ANNU DALAL

Delighted to share this amazing collaborative study involving our laboratory @IITKanpur now published in @Nature! This was spearheaded by David Baker's lab @UWproteindesign with contributions from several labs across the globe! Link: nature.com/articles/s4158…

Great to see @gangulymoni, a superstar PhD student in our laboratory @IITKanpur, rocking his poster at the Gordon Research Conference on Ligand Recognition and Molecular Gating! #Proud#Mentor#Moment

Delighted to share our study on promiscuous chemokine-engagement by the Duffy antigen receptor, modulation by tyrosine sulfation, and impact of Fya/Fyb polymorphism! Molecular basis of promiscuous chemokine-engagement by the Duffy antigen receptor biorxiv.org/content/10.648…

Our work is recognized by the Om Prakash Bhasin Award in Biotechnology, given for excellence in Science & Technology! What an honor to be in the great company of previous awardees like A.P.J. Abdul Kalam, M.S. Swaminathan, K. Kasturirangan, & many more! All credit to the team😎!

Integrating techniques and disciplines to drive structural and chemical biology forward: Trends in Biochemical Sciences cell.com/trends/biochem…

🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n] nature.com/articles/s4158…

#JustPublished from Dr. Shashi Gupta’s lab @CSIR_CDRI in collaboration with Dr. Gaurav Ahuja’s group @IIITDelhi , in Cell Reports! EvOlf: an evolutionary-guided deep-learning framework for GPCR agonist prediction across 24 mammalian species. Read: cell.com/cell-reports/f…

What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡⁠ ⁠ A 2023 @scisignal study solved the structure of this extracellular protein that plays an essential role in vision.⁠ ⁠ In the retina, light is perceived by photoreceptor cells that transmit signals to neurons called bipolar cells, which in turn relay the signal to the retinal ganglion cells that form the optic nerve. The activation of bipolar cells by photoreceptor cells depends on the precise positioning of multiprotein complexes on the surfaces of both cell types. ⁠ ⁠ Pikachurin is an extracellular matrix protein that bridges these complexes by making contacts with the membrane protein dystroglycan on the photoreceptor cell and the receptor GPR179 on the bipolar cell, thus ensuring that photoreceptor cells are properly aligned with the bipolar cells.⁠ ⁠ Learn more: scim.ag/41dTWIP

A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor | Nature Communications nature.com/articles/s4146…

Congratulations!! Shirsha Saha for being selected for the highly competitive International Birnstiel Award for Doctoral Studies in Molecular Life Sciences carried out under mentorship of Prof. Arun Shukla imp.ac.at/achievements/b… @MehtaFF @BSBEIITK1 @IITKanpur

Thrilled to share my first PhD paper on intrinsically biased receptor CXCR7 is now live on bioRxiv🎉 This milestone would not have been possible without the constant guidance and encouragement of my mentor @arshukla. Grateful for constant support ✨ biorxiv.org/content/10.110…

Extremely thrilled to share our latest study uncovering the mechanisms behind atypical activation and dimerization of the intrinsically biased chemokine receptor CXCR7! ✨

Extremely excited to share the latest breakthrough from our lab—uncovering the mechanisms behind the atypical activation and dimerization of the intrinsically biased chemokine receptor CXCR7! A big step forward in understanding GPCR biology !

Excited to share a wonderful study from our lab presenting previously unanticipated lipid-mediated dimerisation and atypical modes of activation in CXCR7. Visit the link to dive into some cool, amazing and novel structural observations on CXCR7. biorxiv.org/content/10.110…

Thrilled to share our new study on CXCR7/ACKR3! Using cryo-EM, we reveal a unique activation mechanism for CXCR7/ACKR3, including how it serves as an atypical opioid receptor. Read the full open-access article here: biorxiv.org/content/10.110…

Delighted to share our latest work exploring the molecular underpinnings of atypical activation and dimerization in the intrinsically biased chemokine receptor CXCR7! biorxiv.org/content/10.110…

Excited 🎉to share our new study that dives deep into CXCR7/ACKR3, showing atypical activation mechanism of this receptor and its role as an atypical opiod receptor. Read the article here 👇🏻

Thrilled to share our new study revealing how lipid interactions drive unique activation and molecular glue–like dimerization in the intrinsically biased chemokine receptor CXCR7. Discover how these findings uncover new principles of GPCR regulation and signaling.

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors biorxiv.org/content/10.110… #biorxiv_biochem