Paul Ostergaard

You’re still mixing categories. I said optic nerves aren’t brain cells. A nerve is a bundle of axons, not a cell. That’s basic biology. Yes, it’s CNS tissue. No, that doesn’t make it a “brain cell.” More importantly: the Yamanaka factor work you’re pointing to (e.g. @davidasinclair ) is not about general brain repair. The only place this has translated toward humans so far is: -> retinal ganglion cells / optic nerve (vision loss, glaucoma) Why? Because the eye is: •accessible •measurable •lower risk So: •CNS tissue? Yes •Brain cell? No •Evidence for whole-brain regeneration and potential risk factors arising as you flagged in your original post? Not even close.

It’s funny. The optic nerve is technically an extension of the brain. Optic nerves are as “brain cell” as any other cell in the CNS. These cells have limited ability to repair themselves, due to their regenerative properties being somewhat limited. The optic nerve is the cranial nerve II; it is fundamentally different from peripheral nerves. Peripheral nerves can heal much faster. Additionally: It’s not myelinated by Schwann cells but rather by oligodendrocytes which are the exact same glial cells that myelinate the brain and the spinal cord. Tl;dr actually, optic nerves are a part of the brain.

@parmita Optic nerves not actual brain cells.

This is not true! Firstly, it is absolutely implied that this is a first pass for then moving into age related brain diseases like Alzheimer’s. Secondly, there’s a lot of work on partial reprogramming in brains by Sinclair and otherwise! (See screenshots for a few off the top of my head; the science one is huge.) Thirdly, by definition RGCs already do technically take us into nervous system territory. But even outside of this, cognition is absolutely a focus.

@parmita @hernangraffe Wut? Literally no-one serious is discussing reprogramming brain cells with Yamanaka factors.

Resetting the epigenomic clock can require changes in who you are in ways that people might not want to go down. The cost of reprogramming is not just cancer risk or loss of cell identity. It may be the loss of self. We don’t have the map for partial reprogramming. 🧵

@MatthewBerman 🙏🏻

Looking for some agent-addicted people to test a new project I've been working on. Comment below and I'll send you access.

@weswinder Love it.

wow. only real people can reply to this no more ai bots allowed

@Yuchenj_UW Yo.

hey friends! 👋 Only cool people are allowed to reply to this tweet obviously.

@tunguz GM

gm if you can reply to this you are awesome

@Trade_EU @EU_Commission @vonderleyen @EUinAus @MarosSefcovic @AustraliaEU @EU_Taxud @EU_Growth @EUAgri @olofgill Awesome outcome.

We have a deal 🇪🇺🇦🇺 Read more: link.europa.eu/8cFfNW #EUTrade #Australia #TradeDeal

@venturetwins Yes please

Truly blown away by a new AI image model launching this week ✨ Finally, you can generate photos that actually look like you! It's so much better than everything I've tried - from LoRAs to NB Pro. Onboarding some early testers. DM or comment if you want access 👀

@mckaywrigley 👋

looking for a handful of people to test something new... i've been using it for a few months and am prepping to share. if you're a fan of claude cowork, openclaw, manus, perplexity computer, etc then you're a perfect fit. this will self destruct in 4hrs - please dm or reply.

@arankomatsuzaki Amazing.

For about six months, my mom had severe hepatic encephalopathy—at times it looked like she might not survive. I’m not a doctor, but I kept detailed notes and ran them through GPT-5.x Pro for every new update. At one point it suggested spontaneous porto-systemic shunts (SPSS), which I’d never heard of. I raised it with her hepatologist, and it was confirmed. The standard BCAA she’d used before (Aminoleban) didn’t work this time unlike the last time. After he prescirbed a different type, she improved significantly. More importantly, we finally had a clear root cause—no more blind trial and error, just well-understood options. She’s now fully recovered, with no noticeable aftereffects, which still feels remarkable given how bad things got.

@SleepMoneyMaker @garrytan Late to this. How to get started?

You'll get addicted if you try this just once: /gstack run office hours on my codebase (h/t @garrytan)

@MatthewBerman Cute…

Fine tuning from my phone is insanely satisfying

@Kyrannio Awesome!

Today’s a big day here at Pokee for all of you who are fans of OpenClaw! 🦞 Really excited about this launch and proud of the team, they’ve put a lot of work into secure sandboxing and easy setups! Can’t wait to see what you’ll all build with this :)

@DeryaTR_ Incredible times...

In just two days, using OpenAI Codex app GPT-5.4, I created a fully functional flow cytometry data analysis software, ~20,000 lines of code from scratch! This is a highly sophisticated and specialized biology software tool that every immunologist relies on. The best part is that I can continuously improve it and add new features that are not even available in comparable commercial software, which can cost thousands of dollars per user! For those not familiar with what flow cytometry software is, here is the detailed explanation from Grok: Flow cytometry analysis software is like a super-smart graphing calculator for biologists and doctors who study cells. What the machine does firstImagine you have a sample of blood or tissue with millions of cells. The flow cytometer machine lines the cells up single-file like cars on a highway and shoots lasers at each one as it zooms by (thousands of cells per second). The lasers tell the machine things like:How big is the cell? How “grainy” or complicated is it inside? Does it have certain “flags” (proteins) stuck on it? (These flags light up in different colors, like red, green, purple tags.) The machine spits out a huge computer file full of raw numbers — no pictures, just data. What the software is forThe analysis software takes that messy pile of numbers and turns it into clear pictures and answers you can actually understand. Think of it as the “translator” or “artist” that draws the story from the data.With a few clicks you can see:Colorful dot plots or graphs that show different groups of cells (like “these blue dots are healthy immune cells, these red dots are cancer cells”). Exactly what percentage of the cells are a certain type (e.g., “78% of the cells in this blood sample are fighting the infection”). How strongly a cell is “glowing” with a certain color tag (which tells you how much of a protein it’s making). Side-by-side comparisons of a patient’s sample before and after treatment. The magic trick scientists use every dayThe most common thing they do is called “gating.” It’s like drawing a circle around a group of similar dots on the graph and saying, “Only look at these cells.” The software instantly counts everything inside that circle and gives you the numbers. You can keep drawing smaller and smaller circles to zoom in on very specific cell types — kind of like zooming into a crowd photo until you only see people wearing red hats and glasses.

@DeryaTR_ @NotebookLM Love this, Derya.

Here is part 2 of my plumbing training videos created by @NotebookLM. My goal is to show that it is now possible to create AI training videos on pretty much anything. These will be incredibly useful for apprentices and hobbyists. In the age of AI, you can learn and do anything!

@ah20im Do tell!

Exciting times ahead indeed

@MagaGrunt1 @grok, is this an AI generated video? (Checks sunglass reflections)

🇺🇸The left is wrong. United we stand behind our law enforcement.🇺🇸

@sama @DanielleFong Hmm…

I have so much gratitude to people who wrote extremely complex software character-by-character. It already feels difficult to remember how much effort it really took. Thank you for getting us to this point.

@romainhuet @levelsio Can’t wait. This is the biggest gap currently.

@levelsio I think Codex users will like what we’re cooking for this 🙂 Coding on the go is awesome. I haven’t tried the dentist yet. Need to step up my game!

Are you guys aware I am coding mostly on my phone now all day via Termius to Claude Code on my server while I go with gf to the dentist, clothing store, cafe, etc. 😛✌️