Turvey lab

The Current with Matt Galloway - March 9, 2026: How a gene edit gave a B.C teen his life back cbc.ca/listen/live-ra…

Stuart Turvey and colleagues @BCChildrensHosp review how the early life #microbiome shapes immune programming in childhood #asthma and #allergies: mucosalimmunology.org/article/S1933-…

What can dirty diapers tell us about #asthma? Clues from the gut #microbiome are reshaping how we understand pediatric asthma and allergies! Breastfeeding, B. infantis, and early microbial exposures matter. @WashUMedPeds #Keynote by Stuart Turvey

ASXL1 deficiency causes epigenetic dysfunction, combined #immunodeficiency, and EBV-associated lymphoma, say Maggie Fu, Mehul Sharma, Michael Kobor, Stuart Turvey, Catherine Biggs et al. hubs.la/Q03zN1k20 #InbornErrorsOfImmunity

Ultimate precision medicine! Delighted to have played a small part to ensure our patient from @BCChildrensHosp was able to receive this remarkable curative treatment. Kudos to @ElieHaddad55 for launching this trial in Canada. @NEJM @UBCNews @BCCHF @GenomeBC @GenomeCanada

Ultimate precision medicine! Delighted to have played a small part to ensure our patient from @BCChildrensHosp was able to receive this remarkable curative treatment. Kudos to @ElieHaddad55 for launching this trial in Canada. @NEJM @UBCNews @BCCHF @GenomeBC @GenomeCanada

Ultimate precision medicine! Delighted to have played a small part to ensure our patient from @BCChildrensHosp was able to receive this remarkable curative treatment. Kudos to @ElieHaddad55 for launching this trial in Canada. @NEJM @UBCNews @BCCHF @GenomeBC @GenomeCanada

Ty Sperle says he felt "insane shock" after learning he'd been cured of a rare genetic disease through a clinical trial using a new gene-editing treatment. cheknews.ca/b-c-man-cured-…

Ultimate precision medicine! Delighted to have played a small part to ensure our patient from @BCChildrensHosp was able to receive this remarkable curative treatment. Kudos to @ElieHaddad55 for launching this trial in Canada. @NEJM @UBCNews @BCCHF @GenomeBC @GenomeCanada

Ultimate precision medicine! Delighted to have played a small part to ensure our patient from @BCChildrensHosp was able to receive this remarkable curative treatment. Kudos to @ElieHaddad55 for launching this trial in Canada. @NEJM @UBCNews @BCCHF @GenomeBC @GenomeCanada

Vancouver Sun vancouversun.com/health/b-c-tee… via @VancouverSun Proud to see our patient from @BCChildrensHosp get this 'first-in-the-world' curative treatment through prime editting! @ElieHaddad55 @NEJM @UBCNews

@HsiehElena Amazing!

Thanks Hal Hoffman, Lori Broderick, and Cathy Collins for the surfing lesson and invitation for UCSD grand rounds!

The @CHILDSTUDY is following nearly 3,500 children from before birth into adolescence, leading to new diagnostic tools, treatments, and preventative strategies for a range of childhood conditions. Learn more: cihr-irsc.gc.ca/e/54571.html?h…

Bravo @ElieHaddad55! This is a remarkable achievement in the field of inborn errors of imunity. @ClinImmSoc @Info4PI @ESIDsociety @NEJM

👏👏This is really a remarkable breakthrough in treating patients with chronic granulomatous disease👏👏 Proud to have played a very small part in this medical miracle. @ElieHaddad55 @Info4PI @ClinImmSoc @BCCHresearch @BCCHF @UBC @NEJM

Thanks for sharing @LabWaggoner!

📢📢NEW PAPER📢📢 Sequencing has greatly accelerated the number of human genetic immune disorders-we immunologists call them 'inborn errors of immunity'. This review in @JExpMed summarizes all the described single gene defects affecting the IRF family of transcription factors.

Stojcic, Yousefi, Biggs, and Turvey @turveylab @UBC review the biology and clinical features of inborn errors of IRFs, a group of monogenic disorders affecting the IRF family of transcription factors. hubs.la/Q03VrjjF0 #Immunodeficiency #HumanDiseaseGenetics

Outstanding study. This study establishes ThPOK as a critical regulator of human immune and fibrotic homeostasis, with the ThPOKK360N variant causing a novel syndromic disease through multimorphic effects. It challenges existing paradigms of ThPOK’s role in Th2 differentiation, highlights its unexpected function in suppressing fibrosis, and identifies pirfenidone as a promising therapeutic. While limited by its single-patient design, the rigorous mechanistic analyses provide a strong foundation for future research. Identifying additional patients, modeling the variant in vivo, and exploring ThPOK’s tissue-specific roles will further elucidate its multifaceted contributions to human health and disease, potentially transforming diagnostics and treatments for immune and fibrotic disorders.

Proud to have worked with Dr. Catherine Biggs and @koborlab to add a new human #InbornErrorOfImmunity to the list! @GenomeBC @UBC @CIHR_IRSC @CIHR_IHDCYH @BCCHresearch @_HealthyStarts