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CV Health

@CV_HealthNews

Raising awareness on cardiology health

Bergabung Aralık 2017
341 Mengikuti123 Pengikut
CV Health
CV Health@CV_HealthNews·
@SABOURETCardio Out of curiosity, will these data be enough for inclisiran's reimbursement France? Not sure if they need to wait for CV outcomes for long-term (3-4 years).
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Dr. Glaucomflecken
Dr. Glaucomflecken@DGlaucomflecken·
An American experiences universal health care
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Michael Gitter
Michael Gitter@michaelgitter·
Who came up with #LEQVIO and why don’t they have pronounceable names for drugs anymore? Here’s a name for your “inclisiran”, cholesterol drug, @Novartis. How about “Chlower” as in CHolesterol LOWER. Makes more sense than something totally unpronounceable and forgettable.
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CV Health
CV Health@CV_HealthNews·
@skathire Hi Dr. Kathiresan, thanks for sharing this data. It is indeed very interesting. Do you know how we know they are expected to reach >80% LDL-C reduction?
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Sek Kathiresan MD
Sek Kathiresan MD@skathire·
Drumroll... single infusion of a multiplex base editor in NHPs leads to ≥90% reduction in both PCSK9 and ANGPTL3 proteins in blood!! in humans, this is expected to lower LDL-C by >80%
Sek Kathiresan MD tweet media
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CV Health
CV Health@CV_HealthNews·
@youshizhiyu_ 你知道是在哪個國家的衛生部註冊為Sibrava嗎？之前的商品名稱好像是Leqvio.
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有时治愈
有时治愈@youshizhiyu_·
👨‍🔬为了治疗高血压，又加了坏胆固醇注射剂！ 卫生部已从诺华注册了降脂药物Sibrava（inclisiran）。 这是针对高危患者的一流降胆固醇药物。 💉 皮下给药溶液形式的产品是使用 mRNA 技术开发的。 Inclisiran 每年给药两次。 该药物此前已获得美国食品和药物管理局的批准。
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CV Health
CV Health@CV_HealthNews·
@RheumNow Was it approved under priority review? It appears to have taken FDA only 6 months to review
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Dr. John Cush
Dr. John Cush@RheumNow·
Abbvie announced that the FDA has approved Rinvoq (upadacitinib) for use in adults with active ulcerative colitis (after failing TNFi); approval based on 3 endoscopic UC trials. Starting dose is 45 mg/d, then maintain w/ 15 mg (some can get 30 mg) bit.ly/37xK7x7
Dr. John Cush tweet media
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LipidLover MD
LipidLover MD@LipidLover1030·
Fantastic Kosh! Can’t wait to see your first published results! This shows us all in the US that it can be done easily and efficiently. (Embrace this “oh all ye who treat LDL-C.”)
Prof Kausik Ray FMedSci@ProfKausikRay

@LipidLover1030 @NMHheartdoc @dmljmd My first 20 have had excellent results. First pt dropped from 3.4 mmol/l to 1.7 in 11 days, peak reduction 1.6 at day 30, 1.8 at day 80. 10 more getting first shot shortly.

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John Kastelein
John Kastelein@JohnKastelein·
@ProfKausikRay And you have a great job Kosh with all the meetings , consensus statements and bringing Europe together under the EAS banner ! #
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Prof Kausik Ray FMedSci
Prof Kausik Ray FMedSci@ProfKausikRay·
2021 was my first as EAS President, a tough year for everyone around the world. We innovated finding new ways to collaborate & continue our mission. Wishing everyone a safe and healthy holiday season and best for 2022 eas-society.org/page/eas-presi…
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SEIS eSalud
SEIS eSalud@SEISeSalud·
En el proyecto ANJANA se han identificado 7 líneas de mejora en la ruta asistencial dl paciente SCS en el ámbito #TIC. Este proyecto ha sido desarrollado por la #SEIS, junto con #AMGEN y un grupo de especialistas cardiólogos. Más información en ow.ly/ySeR50GLapq
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Lorenzo Fácila
Lorenzo Fácila@mi_cardiologo·
Mecanismos de #inclisiran. Un fármaco que administrado cada 6 meses mejora el perfil lípidico de nuestros pacientes #mRNA Pendientes del estudio #ORION4 de morbimortalidad en diciembre 2024
Lorenzo Fácila tweet media
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CV Health
CV Health@CV_HealthNews·
@LipidLover1030 @drpablocorral Where did you hear a medical director from NVS mention a potential Lp(a) study? And were they referring to an Lp(a) study evaluating inclisiran or pelacarsen?
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LipidLover MD
LipidLover MD@LipidLover1030·
@drpablocorral According to a medical director at NVS, they will be pursuing an Lpa study in the future. While I appreciate the paper in general, it diminishes the broad implications for inclisiran before it is even on the market. It will and should change the course of ASCVD and LLT.
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Pablo Corral MD
Pablo Corral MD@drpablocorral·
Modern Approaches to Lower Lipoprotein(a) Concentrations and Consequences for Cardiovascular Diseases mdpi.com/2227-9059/9/9/…
Pablo Corral MD tweet mediaPablo Corral MD tweet media
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CV Health
CV Health@CV_HealthNews·
@Lpa_Doc What commercially available Lp(a) test kit would you recommend for clinical practice? And should we be measuring in mg/dL or nmol/L?
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Sam Tsimikas, MD
Sam Tsimikas, MD@Lpa_Doc·
NMR cant do it, it counts Lp(a) particles as LDL particles also.
Matt Martin@MattBMartin

@Lpa_Doc Sounds like it’s even more important to evaluate using NMR to separately measure those Lp(a) and LDL-P/ApoB particles.

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Jelajahi

@yicaichina @Novartis @NovartisScience @SABOURETCardio @michaelgitter @skathire @ambellinger @ASGCTherapy