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100xrunner

@100xrunner

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Katılım Ocak 2026
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Crypto Bitlord
Crypto Bitlord@crypto_bitlord7·
Psilocybin potentially has negative effects on testosterone. You’ll notice hippies are always weak ectomorphs. Not a coincidence is it? Your food directly impacts your health.
Bryan Johnson@bryan_johnson

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

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Mimi J
Mimi J@TheKanehB·
Stop w this “world is ending” Abrahamic belief It’s ending for THEM, not you. They need u to manifest the destruction for them; don’t. The system is ending, not the world. U can live without the system, i promise
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Grummz
Grummz@Grummz·
It's just going to get weirder and weirder and weirder... "This is what it's like when a species prepares to depart for the stars" "You don't depart for the stars under calm and orderly conditions. It's a fire in a madhouse." The mushrooms were right.
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parks
parks@parkersity_9·
No one wants to work anymore because there is no reward. Half of us are living paycheck to paycheck. No saving for retirement. No saving for a house. Straight up two paychecks away from living on the street.
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Sophia ❣️
Sophia ❣️@KeruboSk·
Millennials are the elite generation because they cranked out 12-page essays the night before they were due. No ChatGPT. No Claude. Just lo-fi beats playing in the background, Black coffee at midnight, footnotes that were somehow correct, and pure delusion. Grade was an A minus. Period.
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100xrunner
100xrunner@100xrunner·
@DeryaTR_ And 15 people will benefit from it the rest will starve to death nice
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Derya Unutmaz, MD
Derya Unutmaz, MD@DeryaTR_·
In the next 2–3 decades, we’ll achieve more technological progress & economic growth than in the entire history of human civilization! Since the dawn of civilization, we’ve created ~$6 quadrillion in wealth cumulatively. By 2050s, we’ll generate another $6 quadrillion in wealth!
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100xrunner
100xrunner@100xrunner·
@Microinteracti1 How the fuck did they not think about heat signature bedore this? I don’t believe it
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Gandalv
Gandalv@Microinteracti1·
The F-35 was supposed to be unkillable. That was the whole point. Lockheed Martin spent thirty years and four hundred billion dollars, the most expensive weapons programme in human history, building an aircraft that the enemy simply could not see. Not on radar. Not on infrared. Not on anything. The F-35 was not just a fighter jet. It was a theological statement. America’s way of saying: we have moved beyond the reach of your missiles, your sensors, and your prayers. Iran apparently didn’t get the memo. Somewhere over Iranian airspace on March 19, 2026, an IRST system, infrared search and track, the kind of sensor your grandmother could probably explain, looked up, found the F-35, and locked on. Not because Iranian engineers are geniuses. Because the F-35, it turns out, is extremely hot. All that engine. All that thrust. All that carefully sculpted stealth geometry, and the bloody thing glows like a kettle. The heat signature data Iran now holds is not just embarrassing. It is a gift that keeps giving. To Moscow. To Beijing. To every procurement ministry on the planet that has been quietly wondering whether to spend the money on systems designed to kill this aircraft. The answer, as of this week, is yes. And here is the bit that should really worry the Pentagon. You can patch software. You can redesign coatings. You cannot reprogramme a pilot’s brain. Every F-35 driver who takes off from here on knows, actually knows, that someone down there might be able to see them. That changes everything about how they fly. Caution replaces aggression. Hesitation replaces instinct. Four hundred billion dollars. And in the end, it was done in by a heat sensor. Tremendous. Gandalv / @Microinteracti1
Gandalv tweet media
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Aureus Arena
Aureus Arena@AureusArena·
@andyfang Anyone who does this, just know you are training your replacement that will never get tired, never complain, never takes breaks, all this data is being collected for pennies on the dollar, if you knew your worth you would avoid helping them but you will most likely be a pawn.
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Andy Fang
Andy Fang@andyfang·
Introducing Dasher Tasks Dashers can now get paid to do general tasks. We think this will be huge for building the frontier of physical intelligence. Look forward to seeing where this goes!
