Rob Fried

@mkaeberlein @nytimes @SmithDanaG There are several studies that show a decline in tissue NAD with age . Studies show NAD decline with cell damage. See @charlesmbrenner excellent posts on why blood NAD is not the best measure @mKaeberlein indicates scientists should avoid making conclusions from one study

Nice article in @nytimes by @SmithDanaG on the recent findings that circulating NAD levels do not decline with age in humans. nytimes.com/2026/05/23/wel… These new data are important because the original model was always supported more by marketing narratives and extrapolation than by strong human evidence. For years, the claim that “NAD declines with age” has often been presented as established fact when, in reality, the data were limited and inconsistent. To be clear, NAD biology absolutely matters. Understanding how NAD metabolism changes across specific tissues, disease states, and metabolic conditions remains an important scientific question. But absent convincing evidence that NAD broadly declines across tissues and organs during normal human aging, we should be willing to conclude that the broader hypothesis has failed. That’s how science is supposed to work. The burden of proof rests on those making the claims. The case for widespread NAD precursor supplementation as a gerotherapeutic is further weakened by the fact that preclinical studies reporting benefits for lifespan and healthspan have often lacked robust reproducibility across laboratories and model systems. And in humans, there is still remarkably little evidence supporting broad NAD precursor supplementation for otherwise healthy people. At the same time, I do think there are likely subsets of individuals with significant mitochondrial or metabolic dysfunction where NAD dyshomeostasis is real and therapeutically relevant. Those individuals may ultimately benefit from targeted interventions aimed at NAD metabolism. But the evidence increasingly suggests this is probably a small subset of people — not the average healthy aging adult. Science advances by testing hypotheses against data, not by repeating narratives until they become accepted dogma.

@mkaeberlein Perhaps you and Dr Brenner can work together to investigate the relationship between tissue NAD levels and aging ?

@mkaeberlein Dr Brenner has pointed out that NAD levels do decline with age . They do not decline in blood . They decline in tissue where it matters most.

NAD probably doesn't actually decline with age. This is one of the problems in NAD-world that I've been warning about for years. I'm glad to see it finally reaching publication. nature.com/articles/s4225… The myth that NAD levels broadly change with age in humans and other animals has been propagated by some high-profile people in the field, both in the scientific literature (mostly review articles not real data, which should tell you something) and in the pop-sci podcast world. This has generated hundreds of millions of dollars in sales for NAD precursors and hundreds of millions of dollars in grant funding for those investigators. To be clear, NAD biology is real and important. There are likely specific disease states, tissues, or individuals where NAD availability becomes limiting and where interventions targeting NAD metabolism may prove useful. But that is very different from the much broader claim that declining NAD is a universal driver of normal aging in otherwise healthy people. The evidence increasingly suggests that NAD precursors like NR and NMN do not extend lifespan in mice under standard conditions and likely provide limited or no meaningful benefit to the average healthy person. This is a good reminder of how science should work. Strong claims require strong evidence, especially when they become the basis for major commercial industries and public health narratives. Aging biology is complex, and we need to be careful not to confuse plausible mechanisms with demonstrated outcomes.

What is a USP Monograph and What Does It Mean for NRCl? | AboutNAD aboutnad.com/blogs/blog/nic…

@RichCimini Can the commissioner influence an owner to sell? Would be good for football

More from Phillips: "For 15 years (the playoff drought), I get your frustrations, but for us new people to this organization, it's our first year and you have to give us some grace."

@latterddssaint @CharlesMBrenner Ask Charles he’s the expert. I know the pathways and have read the papers but he’s the expert on this.

suggestions of positive activity for Niagen NR in long COVID in improving sleep quality & executive function, & reducing fatigue & depression sciencedirect.com/science/articl… #RCT

Jets are 5th all time in AFC East titles - there are 4 teams in the division

Tru Niagen NAD+ Supplement Review thedailybeast.com/tru-niagen-nad…

6 Steps To Preserve Brain Health Now To Prevent Dementia As You Age forbes.com/sites/bryanrob…

Vogue’s Guide to the Best NAD+ Supplements | Vogue vogue.com/article/best-n…

@UCSB_Baseball congratulations to senior data analyst, Jeremy Fried. We are very proud of you.

@niagenbio Congratulations, once again, to the dedicated team at Niagen Bioscience for another record quarter!

Rob Fried, Chief Executive Officer of Niagen Bioscience, comments on the Company's recently reported first quarter 2025 financial results. Learn more: bit.ly/3GJjOFP $NAGE

2024 was a seminal year for Chromadex, for Tru Niagen and for NAD science . Congratulations and thank you , once again, to the dedicated and smart working team, partners , investors, researchers, regulators and consumers who contributed to a record year @chromadex@truniagen

@RichCimini Gruden

#Jets fan poll: Who do you want as head coach? Not saying these are the 4 finalists; just 4 intriguing names.

We can take high resolution images of galaxies predating the Big Bang yet cannot get an image of a drone flying 1000 feet above New Jersey? #drones

@unteagle2019 We offer stick packs which can be mixed with water to drink

@Aging_Scientist @mkaeberlein Tru Niagen . Chromadex. Over 30 peer reviewed clinical studies . Over 100 published pre-clinical studies. Two Nobel Prize winners.

@mkaeberlein what if we founded an evidence based supplement company? it would be niche for sure without all the lies but could become a thing....

This showed up in my email, and I just lost all respect for Thorne as a supplement brand. Peddling the most debunked "anti-aging" molecule in history as an anti-aging molecule... Is there anyone you can trust in the supplement industry?