Ankit Mahadevia

Be humble and kind. But know your worth.

I sent ChatGPT an audio file of a series of FART sound effects and asked what it thinks of "my music" and this is what it said

It looks like the White House is finally taking US-China biotech competition seriously. The FDA is putting forward an expedited IND pathway that would shorten time to first-in-human. Overdue, but good news for American biotech.

Your morning coffee on an empty stomach is a cortisol bomb. Cortisol follows a natural rhythm. It peaks when you wake up, then gradually drops through the day. Breakfast is the signal that tells your body to start pulling cortisol back down. Skip that signal and cortisol stays elevated for hours past its normal window. Now add coffee. Caffeine directly stimulates your adrenal glands to produce more cortisol. So the actual sequence for millions of people every morning: wake up with peak cortisol, skip food, pour a stimulant into an already-stressed system, then wonder why they feel wired and anxious by 10 AM. The mechanism connecting this to depression runs through serotonin. Your brain synthesizes serotonin from tryptophan, but tryptophan needs insulin to cross the blood-brain barrier. Insulin comes from eating. No breakfast means no insulin spike, which means less tryptophan reaching the brain, which means less serotonin production during the exact hours your brain is trying to stabilize mood for the day. This study found the link is strongest in adolescents (51% higher odds of anxiety vs no significant link in adults). That tracks perfectly. Teenagers skip breakfast at the highest rate, sleep the least, and drink the most caffeine relative to body weight. Three compounding cortisol drivers stacked on a brain that's still developing its stress regulation systems. 399,550 people across 14 studies. The finding isn't that breakfast is magical. The finding is that your body uses that first meal as a hormonal reset button, and skipping it leaves your stress system running in the background all morning like an app you forgot to close.

If you’re seeing a bunch of Japanese posts, here are some fun facts: Japan has more daily active users and more time spent on X than any other country in the world. Over two thirds of the country is monthly active on X. X in Japan has one of the highest penetration rates of any social network in history.

We love the Hawks, We love the Bulls, Pick your poison with Cubs/Sox But there is NOTHING like Chicago when the Bears are playing great football.

AI should allow med schools to rethink whether 4 years is still necessary for med school. If students can focus more on clinical practice and less on memorizing the Krebs cycle and molecular bio, many programs could eliminate a year, reducing both costs and physician shortages.

You are not your grand plans. You are your daily patterns.

Too many managers reward people for the passion they show instead of the value they add. Evidence: Even when they do worse or no better than their peers, people who exude enthusiasm get more praise and promotions. What counts is not expressed emotion. It's contribution.

I think it bears repeating that BART installed tall gates to enter the subway and they're gaining $10m in revenue a year plus the need for maintenance is down by *95.7%* Passengers who were unwilling to pay a few bucks were causing 96% of the public cleanliness problems!

Very good read. If you want nuance, THIS is nuance.

The concept of working 40 hours per week for the rest of your life just to afford basic necessities is genuinely insane.