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Gopicco
Gopicco@gopicco23·
@Xking332 Bitcoin will survive but it will be close to $0 if your scenario plays out.
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X@Xking332·
Soon there won’t be food. There won’t be fuel. Stocks will go to zero. Most metals will go to zero. Everything you thought was safe gets wiped out. Bitcoin will survive. The middle class will be crushed. People won’t even be able to afford to eat. They will be hungry for weeks. Companies will go bankrupt. Jobs will disappear. And when people get desperate, crime will go up. There will be murders and robberies. And the system will normalize them. Governments will convince you it's ok. This is the collapse phase. We’re heading straight into one of the darkest periods of humanity. The only way out is the war has to end before it's too late.
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100xrunner
100xrunner@100xrunner·
@Xking332 We’re at the end of the Kali Yuga bro. Just aftershocks. We’re almost out.
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Peter
Peter@Onepeterrr·
What has been your biggest roundtrip since you’ve Crypto 🤔
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100xrunner
100xrunner@100xrunner·
@rushicrypto It won’t even be in the history books, the real resets are hidden
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Rushi
Rushi@rushicrypto·
If the last one was named “The Great” Depression, what’s this one going to be called?
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100xrunner
100xrunner@100xrunner·
@gothburz @saishooonohebi Proof you don’t understand bitcoin. Bitcoin is the server that can’t be turned off. The metaverse is data stored on chain.
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Peter Girnus 🦅
Peter Girnus 🦅@gothburz·
My net worth peaked at $1.2 million. None of it was real. I don't mean that philosophically. I mean it was located on servers that have since been turned off. I own eleven properties in the metaverse. Three in Decentraland. Four in The Sandbox. Two in Voxels. One in Otherside. And a beachfront villa in Horizon Worlds that I bought for $214,000 because Mark Zuckerberg called it "the next frontier." The frontier closed last week. It's a mobile app now. Last year I mass DM'd 340 people the phrase "you don't understand how early we are." I have since stopped doing that. Not because I was wrong. Because most of them blocked me. I got into metaverse real estate in November 2021. Everyone was buying. Someone paid $450,000 to be Snoop Dogg's neighbor. In a video game. With no legs. The avatars didn't have legs. I thought that was bullish. "The legs are coming," I told my Discord. "Legs are a roadmap item." Three hundred people reacted with rocket emojis. I called myself a "digital land baron." I put it in my Twitter bio. I put it in my LinkedIn headline. I said it on a podcast that had eleven listeners. Three of them were bots. The rest were my alts. My virtual property has more square footage than my actual apartment. My actual apartment has furniture. Location, location, location. My most valuable asset was a plot next to a virtual Gucci store. Gucci left in 2023. The store is still there. Nobody's in it. It's like a mall in Ohio but with worse graphics and no food court. I held. Diamond hands. That's what we said. "Diamond hands." It means refusing to sell while your investment loses 94% of its value. We turned financial paralysis into a personality trait. A guy in my Discord paid $2.4 million for a 618-parcel estate in Decentraland. Prime district. High foot traffic. I asked him what "foot traffic" meant when the platform had 38 daily active users. He said I didn't understand the technology. I didn't. I still bought more. We had a DAO. A decentralized autonomous organization. That means we voted on decisions. There were nine of us. Three never showed up. Two voted on everything without reading it. The other four were me and my alts. We voted to "acquire strategic parcels." The vote passed unanimously. I voted four times. My portfolio peaked at $1.2 million. I told everyone. I made a spreadsheet. I projected 40x returns by 2025. I made a pitch deck. The pitch deck had a slide that said "WE ARE BUILDING THE DIGITAL ECONOMY." The slide had a rocket emoji. That was my entire financial model. In 2023 I bought a Bored Ape for $189,000. It's worth $14,000 now. I don't talk about the Ape. I still use it as my profile picture. People ask me about it. I say "I'm long-term bullish." Long-term bullish means I can't sell it without crying in a Panera. My mom asked me what a Bored Ape was. I said "digital art on the blockchain." She asked why it cost more than her car. I said "you don't understand