Berg Lab at UNC-CH 리트윗함
Berg Lab at UNC-CH
194 posts
Berg Lab at UNC-CH 리트윗함
I’ve never felt so much respect for someone in a floral fanny pack
Great @newsobserver photo of one of the many nurses on the front lines of this pandemic, at @UNC_Health_Care
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This is a really lovely thread, thanks @TanentzapfLab
@threadreaderapp unroll please
Tanentzapf Lab@TanentzapfLab
1. One of formative experience of grad school for me was when our lab moved across the hallway to a bigger space & I realised my research didn’t really matter in the grand scheme of science & that this actually made me love science even more. So here is a thread about that.
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WOW. Just wow. Is BCM Genetics the pinnacle of science nerd skit/video parody? Brings back memories. Way to go @PotockiMD and all others involved...
lorrie@PotockiMD
Finally uploaded! LabGuy Billie Eilish Parody #BillieEilish #BadGuy @billieeilish @amanda_braddock m.youtube.com/watch?feature=…
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Berg Lab at UNC-CH 리트윗함
“Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamental difference between genomic screening and genomic diagnostic testing. genomemedicine.biomedcentral.com/articles/10.11…
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@UNC_SOM also emphasizes SDofH, and students are actively engaged with underserved populations. They also do need to learn about modern technology and be part of the discussion about how/when it can/should be applied. Not saying they should sequence their own genomes though...
Sharon Plon@splon
@cecilejanssens We have a required full term course on social determinants of health and health disparities @bcmhouston As a geneticist totally agree with you that is more important than @EricTopol suggestion of everyone sequencing their genome.
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Berg Lab at UNC-CH 리트윗함
“My medical training was always tied to genetics. I grew up with genetics, you could say.” bit.ly/32KUA0J
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@jwbelmon When I see this I think:
1) some of these assertions may be wrong (how good is the supporting evidence?)
2) some of these might actually be part of the same phenotypic spectrum and not distinct disorders (lumping vs. splitting)
3) pleiotropy and variable expressivity are cool!
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I thought the actual responses (aside from the yes/no) were quite nuanced. The answer is clearly "it depends"...
Muin J. Khoury@MuinJKhoury
@Larry_Svenson @CaulfieldTim @ConversationEDU Perhaps they can ask 5 more experts!
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@A_Elhabyan @ClinGenResource Volunteers can complete a questionnaire here: docs.google.com/forms/d/e/1FAI…
It will get some info about your background and your interests, and then ClinGen staff will match you up with opportunities to contribute as a curator.
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You can be the 1000th member of ClinGen! Volunteer now: clinicalgenome.org/start/
#CCG19
Nick Lench@njlench
#CCG19 Ever expanding influence and contributions worldwide - great effort!
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Use of genomic screening in newborns and children requires careful thought about what information to include. NC NEXUS used "age-based actionability" to help categorize conditions for parental decision-making. authors.elsevier.com/a/1Z5eG_WXIBsL… @NICHD_NIH @UNCResearch
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Who knew people could mis-use genetic tests? 🙄
Any guesses as to what "genetic condition" this guy was diagnosing based on 23andMe in order to gain exemptions? MTHFR, anyone? thevaccinereaction.org/2017/05/mthfr-… #psuedoscience #pseudomedicine
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Cautiously optimistic about therapeutic intervention in Huntington disease. Exciting to see reduction in mutant HTT in CSF after intrathecal antisense oligo, but looking forward to Phase 2/3 trials studying outcomes & prevention of manifestations.
Muin J. Khoury@MuinJKhoury
Some hope for patients with Huntington's disease: Targeting Huntingtin expression. Via @NEJM. nejm.org/doi/full/10.10…
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@RobertCGreen @TheACMG @RobertCGreen do you agree that if @TheACMG were going to make recommendations about population screening they would likely need to use a very different process than the one that was used for secondary findings?
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On one hand, @theacmg statement highlights that secondary findings (aka opportunistic screening) has limited evidence for benefit. But, also seems shortsighted resistance to natural evolution toward universal genomic medicine research RoR in TOPMed, All of Us, MyCode and others.
Robert C. Green@RobertCGreen
Today #DNADay19 @TheACMG discouraged using "ACMG59" around screening tinyurl.com/y3qoukse (even trademarking it!). Important to distinguish OPPORTUNISTIC vs POPULATION screening (tinyurl.com/y6f48e2x) but @ACMG statement ignores growing evidence for screening benefits!
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The distinction is between what genes were deemed by the ACMG Secondary Findings working group to be important enough to look for when someone undergoes clinical genomic sequencing for diagnostic purposes, versus those that should be actively sought in the general population.
Kyle W. Davis@kylewalterdavis
@elise_fiala @AlexisCarere Perhaps @BergLabUNC has some input on this? He and I had a good convo about screening for these kinds of genes at #ACMG19.
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Haven't read the book, but quotes from the review ("geneticist Robert Plomin ...presents DNA as a “fortune-teller” that is “100 percent reliable” and that can “predict your future from birth”) make me cringe. Hard to fathom anyone making claims that mutilate our science this way.
Cecile Janssens@cecilejanssens
"No matter how good our understanding of the genetics of intelligence gets, we will never be able to predict intelligence of individuals with accuracy from genomic information." says @WiringTheBrain Never accurate. Not even close. blogs.scientificamerican.com/observations/i…
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@dannydesloover The question is about who you target your interventions to, before they get obese. If you just pick the top decile you will fail to intervene on the majority of kids who will become obese. A population-level program would target everyone for a more healthy lifestyle.
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@BergLabUNC I don't think anyone is suggesting ignoring the severely obese kids. It's about rank ordering, and providing additional context and education.
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The problem with focusing intervention on the top decile of PRS is that it would ignore the majority of kids who will be overweight, obese, or severely obese, but who have a "normal" PRS (~82%, 79% and 68%, respectively)...
Sek Kathiresan MD@skathire
@GENES_PK @WBUR Is your suspicion population-level programs > impact than targeting high genetic-risk kids based on evidence (i.e., proven efficacy of population-level programs for obesity) or just a hypothesis?
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