Kohli Lab
114 posts
@KohliLab
Studying DNA-modifying enzymes & pathways that add complexity to genomes. Tweets crowdsourced from overworked lab members & not Rahul Kohli unless tagged #RMK.
The last lead author article from my PhD is out! In @NAR_open, we report our mechanistic study on how Cas9 and AID enzymes collaborate to shape base editing outcomes. Leveraging these insights, we create hyperactive BEs with the potential for targeted gene diversification. 1/
This work involved talented young scientists like @EricKofman and @pratibhajagann_ and was a collaboration with @KohliLab and @KomorLab. It allowed me to apply mentoring skills gained through my @SD_IRACDA training while supervising undergraduates who made valuable contributions.
@NoaErlitzki @KohliLab @PeterFBailer @bricruga @CaseyMogilevsky THANK YOU!!! I will be posting tomorrow; we're getting closer to another 30! Tell the other labs to be as cool as you and #RideTheSHOTWAVE!
(1/5) Delighted to share my work in concert with co-first author @MarkAHix where we used combined computational and biochemical approaches to interrogate the active site of a carboxymethyltransferase (CxMTase) out now @ #ACSChemBio (DOI: doi.org/10.1021/acsche…).
