Synek

This was the most profound experience of my life. I am stunned beyond comprehension. This molecule is without peer. The 27mg dose opened up what felt like pure consciousness and intelligence. A majestic reveal of existence itself. In all its incomprehensible glory and majesty. It is impossible to explain with words. Whatever you imagine, multiply it by 1,000 and then add infinite width and depth and dimensions. But entrance was not granted without prerequisite. Existence demanded that I submit. That I say yes; without attachment and without condition. Yes to existence; yes to the dissolution of self; yes to release control; yes, to all. My ego registered the ask and panicked. It wanted control. It was desperate for control. It pleaded to escape from the torrent of light and essence that threatened to rip my sanity into chards. The urge to eject was overwhelming. Terror thundered throughout my mind and body. It took everything within me to release. I overcame and was treated with bliss that defies imagination. A euphoria colored with perfect harmony of all things. An orchestra of essence washed over me and swept me up in dance. It was home. The highest aspiration of intelligent life. For some reason, stored and tucked away as the ultimate prize. A single concept emerged in omnipresence: we cannot grok the preciousness of our existence. Yet it is everything we’ve ever wanted and more. The state we long for without knowing it exists. This caused me great pain and heartache. A swell of loyalty and devotion emerged inside me, pledging allegiance to existence. To become a warrior and caretaker of life on earth. To protect at any cost the candle of consciousness that has miraculously emerged in this part of the galaxy. What awaits will wipe all your tears, soothe all your sorrows, and infinitely exceed your wants.

the weird thing about the bryan johnson 5meo stunt is that he already has the molecule tattooed on his body and he's larping as though it's his first time

My psychedelic tier list: S-tier: LSD, Huachuma, 5-MeO-DMT A-tier: Ayahuasca, Iboga, nn-DMT, Psilocybin Mushrooms B-tier: MDMA, Ketamine, Cannabis (high dose), 2C-B C-tier: Datura, Salvia, Kambo D-tier: Most research chems, bad ceremonies, fake shamans, commodifying entheogens What's yours?

Gut inflammation hurts digestion, sure, but it also collapses your brain’s field of awareness. You basically become semi-retarded. Let me help you. Bacterial endotoxin and serotonin from the intestine block cellular energy production, forcing cells into stress chemistry. The brain feels this as narrow, anxious, tunnel-like thinking. It can be horrifying and isolating. When energy metabolism falters, your body pulls back from expansive, intuitive awareness and locks into survival mode (no bueno). How to restore peripheral, panoramic thinking: • lower endotoxin -> raw carrot salad, mushrooms, bamboo shoots...they act like natural antiseptics; apart from that, no raw or undercooked or reheated veggies, starches, grains, and no nuts, seeds, legumes; opt for ripe fruit, juices, honey, marmalades, etc • support electrolytes -> salt and a pinch of baking soda in fruit juice protect against the hyponatremia/endotoxin loop • steady blood sugar -> fruit juice-sip every hour, ripe fruit, honey, dairy with protein keep the brain fueled and cortisol low • block stress mediators -> aspirin, sugary coffee with cream, niacinamide, bio-identical progesterone/pregnenolone and thyroid hormones all protect mitochondria and stabilise mood and are anti-endotoxin • light & warmth -> UV light, sunlight, red light and good thyroid function shift cells back into respiration, producing CO₂ instead of lactic acid • ditch PUFA (all unsaturated fats) -> seed oils / unsaturated fats intensify inflammation, suppress thyroid and worsen gut leakiness • saturated fats (coconut oil, butter, cacao/cocoa) protect the intestine, cacao/cocoa in particular is anti-endotoxin and it reduces leaky gut • gelatine / glycine / bone broth -> help shield the liver by limiting fat oxidation from seed oils and calming the inflammatory reaction to bacterial endotoxin; eat daily • activated charcoal (occasionally) binds toxins • naringenin, found most abundantly in orange marmalade (the peel) and then some citrus fruit, lowers endotoxin induced inflammation; eat marmalade daily!) • vitamin D suppresses endotoxin, supports gut barrier integrity • ginger calms the gut, lowers serotonin • aged cascara sagrada -> helps with constipation, as do magnesium citrate, coffee, adequate calories, insoluble fibre (Ray Peat carrot salad, well-cooked mushrooms, bamboo shoots), blueberries, baking soda, aspirin, B1, methylene blue, psyllium husk, thyroid, ginger • vitamin E (mixed tocopherols and tocotrienols) -> fights inflammation • taurine protects the endotoxin burdened liver (my top supp) • drugs like cyproheptadine or lisuride can be powerful serotonin antagonists • keep stress low -> simple breathing, CO₂ rich environments, whimsy, novelty, silly goose time and play, closeness with other people and restorative rest expand awareness • some safe antibiotics might sometimes be needed (minocycline most notably) to unalive bacteria that cause endotoxin overload When the gut lining is calm and metabolism is steady, your digestion is perfect, your entire cognitive field expands, awareness widens and intuition returns, and your thinking regains depth and subtlety. When you heal the gut, the mind reopens. Trust.

I'm experimenting with 5-MeO-DMT because it may be most underrated longevity molecule no one is talking about. + Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable increases in synaptic density and firing frequency in rodent models. + Proteomic reorganization: in human cerebral organoids, 5-MeO-DMT triggers rapid proteomic shifts favoring cellular reorganization and synapse formation. Early evidence of structural brain renewal at the molecular level. + Default Mode Network reset: The DMN calcifies with age locking us into rigid, repetitive patterns of thought. 5-MeO-DMT disrupts these patterns, restoring bottom up connectivity between sensory and creative brain regions. A forced return to neurological flexibility and youthfulness. + Systemic anti-inflammation: suppresses pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) while upregulating IL-10, the anti-inflammatory signal. Mediated through the Sigma-1 receptor, suggesting a mechanism distinct from other psychedelics.