Toni Petan

Excited to share our new paper in @FEBSJournal! With @OndrejKuda & @FedorovaLab we show how LDs reshape the lipidome of PUFA-exposed cells & shift function within the same cell, revealing a context-dependent role in ferroptosis. Congrats Ana & @Lejaperne! shorturl.at/TyRl1

Thrilled to share this #lipidtime story in @JCellBiol where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!

How does a cell remodel the ER membrane into a lipid droplet? Excited to share our new preprint. We find that regulated opening of the seipin ring defines a functional ER–lipid droplet interface — and identify SMLR1 as a regulator of this transition. biorxiv.org/content/10.648…

Excited to highlight our newest work “Lysosome-derived methylarginine is a signaling metabolite of the lipidome” (1 / 6) @NataliesWish nature.com/articles/s4155…

Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome | Nature Cell Biology nature.com/articles/s4155…

#Throwback COMMENT | KS Lee, X Su & T Huan Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics dlvr.it/TT7hgn

A new review from the lab on #LipidDroplet heterogeneity in Current Opinion in Cell Biology. Big thanks to Philippe Chavrier and Chris Fromme for organizing an exciting #Membrane Trafficking special issue! sciencedirect.com/science/articl…

The danger of reasoning by analogy: "The behavior of things on a very tiny scale is simply different. (Atoms) do not behave just like particles. The do not behave just like waves. Atoms do not behave like weights hanging on a spring and oscillating. Nor do they behave like miniature representations of the solar system with little planets going around in orbit. Nor does it appear to be like a cloud or fog of some sort surrounding the nucleus. It behaves like nothing you've seen before." Likewise, the cell is not a deterministic machine or factory. I think I can safely say that nobody understands the cell.

Artificial intelligence is not replacing human intuition in maths and physics, but reimagining how questions are asked, explored and understood go.nature.com/4aESYuz

Marjana Ndoci, @DeshwalSoni et al. show that #mitochondria prioritize survival over safety: when resources are low, they stop exporting Coenzyme Q to keep respiration running, at the cost of antioxidant protection. hubs.la/Q04kwgfH0 #CellMetabolism #Organelles

DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function dlvr.it/TSr75k

Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets | Nature Cell Biology nature.com/articles/s4155…

Please re-post! Time is almost up to register for the 2026 FASEB Lipid Droplet Meeting. Abstracts are due May 31, 2026. See link below, and join us for an amazing SRC lipid meeting July 26-30! #LipidSRC events.faseb.org/event/Lipid-Dr…

📖FOS New Mini-Review! “On the lethal mechanism of class III ferroptosis inducers” by Prof. Scott J. Dixon from @Stanford. Check to see why FIN56 causes ferroptosis but its analogs don’t. 🔗: sciexplor.com/fos/articles/f… #ferroptosis #Science #academic #cell

Fasting opens a metabolic window that favors anti-tumor immunity dlvr.it/TSWY8J

Great to see this Spotlight article in Trends in Cell Biology highlighting our recent identification of a lipid droplet quality control pathway in which FSP1 protects PUFA-rich neutral lipids from peroxidation, thereby suppressing ferroptosis. cell.com/trends/cell-bi…

You do not want to miss the 2026 FASEB #LipidDroplet conference! Abstracts are due May 31. Travel awards are available for trainees 👇

We are looking forward to this presentation by our colleague Dr Duško Lainšček as part of the #symposium we are organising in collaboration with the #CFGBC. Don't miss it Link: cfgbc.mf.uni-lj.si/events/2026cfg…

New! Online now: DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function dlvr.it/TS9Sb1

@cohenlaboratory Congrats, Sarah!!🎉🥂

I’m so happy to join the Editorial Board of JCB! Looking forward to handling your manuscripts

PLIN5 phosphorylation identified as a lever to tune hepatocyte lipid flux, suggesting therapeutic potential for targeting mitochondria–LD coupling #MASLD #MASH nature.com/articles/s4225…