James Olzmann

1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳 nature.com/articles/s4158…

A first in class PTER inhibitor exhibits anti obesity activity (in mice)- and importantly, via a mechanism distinct from, and additive with, existing GLP1-RAs. Fun collaboration with Gray lab now out @CellChemBiol. Congratulations team! @Stanford_ChEMH cell.com/cell-chemical-…

The first approved GLP1 (Byetta) came from a desert reptile, the Gila monster. Inspired by this, our work on Burmese pythons 🐍🐍 is now out @NatMetabolism. An “extreme”-ly fun collaboration with Leinwand and @DrYongXu1. Congratulations @Shuke_Xiao! nature.com/articles/s4225…

Thrilled to be featured in the latest issue of Dystonia Dialogue! Our lab has been dissecting the genetic networks underlying dystonia, a severe movement disorder. Check out the article for a look at where our work is heading.

We are recruiting! If you are passionate about technology development, protein engineering, computational design, directed evolution, chemical biology - please reach out! (The setting is pretty nice too…)

Great to see a complementary screen from the @US_FDA identify #ferroptosis inhibition as critical for expanding human 🩸 #stemcells in @MolTherapy: cell.com/molecular-ther… Nicely supports our prior findings: nature.com/articles/s4155…

I’m excited to share new work out of the lab at @NYULangone led by @kenjifujihara! We took a first principles approach to evaluating #ferroptosis induction for cancer therapy via targeting the SLC7A11-glutathione-GPX4 axis. biorxiv.org/content/10.648…

💥New Article in FOS! Ferroptosis surveillance: Insights from in vivo contexts by Dr. Thales Papagiannakopoulos @ThalesPapaG team and Dr. Jessalyn M. Ubellacker from @HarvardChanSPH Please check the link🔗: sciexplor.com/articles/fos.2… #ferroptosis #cell #scienceresearch

Thanks to @NatureSMB for publishing a "Research Briefing" on our recent work, highlighting the discoveries and providing context on the story behind our research into how vitamin B2 metabolism regulates FSP1 stability to suppress ferroptosis.

New online! Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis dlvr.it/TRTVPq

3/3 Also exciting to see a complementary study from Pedro Angeli and team published in Nature Cell Biology today. Together, our studies highlight a role for vitamin B2 metabolism and FAD in regulating FSP1 and ferroptosis pathways. nature.com/articles/s4155…

2/3 Huge congratulations to the entire team for driving this project forward. Grateful for fantastic collaborators, including @PrattGroup and everyone in the lab who contributed to this work. A true team effort across genetics, cell biology, and chemical biology.

1/3 Thrilled to see our paper led by Kirandeep Deol is out! We used CRISPR screens to uncover regulators of the ferroptosis suppressor FSP1. key discovery: vitamin B2 metabolism stabilizes FSP1 via FAD, revealing a new way vitamins regulate ferroptosis. nature.com/articles/s4159…

New online! FAD-dependent stabilization of FSP1 promotes ferroptosis resistance dlvr.it/TRSYqP

🚨We’re getting down to the wire!🚨 We need 75 more gifts to unlock the final $57,000 in #CalBigGive matching funds. Every gift—no matter the size—helps us reach our goal. Join our final push by making your gift before 9 pm: givingday.berkeley.edu/giving-day/108…

Inspiration seminar from Mallika Singh, Senior Vice President at Revolution Medicines! Wow! 🤩

Great to welcome scientists from Amgen, Grifols, and Scribe Therapeutics to the @UCBerkeley MCB Industrial Affiliates Program symposium. Industry partners met with MCB grad students & postdocs, building bridges between academia and biotech innovation.

Evo 2, the largest fully open biological AI model to date, is now published in @Nature.

Very nice work on lipid droplets, FSP1, and ferroptosis in cancer cells from @PetanLab and colleagues. 👏 🤩

@PetanLab @FEBSJournal @OndrejKuda @FedorovaLab @Lejaperne Great to see this exciting work published! Congrats @PetanLab and team! 🎉

Excited to share our new paper in @FEBSJournal! With @OndrejKuda & @FedorovaLab we show how LDs reshape the lipidome of PUFA-exposed cells & shift function within the same cell, revealing a context-dependent role in ferroptosis. Congrats Ana & @Lejaperne! shorturl.at/TyRl1