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Stegle Lab
62 posts
Stegle Lab
@StatGenomics
We're moving to Bluesky - come join us: https://t.co/nHQ8M13K8Z
Heidelberg, Germany Joined Eylül 2013
53 Following3.2K Followers
Our paper on using machine learning to predict the impact of rare genetic variants is out! #DeepRVAT utilizes a fully data-driven approach to analyze annotated variants.
@DKFZ press release: dkfz.de/en/presse/pres……Publication in @NatureGenet: nature.com/articles/s4158…
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We are looking for a postdoctoral researcher!
Join our translational project aimed at exploring the processes that alter the epigenetic landscape of colorectal cancer cells and drive their metastasis.
Become part of our group at @EMBL
Apply here: embl.org/jobs/position/…
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Amazing work from our #DeepRVAT team! Using AI to predict the effects of rare variants, pushing the boundaries of personalised medicine. 🧬🔍
Check out the thread and explore their exciting results yourself!
Brian Clarke@brianfclarke
🧵 1/9 Delighted to announce that #DeepRVAT is out today in Nature Genetics! Here's a recap of our tweetorial from the preprint, with updates for some exciting new results. It's been a joy to work with @Holtkamp_Eva, as well as @gagneurlab and @OliverStegle.
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Stegle Lab retweeted
Apply now for the DKFZ #Postdoc|toral Fellowships at the German #Cancer Research Center, covering all areas of #cancerresearch, including #epigenetics, #genomics, #stemcells, #radiooncology, #epidemiology. To apply for your #PostdocFellowship visit ➡️ t1p.de/4t3fp
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Do you want to pursue a PhD at the intersection of AI and the life sciences? 🤖🧬
We are recruiting through the @hidss4health program! Join an exciting project on multi-omics factorization models for personalized medicine with @JunyanLu1118.
Apply here: #apply" target="_blank" rel="nofollow noopener">hidss4health.de/#apply
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#CHOCOLAT_G2P 🍫🐭 is available as a preprint! Our collaborative project on tumor spatial genomics, showcases a new technology enabling induction and spatial genotyping/phenotyping of hundreds of tumors in mouse liver. Check out the thread for the nuts and bolts of 🍫-G2P!
Tschaharganeh Lab@tschaharganeh
0/ Preprint alert! 🚨 One step closer to solving the genotype ➡ phenotype puzzle in cancer! Led by @BreinigMarco, @LomakinAI, and @HeidariElyas, our novel approach, #CHOCOLAT_G2P 🍫, deciphers the impact of combinatorial alterations on tumor phenotypes and their environment.
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🌟 Be part of our team!
Join our lab for a postdoc in computational biology, focused on multi-omics profiling in time and space.
Apply now: embl.org/jobs/position/…
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One framework to rule them all: SpatialData 🔳
Excited to see our efforts in unifying and integrating multimodal spatial omics data highlighted by @embl. Phenomenal teamwork with @fabian_theis and @notjustmoore and more! 💪
Published in @naturemethods: nature.com/articles/s4159……
EMBL@embl
SpatialData is a tool developed by EMBL scientists in cooperation with multiple research institutions to unify & integrate data from different omics technologies. It provides holistic insights into health & disease and is publicly accessible. embl.org/news/science-t…
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Two wheels, one method to infer causality in biological networks: Bicycle! 🚲
Thrilled to share our team's breakthrough.
Dive into the details in the thread below 👇
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We are seeking a postdoctoral researcher at @EMBL!! 🦸♀️
Are you passionate about applying machine learning to unravel the causal mechanisms of gene regulation?
Apply now: embl.org/jobs/position/…
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Join our team! We are seeking a postdoctoral researcher! 🚀
Are you enthusiastic about using machine learning to decode the intricate world of cancer evolution? Join our collaborative project with @odom_lab at the @DKFZ.
Apply now: jobs.dkfz.de/en/jobs/166489…
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Two papers up in @NatGenet on the same day!
1) Population-scale single-cell RNA-seq profiling across neuron differentiation go.nature.com/3rifukq
2) Identification of regulatory variants in pluripotent cells using population-scale transcriptomics go.nature.com/3ru6o3W
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New lab paper up. Work by @BrittaVelten. We married up GPs with sparse factor analysis, which turns out to be a great fit for dealing with spatio-temporal data.
Britta Velten @brittavelten.bsky.social@BrittaVelten
Are you working with longitudinal/temporal/spatial omics data? Have a look at our new preprint: biorxiv.org/content/10.110… We present MEFISTO a method for the functional integration of spatial and temporal multi-omics data. Joint work with @OliverStegle @RArgelaguet
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Stegle Lab retweeted
New Paper up! Great multi-lab team effort with @gagneurlab @anshulkundaje to establish a repository of ML models in genomics.Give @KipoiZoo a go!Large collection of ready-to-use models to predict molecular outputs from splicing to TF binding and more! nature.com/articles/s4158…
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Stegle Lab retweeted
We are recruiting for an MRC Programme Leader at Director of Research level, in Statistical Methodology for Systems Omics #statistics #recruiting @MRC_BSU @Cambridge_Uni. Deadline for applications: 25th March
jobs.cam.ac.uk/job/20465/
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New lab paper is up. StructLMM is a method to jointly test for genotype-environment interactions using tens or hundreds of exposures. Yields new GxE signals for BMI and gene expression traits. By @rachelmoo and @fpcasale with Barroso lab at Sanger. nature.com/articles/s4158…
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New lab paper together with @sysbiomed. Great collaboration, providing new cues on the germline component of inter individual variation in drug response.
Saez-Rodriguez Group@saezlab
Menden @fpcasale et al. The germline genetic component of drug sensitivity in cancer cell lines - joint work w @StatGenomics ebi.ac.uk/about/news/ann… nature.com/articles/s4146…
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Stegle Lab retweeted
Paper on interpretable and sparse factor analysis for scRNA-seq is up. Generalises scLVM; software for R & python! genomebiology.biomedcentral.com/articles/10.11…
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