Subham Das

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Subham Das

Subham Das

@_Subham_Das

PhD student @IISc Bangalore. Interest lies in 🦇#Cell death & Immunology.

Bengaluru, India Bergabung Ekim 2022
214 Mengikuti68 Pengikut
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Subham Das
Subham Das@_Subham_Das·
Cell death & Inflammation act like a double-edged sword in the clearance of viral infections. Do bats use it better than humans? Do check our recent review to learn how bats tolerate high viral loads without falling sick.@iiscbangalore @keshu_VRimmCh @Disha__dak @C_Priyansh
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The Times Of India
The Times Of India@timesofindia·
Pvt univs file more patents but IITs, IISc win more approvals Read more in today's Times Of India print edition 📰toi.in/epaper
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Kesavardan S
Kesavardan S@keshu_VRimmCh·
Our recent work on #DDX3Xsyndrome, a genetic neurodevelopmenetal disorder. We reveal how DDX3X syndrome mutations drive persistent, solid-like DDX3X-condensates assembly, promoting neuronal death and A-beta aggregation. biorxiv.org/content/10.648…
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Vijay Rathinam
Vijay Rathinam@RathinamVA·
Why does RNA undergo glycosylation? Excited to have our new paper out. We in collab w/ Ryan Flynn show N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells. nature.com/articles/s4158… @uconnhealth @UConnResearch
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Kesavardan S
Kesavardan S@keshu_VRimmCh·
Glad to have Kaushal visiting our Dept. Superb talk and interesting insights of bat immunity and zoonotic viruses. @BICS_IISc @sci_questions
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Kesavardan S
Kesavardan S@keshu_VRimmCh·
🦇 🦇 Bat viral RHIMs: Viral mimicry gone rogue.!!! 🦠 Check out this interesting interview of @SanchitaMishr20 from my group by @biopatrika. A lot to know about how bats promote pathogenic trait evolution in RNA viruses.! 🦇 @iiscbangalore @BICS_IISc
Biopatrika@biopatrika

#authorinterview @SanchitaMishr20 from @keshu_VRimmCh lab @iiscbangalore talks about her work on "Bat viral RHIMs: Viral mimicry gone rogue." Read more here biopatrika.com/academia/resea… via @biopatrika

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Kesavardan S
Kesavardan S@keshu_VRimmCh·
Why did 2.3.4.4b clade #H5N1 need a long stalk N1, unlike the previous clades H5N1s? We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.
Kesavardan S@keshu_VRimmCh

Why did the 2.3.4.4b #H5N1 become a #panzootic virus? Given its unprecedented spread, it's important to ask this Qstn. We reported last year, 2.3.4.4b H5N1 features long stalk N1, unlike prev clades. All mammals infected with H5N1 after 2020 (also B3.13&D1.1) show long stalk N1.

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Kesavardan S
Kesavardan S@keshu_VRimmCh·
We showed some time back 2.3.4.4b #H5N1 shows long stalk (full length) N1 (NA) in birds and mammals, unlike previous H5 clades , which preferentially paired with N1 with stalk deletions (short stalk). Glad to see another study with similar observations biorxiv.org/content/10.110…
Florian Krammer@florian_krammer

The first 'Vienna' paper is out. @enikohermann did a great job with that! journals.asm.org/doi/10.1128/mb…

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Kesavardan S
Kesavardan S@keshu_VRimmCh·
How does inflammatory cell death reveal insights about Bat viral tolerance? 🦇 🦇 Check out our interesting discussion. @sci_questions @BICS_IISc @iiscbangalore
ASM@ASMicrobiology

#MicrobiologyMonday: Bats are reservoirs for many viruses but don't get as sick as humans.🦇Why? It has to do, in part, with how bats regulate inflammation & cell death mechanisms, which are associated with virus-induced immunopathology in humans. #mBio: journals.asm.org/doi/10.1128/mb…

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Subham Das
Subham Das@_Subham_Das·
Reservoir host species (birds and bats) often stay asymptomatic compared to humans during viral infections. Regulation of multimodal cell death pathway (PANoptosis) in bats and birds contributes to their viral tolerance. #Anantika @keshu_VRimmCh mdpi.com/1999-4915/16/1…
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Jelajahi

@keshu_VRimmCh @mahipal_ganji @jbloom_lab @iiscbangalore @RanjanaNataraj @avinashkarkada @uconnhealth @UConnResearch