Kristijan Ramadan Laboratory

This mechanism might regulate PARP inhibitor resistance: "Nucleophagy removes cytotoxic trapped PARP1". Nat Cell Biol. 2026 Jun 2. doi: 10.1038/s41556-026-01961-5. Thanks to all co-authors and collaborators for this discovery; It is highly appreciated.

Nucleophagy of DNA lesions also plays a role in the removal of trapped PARP1. Please check our manuscript posted on bioRxiv: biorxiv.org/content/10.648… A great deal of credit for this work goes to our former PhD student, Gwennie Hoslett.

@SPJacksonGroup @John_C_Fielden @jcornlab @Nature @ERC_Research Happy to see my ex-student is doing great. Well trained!

Thrilled to see this “veritable tour de force” led by @John_C_Fielden from @jcornlab out @nature,rdcu.be/ehd4E. This @ERC_Research funded project uses #CRISPRi to systematically scan 548 DDR genes for synthetic lethal interactions, ~150,000 pairwise combinations!

How does the SPRTN protease recognise DNA-protein crosslinks? This has now been resolved in our manuscript: biorxiv.org/content/10.110… The ubiquitin chains are the central regulators of SPRTN protease specificity and enzymatic activity towards DNA-protein crosslinks.

@iDikic2 @CellCellPress @IBC2_GU @FCI_health @proxidrugs @dfg_public @sfb1177 @sfb1361 @SFB1531 @uni_mainz_eng @goetheuni Congrats, Ivan. Great work.

How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 sciencedirect.com/science/articl…

We have a tenure-track professorship position in Cancer Biology focusing on genome stability, the ubiquitin system, and the animal/zebrafish cancer models: ntu.wd3.myworkdayjobs.com/en-US/Careers/…

@EMBOevents on the DNA Damage Response in Cell Physiology and Diseases starts this evening with keynote speakers Titia de Lange (@RockefellerUniv) and KJ Patel(@ketanpatelimmo1). If you're interested in a professorship in Cancer Biology in Singapore, please find me at the event.

@EMBOevents on the DNA Damage Response in Cell Physiology and Diseases starts this evening with keynote speakers Titia de Lange (@RockefellerUniv) and KJ Patel (@ketanpatelimmo1). If you're interested in a professorship in Cancer Biology in Singapore, please find me at the event.

Congrats to our former PhD student, Dr Susan Kilgas, on her first authored paper as a post-doc in @ChowdhuryLab/@DanaFarberHarvard/ @harvardmed on the role of the long non-coding RNA NEAT1 in the regulation of 53BP1 function: nature.com/articles/s4146…

@stagljar @iDikic2 @ProfIgorRudan Nice to see a strong CROSci team together, and in Croatia.

Study discovers new process for cells to repair DNA damage ntu.edu.sg/news/detail/st…

Hrvatski znanstvenici otkrili proces kojim se poboljšava postojeća terapija za karcinom debelog crijeva vecernji.hr/vijesti/hrvats…

Oxford and NTU Singapore Study discovers new process for cells to repair DNA damage oncology.ox.ac.uk/news/oxford-an…

Congratulations to our DPhil student Pauline Lascaux, all our lab members, and collaborators worldwide @NTUsg @NTU_LKCMedicine @OxfordOncology @institutrb @VdangioE3lab @nunoraimundo on the role of nucleophagy in DNA repair. Please check: doi.org/10.1016/j.cell…

I am thrilled to announce that today, we launched a Cancer Discovery and Renegenartive Medicine Programme at LKCMedicine-NTU-Singapore: ntu.edu.sg/medicine/resea… We are recruiting new faculty members, but please feel free to reach out if you are interested in our research vision.

DNA-PROTEIN CROSSLINKS in SINGAPORE Several post-doctoral positions will be available in my new lab at LKCMedicine/NTU in Singapore. Please check out these links: Senior Research Fellow: ntu.wd3.myworkdayjobs.com/Careers/job/NT… Research Fellow: ntu.wd3.myworkdayjobs.com/Careers/job/NT…

The Lee Kong Chian School of Medicine (LKCMedicine) is recruiting a junior principal investigator at the level of Assistant Professor in Cancer and Stem Cell Biology. Please check the call: ntu.wd3.myworkdayjobs.com/Careers/job/NT…

The Lee Kong Chian School of Medicine (LKCMedicine) is recruiting a junior principal investigator at the level of Assistant Professor in Cancer and Stem Cell Biology. Please check the call: ntu.wd3.myworkdayjobs.com/Careers/job/NT… A great opportunity to start an independent research career.

We also want to thank our great collaborators for their contribution to this work; Nancy Maizels and Kostantin Kiianitsa.

The lab is thrilled to see our Critical Reviews and Perspectives article on the isolation and detection of DNA-protein crosslinks: doi.org/10.1093/nar/gk… . We hope it will help scientists select the right DPC isolation assay to address their questions.