laurell for their fantastic work! Great collab🙏w/ Bernd Rieger & Sjoerd Stallinga (TU Delft) Michaela MüllerMcNicoll (@goetheuni) & great support by @ashwin0512. We are very excited about the results & curious to see your feedback 👉🏻 doi.org/10.1101/2024.1…

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·4 Ara

By labeling the architectural RNA NEAT1 in paraspeckles (PS) at various positions using RNA-FISH-DNA-LNA probes, we learnt 3 new things: (1) the morphological space & shape progression of PS, (2) the orientation/packing of its RNA, (3) the coarse conformation of NEAT1. (2/3)

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·4 Ara

We modified our STED🔬to make it more efficient ('smart') to acquire high-resolution data of small and rare objects in a 3D cell volume. This enabled collecting a large amount of data in a fully automated fashion. With that, we visualized the ultra-structure a nuclear body👇🏻(1/3)

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·3 Ara

bsky.app/profile/heilem… 🙏hoping to re-connect to many of you

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·26 Kas

Long-term single-protein tracking up to 30 min allowed monitoring the dynamics of EGFR activation in living cells (and more)👇🏻Great work by a fantastic team and great collaboration with @JulianKompa Kai Johnsson @mpi_mr_hd 🙏 @sfb1507 @goetheuni

Angewandte Chemie@angew_chem

Long-Term Single-Molecule Tracking in Living Cells using Weak-Affinity Protein Labeling (Mike Heilemann and co-workers) @HeilemannLab #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·12 Kas

@sjoerdjlvanwijk @CovinoLab @goetheuni @fias_science @sfb1507 Thank you, Sjoerd! 🙏

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Sjoerd van Wijk@sjoerdjlvanwijk·12 Kas

@HeilemannLab @CovinoLab @goetheuni @fias_science @sfb1507 Congratulations!

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·12 Kas

🙏happy that this article is out now: we used an integrative approach (MD, single-molecule imaging, FRET) to reveal early activation of the receptor tyrosine kinase MET in cells👇🏻A wonderful collaboration with @CovinoLab & great co-workers 🙏@goetheuni @fias_science @sfb1507

Roberto Covino@CovinoLab

Check out how we used simulations and single molecule FRET to determine how a invasion bacterial protein activates a plasma membrane receptor to enter our cells. Kudos to @serena_arghittu and @gabriel_hella, and great collaboration with @HeilemannLab nature.com/articles/s4146…

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·12 Kas

Many thanks to the reviewers for great input (yes) and to the Editor & team of @NatureComms 🙏

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·21 Eki

Gen-AI producing fancy data augmentation for Super-resolution microscopy! Great work @AlonSaguy and team! @HenriquesLab @HeilemannLab

Ricardo Henriques@HenriquesLab

If robots could dream of microtubules, how would they look like? An amazing story by Alon Saguy, @ShechtmanLab and colleagues. Proud we could contribute to it onlinelibrary.wiley.com/doi/10.1002/sm…

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Zhixing Chen@ZhixingChen2·3 Eki

Our Gentle Rhodamines is finally published @ACSCentSci. See the healthy cytoskeleton free from photodamage even after 800 frames! 🦾💪 pubs.acs.org/doi/10.1021/ac… Great collaboration with Julian Kompa, the Johnsson group, and Spirochrome! @JulianKompa @spirochrome @TianyanL

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Achillefs Kapanidis@AchillesKap·11 Tem

3 weeks to go... send us your single-molecule bacterial stories for our Cotswolds get-together!

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·17 Eyl

@glembockyte @mpi_mr_hd Congratulations, Victorija! And a great start! 🎉

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Viktorija Glembockyte@glembockyte·17 Eyl

Excited to share that this fall I will be starting a group at Max Planck Institute for Medical Research in Heidelberg @mpi_mr_hd! Join our team if you are interested in exploring the nano world one molecule at a time 🧬🔬 mr.mpg.de/14599619/singl…

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Siewert Hugelier@SHugelier·10 Eyl

Interested in a fully automatic analysis pipeline to quantify and classify your 2D and 3D Single-Molecule Localization Microscopy (SMLM) data in an unbiased way? Have a look at our latest work covering ECLiPSE, developed in the @Melike_Lak lab! doi.org/10.1038/s41592… 1/11

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·9 Eyl

@DedeckerLab @naturemethods @vandenberglab Congratulations, Peter & team, very nice work!

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Dedecker Lab (dedeckerlab.bsky.social)@DedeckerLab·9 Eyl

Very happy to share the 'Circulator' paper, which is now out in @naturemethods ! 🥳 👉rdcu.be/dTa4v Together with @vandenberglab!

Nature Methods@naturemethods

Out today from the Vandenberg and Dedecker labs! PSF splitting with the ‘Circulator’, which encodes the fluorophore emission band into the PSF, improves the information content of fluorescence microscopy and enables improved super-resolution imaging and single-particle tracking.

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HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted

Julien Hiblot@JulienHiblot·2 Eyl

Why reinvent the wheel when you can enhance it? We’ve focused on making SNAP-tag better. @SteffiKuehn developed SNAP-tag2, with an optimized substrate. Faster labeling, brighter fluorescence-this is the upgrade you've been waiting for!

Stefanie Kühn@SteffiKuehn

Preprint alert🚨Did you ever experience issues in labeling kinetics and fluorescence brightness, when working with SNAP-tag in live cells? Our newly developed SNAP-tag2 system might be the solution! 🚀Check out our latest preprint on #bioRxiv: 🔗biorxiv.org/content/10.110… (1/4)

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HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted

Single Molecule Localization Microscopy Symposium@SMLM_Symposium·31 Ağu

We see each other next year in Bonn, Germany in #SMLMS2025 hosted by @UEndesfelder and @HeilemannLab

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·31 Ağu

@Dr_Fluo @Melike_Lak ... very good memories. I am waiting for the group photo of #SMLMS2024 to put that next to it in the gallery 😅

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Virgile Adam (🦋@drfluo.bsky.social)@Dr_Fluo·31 Ağu

@HeilemannLab @Melike_Lak It was even called SwissPALM! Thanks for the young faces memories Mike 😳

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HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·31 Ağu

I am chiming in: fantastic meeting, congratulations and thank you to @HenriquesLab and @MicrobeMatos & entire team! #SMLMS2024 @SMLM_Symposium Looking forward to #SMLMS2025 and working with @UEndesfelder to make it happen. The bar is high 😅. Hope to see you all again in Bonn!

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@HuaipengXing @FrydmanLab @Nature @UK_Muenster @uni_muenster @goetheuni @ashwin0512 @JulianKompa