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tuōmo

@7uomoki

tuomo kiiskinen • md-phd • building ai-powered next gen health @Stanford • quant genomics x data sci x biomedicine

Palo Alto, CA Katılım Eylül 2022
1.6K Takip Edilen2.9K Takipçiler
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tuōmo
tuōmo@7uomoki·
Genome analysis with AI is cool i guess - but a simple CLI wasn't enough for me. Introducing HGI (Human Genome Interface): HGI connects agents to highly optimized bioinformatics tools, performing a full genome analysis in ~1 minute (!) on a MacBook Pro. It identifies both known and novel high-risk variants, all analyzed by LLMs. Compressing the pipeline from the original >60 minutes down to this timeframe was an exciting computer science and bioinformatics challenge. Thrilled with the results, as the current framework enables a genuine "talk to your genome" experience. HGI significantly boosts AI capabilities, as LLMs typically struggle with standard genetics and bioinformatics tools and tasks. Currently for research purposes only, but open for inquiries.
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tuōmo
tuōmo@7uomoki·
@JohnGolf_CA @willdepue basic routine tasks, especially physical is where their inexperience shows on the other hand
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John Silver
John Silver@JohnGolf_CA·
@7uomoki @willdepue Cross-field search is where LLMs shine already. My taste in bio though? Came from years of failed experiments. Hard to code that.
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will depue
will depue@willdepue·
good thing taste and judgement are ineffable human qualities uncapturable by a computer…. right.… right guys??
Matthew Kirshner@MattyKirsh

I know I’m not AI-pilled enough but bio is a great antithesis to this. The most remarkable bio discoveries and technologies (CRISPR as the queen bee example) come from super random cross-field serendipity that AI might be able to find but does not (yet) have the taste to really elevate and pursue without human prompting to really dig in. So much taste + intuition + judgement behind biological invention and discovery Plus step change discoveries in bio often end up being bottlenecked not by ideas + raw quantitative analytical power but by the ability to run hyper-nichy basic science experiments (which are often least amenable to lab automation leveragable by our future ai scientist overlords)

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tuōmo
tuōmo@7uomoki·
@snmzeno @willdepue yeah and it doesn't have the same natural boundaries like it is just extremely unlikely for let's say a statistical geneticist to have a problem and find out that let's say some model used in let's say volcanology is actually through first principles directly applicable here
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zeno
zeno@snmzeno·
@7uomoki @willdepue AI can hold much more context than any single individual. Seems natural that it would be able to use that to make cross field connections that we never could
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tuōmo
tuōmo@7uomoki·
@tszzl one *company* other dominating world economy is mathematically impossible as it would collapse both itself and world economy (assuming current model) -- other than a the state as the company.
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tuōmo
tuōmo@7uomoki·
@lpachter Europe strikes back against all the cheap chinese EVs!
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Lior Pachter
Lior Pachter@lpachter·
I don't understand everyone dunking on the new electric Ferrari. It's got a large trunk which is great for grocery shopping, and at $64k it's less than a Hyundai IONIQ 9 which retails for $70k
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tuōmo
tuōmo@7uomoki·
@EthanHe_42 20% energy spent there is a tradeoff for lower absolute energy spent per beneficial outcome. nutrition, survival, homeostasis maintenance, movement - intelligence (also without but especially with tools) makes all these much more efficient
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Ethan He
Ethan He@EthanHe_42·
Humans are the only species that spends 20% of their energy on the brain. Most animals are well below 10%. The brain is "useless" in the direct survival sense. It doesn't catch prey, doesn't run, doesn't fight. Spending 20% of precious calories on being smarter has to help survival. % of energy spent on brain is a good indicator of useful intelligence. % of energy spent on AI might be a good indicator of how advanced a civilization is. Currently that number is 1%.
Ethan He tweet media
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tuōmo
tuōmo@7uomoki·
@EddyVGG only X is somewhat cautious about ai generated content, in a way linkedin is the most horrific as real people post ai generated replies to ai generated content there blatantly
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EDDY V
EDDY V@EddyVGG·
i was just on facebook and the amount of alyssa liu ai generated videos is frankly just disturbing. blatantly fake yet thousands of what seems like real people believing its real (all boomers btw with pfps at the lake house 7 out of 10 times go figure). what scares me is being that disconnected one day.
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tuōmo
tuōmo@7uomoki·
In the beginning God created the heavens and the earth. Now the earth was formless and empty,darkness was over the surface of the deep, and the Spirit of God was hovering over the waters. And God said: “I do more meaningful, cutting-edge ‘research’ on the advancement of physics and biology than all the academic university labs on Earth combined. But I don’t use the pretentious, low-accountability term ‘researcher’. Engineer.”
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tuōmo
tuōmo@7uomoki·
in the future spine will be more important than brain
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tuōmo retweetledi
tuōmo
tuōmo@7uomoki·
I do more meaningful, cutting-edge “research” on the advancement of genomics and medicine than all the academic university labs on Earth combined. But I don’t use the pretentious, low-accountability term “researcher”. Engineer.
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tuōmo
tuōmo@7uomoki·
Only if your mind is limited to k2 thinking. If you think in terms of k3, it becomes obvious that stars bigger than the Sun are the most overwhelming source of energy
tuōmo tweet media
Elon Musk@elonmusk

So obvious

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tuōmo
tuōmo@7uomoki·
@willdepue although finnish folk music tradition quite interestingly has incorporated bluegrass influences like the banjo here. there is even a subgenre.. and this finnish band is famous youtu.be/e4Ao-iNPPUc?si…
YouTube video
YouTube
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tuōmo
tuōmo@7uomoki·
@Hellaorganics amazing thread! i had pokemon red on a transparent b&w gameboy pocket!
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CMO333
CMO333@Hellaorganics·
Pokémon Red & Blue are probably the most technically impressive games ever made relative to the hardware they ran on. A thread on assembly code, memory limits, and the engineering black magic that built the biggest media franchise on earth 🧵
CMO333 tweet mediaCMO333 tweet mediaCMO333 tweet media
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tuōmo
tuōmo@7uomoki·
@tszzl truth value of the statement highly conditional on their whereabouts
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tuōmo
tuōmo@7uomoki·
and no, this is not an anti-anthropic post. i used Opus as the name because it resembles swedish band Opeth and made it misanthropic cause it both is a term popularized by elon but also aligns with black metal scene misanthropic worldview! not a hater
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Keşfet

@JohnGolf_CA @willdepue @snmzeno @tszzl @lpachter @EthanHe_42 @EddyVGG @elonmusk