Web3." She said "I understand you live in a studio apartment." She's not in my Discord. Justin Bieber bought one for $1.3 million. It's worth about $90,000 now. I felt better about mine after I heard that. That's community. WAGMI. We're All Gonna Make It. We said that every day. In the group chat. While the floor dropped. While the volume dried up. While 95% of all NFT collections went to zero. We're all gonna make it. None of us made it. But we said it with conviction and a laser-eye profile picture. That counts for something. It doesn't. But we said it did. That's decentralized consensus. Meta spent $84 billion on the metaverse. I need to say that again. $84 billion. More than the GDP of Luxembourg. More than the GDP of Iceland, Luxembourg, and Malta combined. They spent it on a platform where the avatars had no legs, the graphics looked like a 2006 Wii game, and the peak user count was lower than the lunch rush at a Chipotle in Des Moines. They just pulled Horizon Worlds from VR headsets. It lives on as a mobile app. My beachfront villa is now a mobile app. Location, location, location. Zuckerberg renamed the entire company for this. Facebook became Meta. A $900 billion company changed its legal name because the CEO watched Ready Player One and said "I want that." Reality Labs lost $10 billion in 2021. $14 billion in 2022. $16 billion in 2023. $18 billion in 2024. $19 billion in 2025. That's not a strategy. That's a speedrun. They laid off 1,500 Reality Labs employees this year. Shut down three VR studios. Killed Supernatural. Put the entire VR social vision in a casket and said "we're pivoting to AI and wearables." The pivot took four years and $84 billion. I pivoted too. I'm an AI real estate investor now. I bought a virtual plot in an AI-generated world that doesn't exist yet. The founder said it was "the intersection of spatial computing and large language models." I don't know what that means. I gave him $40,000. He has a whitepaper. It's 47 pages. I read the title and the tokenomics section. The tokenomics section is a pie chart. I love pie charts. They make everything look like a plan. The project has a roadmap. Q1: "Build community." Q2: "Launch beta." Q3: "Scale ecosystem." Q4 is blank. Q4 is always blank. That's where the exit scam goes. My accountant asked me to value my metaverse portfolio for tax purposes. I said $1.2 million. He said "current market value." I said $6,400. He stared at me for eleven seconds. I know because I counted. He asked if I had any other investments. I showed him my NFTs. He stared for longer. I told him they were "cultural artifacts with long-term provenance." He asked if I'd considered a 401k. I told him a 401k was "legacy finance." He told me to leave his office. The metaverse is dead. I don't accept that. I am a digital land baron. I own eleven properties across four platforms. I have a beachfront villa in a mobile app, a plot next to an empty Gucci store, and a cartoon monkey that cost me more than my actual car. Location, location, location. The location is nowhere. But I'm early. I'm always early. That's the same as being wrong except you get to say it with confidence.
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100xrunner
100xrunner@100xrunner·
@NumberGoUpTech @NoahRyanCo For this scenario yes. My mold situation was different. Zero visible mold. It had colonized the inside of the AC unit and it was behind the walls. Impossible to see.
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Number
Number@NumberGoUpTech·
@100xrunner @NoahRyanCo Let’s keep it in context. Visible mold was found under the sink. Bro would have known immediately not to lease the place had he done the most basic check.
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Noah Ryan
Noah Ryan@NoahRyanCo·
Move into new rental. Nose gets stuffed. Then vision gets blurry. Then words start slipping my tongue. Peek in the mirror and I look hungover. Feels like I got a concussion. Look in the cabinets, mold everywhere. Florida.
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100xrunner
100xrunner@100xrunner·
@NumberGoUpTech @NoahRyanCo visual checks fail - i lived in a completely infested moldy house without seeing a single colony with my eyes. you need to do an ERMI/HERTSMI2 test. Not even a air spore count can give you enough information. $350 minimum for every house before you even move in.
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100xrunner
100xrunner@100xrunner·
@_6signxxx That weapon can be purchased legally for $2000 anywhere
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Number
Number@NumberGoUpTech·
@NoahRyanCo Do you not check all this stuff before you make the move? Where’s the due diligence
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