Mitchell Leshchiner
642 posts




CENTCOM chief Brad Cooper: “There's been no better teammate than Israel.”

If you want to succeed with an early-stage startup, your best move might be far away from Silicon Valley, to a small city with an active startup community of its own.


Bloodletting for fever. Confident. Standard practice. Mercury tablets for syphilis. Confident. Widely prescribed. Radium water for low energy. Confident. Sold in pharmacies. Lobotomies for anxiety. Confident. Won a Nobel Prize. Thalidomide for morning sickness. Confident. Distributed to millions. Cigarettes for throat irritation. Confident. Doctor-endorsed advertising. Heroin for coughs. Confident. Marketed by Bayer. DDT sprayed in children's schools. Confident. Government-approved. Margarine instead of butter. Confident. Heart-healthy alternative. Dietary fat causes heart disease. Confident. Fifty years of guidelines. Statins for everyone over fifty. Confident. Best-selling drug in history. Seed oils are safe. Confident. Endorsed by every major health body. Meat is carcinogenic. Confident. WHO classification still stands. Every generation of doctors was confident. Every generation was wrong about something they were certain of. The question isn't whether to trust doctors. The question is which part of the current list turns out to be the thalidomide.






Celebrating our first close of Brickyard Fund II.


I think peptides are popular because they give people a feeling of power and control. One feels helpless when they can't sleep, stop scrolling, eat well or exercise consistently. A few injections wrestles back a feeling of control. Evidence shows that injections amplify perceived agency (the ritual potency of administration). This creates a dangerous situation where powerful compounds are being used less for biomarker improvement and more for psychological wellbeing. This is what you want: closed loop. > intervention (peptide) > biological change > measured biomarker > adjustment How most people are using peptides: open-loop. > intervention (peptide) > subjective feeling > more intervention The open-loop compounds over time. Without biomarker feedback, dose escalation is driven by subjective feelings which creates increased risk of doses with no clinical precedent. I am pro peptide and pro experimentation. Some peptides such as GLP-1s and similar are among the most effective in the world. Peptides (without clinical data) are among the most promising therapies available. They also need more clinical work so that we can characterize their effects, both good and bad. Nothing is free in biology.













