SeHee Park

31 posts

SeHee Park

SeHee Park

@1211spark

Postdoc @JoungLab at MGH and HMS | PhD Beal Lab at UC Davis | CRISPR, RNA Editing

Boston, MA Katılım Ocak 2016
172 Takip Edilen139 Takipçiler
Julian Grünewald
Julian Grünewald@grunewaju·
Very excited about the first preprint from our lab @TU_Muenchen! This is a fun gene & cell therapy collaboration led by @SchmidtsAndrea's Lab. We use generative #AI to design new #CARTcell therapies. Check out Andrea's thread & thanks to the whole team! biorxiv.org/content/10.110…
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Andrea Schmidts@SchmidtsAndrea

Cancer escapes immunotherapies by mutating its surface. This means even groundbreaking #CARTCell therapies fail too often because of cancer resistance. But what if we could use #GenerativeAI to design CAR-T with de novo binders faster and smarter, targeting even resistant tumors? In the first preprint from my & @grunewaju's labs @TU_Muenchen, we show how this could work for new #celltherapies and #genetherapies. (1) 🧵biorxiv.org/content/10.110…

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Julian Grünewald
Julian Grünewald@grunewaju·
Extremely excited to kickstart my lab @TU_Muenchen with Emmy Noether support from @dfg_public. I’m very grateful to @JKeithJoung, my friends in Boston, and to A. Moretti, K.L. Laugwitz & C. Kupatt in Munich. More details & website coming soon. #CRISPR 🫀
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Andrea Schmidts
Andrea Schmidts@SchmidtsAndrea·
Monday was my last day @MarcelaMaus Lab and @MGHCancerCenter. Feels surreal to be leaving after 4 wonderful years. I’ve learned so much + am deeply grateful for Marcela’s outstanding mentorship & the friendships with my fantastic Maus Lab colleagues. More soon on my next steps…
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Julian Grünewald
Julian Grünewald@grunewaju·
Monday was my last official day @jounglab. I’m beyond grateful to @JKeithJoung for his outstanding mentorship and to the entire lab- you’re such a wonderful bunch of people. I’ve found so many friends and learned so much. Excited about the next steps, but first...
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ESGCT
ESGCT@ESGCT·
ESGCT Young Investigator Award In this post we will be explaining a little about an award that we present each year at our congress. You can find a full breakdown of the awards on our website: esgct.eu/About-ESGCT/Aw… Haven't Registered yet? Head over to esgct.eu🧬
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Fyodor Urnov
Fyodor Urnov@UrnovFyodor·
Yay! The family of editors being real-world-tested welcomes editing of RNA. The underlying science is elegant; like genome editing, a collaboration with Mother Nature - but a different facet of her. See Pubmed 30737497 👏 @prashantgmali @MaxGelman endpts.com/exclusive-roch…
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J. Keith Joung
J. Keith Joung@JKeithJoung·
Congrats to first-author Esther Tak @taktak309 and co-authors (@joyehorng @ntperry13 Hayley Schultz @becauseBiology @freakyao Luli Zou @MartinAryee @lucapinello) on the publication of our newest paper in Nature Methods (free link: rdcu.be/csoDt). Will tweet summary soon
Nature Methods@naturemethods

The @JoungLab reports that long-range CRISPR activation can be enhanced by concurrent recruitment of artificial TFs to the enhancer and promoter of a target gene. @JKeithJoung nature.com/articles/s4159…

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Kiran Musunuru
Kiran Musunuru@kiranmusunuru·
A milestone in modern medicine: 1st therapeutic in vivo gene editing in human patients! From Julian Gillmore, @intelliatweets & colleagues out today @NEJM: nejm.org/doi/full/10.10… Here’s an overview of a new potential treatment for transthyretin (ATTR) amyloidosis. (thread)
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J. Keith Joung
J. Keith Joung@JKeithJoung·
Excited to share that our collaboration with the labs of Joanna Yeh and @MarcelaMaus of @MGH_RI was published online today in @NatureBiotech describing the use of CRISPR prime editors as ribonucleoprotein (RNP) complexes in zebrafish and human cells (1/2) twitter.com/NatureBiotech/…
Nature Biotechnology@NatureBiotech

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells go.nature.com/336sL4V

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Croix Laconsay
Croix Laconsay@CroixLaconsay·
Excited to share the work I did with Dibyendu Mallick and Sason Shaik at @HebrewU. The Cope rearrangement of semibullvalene is a textbook physical organic reaction, which we predict can be interrupted with electric fields. Thank you @FulbrightPrgrm for the scholarship! #compchem
J Org Chem/Org Lett@JOC_OL

Now in #JOC: External Electric Fields Interrupt the Concerted Cope Rearrangement of Semibullvalene, a new twist on a classic physical organic reaction by @CroixLaconsay with Dibyendu Mallick and Sason Shaik. Check it out: doi.org/10.1021/acs.jo…

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SeHee Park
SeHee Park@1211spark·
My research paper on ADAR1 is finally out in @NatureComms today! Please check it out to learn about the novel zinc binding site we discovered and structural models of ADAR1 deaminase domain. Huge thanks to everyone who contributed to this work! doi.org/10.1038/s41467…
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Leanna Monteleone
Leanna Monteleone@LeannaMonteleo1·
Amazing! So glad to see this work awarded for the Nobel Prize in Chemistry! Having the chance to see Prof. Jennifer Doudna present at the @UCDChem Miller Symposium was an absolute joy! @agya_karki @Ee_Doherty @1211spark @xewilcox @kev_m_ph @peterabeal
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The Nobel Prize@NobelPrize

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

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SeHee Park
SeHee Park@1211spark·
Please check out our recent published paper on ADAR2 dimer structure! Excited to be a part of this work! Congrats, Alex and everyone!! doi.org/10.1093/nar/gk…
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Keşfet

@grunewaju @TU_Muenchen @SchmidtsAndrea @Karl_Petri @Uniklinikum_Wue @Uni_WUE @dfg_public @Myeloma_Society