Steve Rio

@5matthewdub @PhaentGames Ya, it's complicated and there were a lot of details.. I thought he did a solid job overall with harm reduction. It's like someone getting to fly an F-15 and describing the horsepower of the engines incorrectly because you don't understand jet propulsion dynamics.

@PhaentGames hope so too! he's at least modelling something like responsible use, although him flatly saying "27mg" when some was im and it wasn't clarified which was what, isn't great x.com/SteveRio/statu…

the weird thing about the bryan johnson 5meo stunt is that he already has the molecule tattooed on his body and he's larping as though it's his first time

@PaulAustin3w Appreciate you Paul!

@SteveRio I agree with this. The only reason I made it a point in my post is because Bryan has a reputation for only doing things - often too precisely - that the clinical research backs and supports.

Bryan Johnson livestreamed a 27mg dose of 5-MeO-DMT yesterday to millions of people and called it the most profound experience of his life. What almost no one in the conversation is pointing out is that 27mg is a MASSIVE dose, well beyond what the clinical research supports, and it reflects a bigger problem in how this molecule is being facilitated right now. For context, the only Phase 1 clinical trial on vaporized 5-MeO-DMT tested doses up to 18mg. Shulgin listed the upper range at 20mg. Most experienced practitioners I know consider anything above 15mg to be high. And this isn't unique to Bryan. Across the 5-MeO facilitator landscape right now, there's a widespread assumption that bigger dose equals deeper experience, that the whole point is to get someone to the white light, the full ego dissolution, the cosmic reveal. That assumption is wrong, and it's the core reason this space has a safety problem. I've worked with this molecule myself, and nothing in 12+ years of psychedelic experience prepared me for what it does to the body (not necessarily the mind...) My first time with 5, I shook so hard I lost track of where I was in the room. I was making sounds I'd never heard come out of my own mouth, heat flooding my chest, tension I didn't even know I'd been holding suddenly leaving in these full-body waves that had nothing to do with my conscious mind. That's the medicine doing its job. Not the cosmic vision nor the white light. It was all about the nervous system releasing stored-up tension from the past years, if not decades, of life. The real value of 5-MeO-DMT -- the thing that actually changes people's lives -- is what happens in the physiology. Full release. The nervous system clearing out years of stored trauma, holding patterns, and tension that live below conscious awareness. You can get there without heroic doses. You get there with precision, with a facilitator who understands what's happening physiologically and who can tell the difference between a healing release and a genuine crisis, because from the outside they look almost identical. Bryan had Dr. Robin Carhart-Harris on call and a medical team on site. Most people sitting with 5-MeO-DMT facilitators have none of that. They have someone who attended a few ceremonies and decided they were ready to hold space. If this molecule is entering the mainstream, and thanks to Bryan, it just did in a massive way, the conversation needs to move past "how far can we push it" and toward "how do we keep people safe while the real clearing happens." What's your experience been like with 5?

@PaulAustin3w I forgot to mention.. the other factor overlooked is that the IM substance m is a succinate form of 5-meo. This means that up to 35% of the material weight is succinic acid molecule.

@PaulAustin3w Hey Paul! I get your stance here and agree in theory but the math is wrong. There are a number of points people don’t understand about the protocol that Bryan was given.

This was the most profound experience of my life. I am stunned beyond comprehension. This molecule is without peer. The 27mg dose opened up what felt like pure consciousness and intelligence. A majestic reveal of existence itself. In all its incomprehensible glory and majesty. It is impossible to explain with words. Whatever you imagine, multiply it by 1,000 and then add infinite width and depth and dimensions. But entrance was not granted without prerequisite. Existence demanded that I submit. That I say yes; without attachment and without condition. Yes to existence; yes to the dissolution of self; yes to release control; yes, to all. My ego registered the ask and panicked. It wanted control. It was desperate for control. It pleaded to escape from the torrent of light and essence that threatened to rip my sanity into chards. The urge to eject was overwhelming. Terror thundered throughout my mind and body. It took everything within me to release. I overcame and was treated with bliss that defies imagination. A euphoria colored with perfect harmony of all things. An orchestra of essence washed over me and swept me up in dance. It was home. The highest aspiration of intelligent life. For some reason, stored and tucked away as the ultimate prize. A single concept emerged in omnipresence: we cannot grok the preciousness of our existence. Yet it is everything we’ve ever wanted and more. The state we long for without knowing it exists. This caused me great pain and heartache. A swell of loyalty and devotion emerged inside me, pledging allegiance to existence. To become a warrior and caretaker of life on earth. To protect at any cost the candle of consciousness that has miraculously emerged in this part of the galaxy. What awaits will wipe all your tears, soothe all your sorrows, and infinitely exceed your wants.

@PaulAustin3w Always love your voice in this space Paul. You’ve been instrumental in educating and raising awareness.

Helpful context from Steve about Bryan's dosage yesterday. Steve helped to facilitate the experience.

@PaulAustin3w I say this being someone who has administered more doses than all the clinical trials combined. I do this work with an incredible level of care and sophistication.

@PaulAustin3w 3. No one in the space is as precise as what you see in that live stream when it comes to dose measurement. No one.

@PaulAustin3w 2. The device used has a large chamber and the dose was pre-vaporized into it. You must account for loss in this process.

@PaulAustin3w 1. This is a proprietary protocol combining intramuscular with vaporized. The absorption rate curve on these two administrations is very different

Week 4 on Reta: – 16 lbs down – lifts are all up or holding steady – abs visible, insane vascularity – confidence through the roof – libido is high, having more sex than I have in years – focus and drive have never been more locked in why is everyone not on this?

round 2 is about to begin

Tomorrow I’m doing the world’s most powerful entheogen. It obliterates the self and enables raw, full-spectrum consciousnesses. What I imagine the singularity will feel like. This is a longevity experiment + exploring the future of a deeply interwoven human+AI reality.

@2cSynek 3MMC has a completely different profile than 2 and 4 in my clinical and personal experience. Yes the fiendish part is challenging. Best in facilitated environments that manage dosing appropriately. "clarity not euphoria" is a good way to describe for sure

@SteveRio Its a shame cathinones have their fiendish quality to them. Why 3MMC and not 4MMC? Is it about clarity and not getting side-tracked by euphoria?

This is a solid list but is missing 3-MMC which I’d place in A-tier

@2cSynek Because it is absolutely the best therapy-support substance for helping people communicate clearly.

@SteveRio How come?

Can’t wait 🙏🐸

This is true. @enfoldinstitute for the world’s most comprehensive 5-Meal-DMT protocol.

@Josh_0x01 @Polymarket You have that backwards

@Polymarket 5-MeO-DMT is to DMT what a strong coffee is to crack cocaine btw. He's not trying DMT

JUST IN: Anti-aging entrepreneur Bryan Johnson announces he will try DMT as a “longevity experiment.”