Dingchang Lin

206 posts

Dingchang Lin

Dingchang Lin

@DingchangLin

Asst. Prof @JohnsHopkins; Broadly interested in neurotechnology, genetically encoded tools, and materials science.

Katılım Şubat 2020
642 Takip Edilen1.7K Takipçiler
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Dingchang Lin
Dingchang Lin@DingchangLin·
🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n] nature.com/articles/s4158…
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Dingchang Lin
Dingchang Lin@DingchangLin·
@MichaelLinLab Amazing method! I am curious how the transfection efficiency and expression level compare to plasmid transfection.
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Prof. Michael Lin
Prof. Michael Lin@MichaelLinLab·
Protein/enzyme engineering has a severe bottleneck — and it's not in AI modeling or compute time. It's in actually building and testing protein variants. Proud to introduce our latest work, MIDAS: a way to go from primers to protein assays in mammalian cells in one day. 🧵
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Sholto David
Sholto David@addictedtoigno1·
Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact ThermoFisher has systematically manipulated antibody validation data. Short Thread... 🧵
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Ali Max Erturk
Ali Max Erturk@erturklab·
Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s4158… led by @Dorie00 & @yingchen733
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Shunzhi Wang
Shunzhi Wang@wang_shunzhi·
A growing protein cage has no architect. Each piece only responds to its local environment. Yet somehow, thousands of pieces can come together to form a large, precise sphere. Today in @Nature, two back-to-back papers from our team and @UWproteindesign show how de novo protein design can make this kind of self-assembly programmable. The trick: we didn't design perfect symmetry. We designed the rules for breaking it. [1/17] rdcu.be/fjNgF nature.com/articles/s4158…
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Sholto David
Sholto David@addictedtoigno1·
Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures", but their own internal data.
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Yuanwen Jiang
Yuanwen Jiang@JiangYuanwen·
Our work introduce TopoLock, a general interfacial engineering strategy applicable to a wide library of bioelectronic materials and complex device structures, enabling reliable sensing and stimulation even in the most motion-intensive anatomical regions. nature.com/articles/s4192…
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Yuanwen Jiang
Yuanwen Jiang@JiangYuanwen·
I am delighted to share that our lab’s very first research paper was published today in @NatureElectron on chronically stable, abrasion-resistant bioelectronics.
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Katie Galloway
Katie Galloway@GallowayLabMIT·
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
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Shunzhi Wang
Shunzhi Wang@wang_shunzhi·
1/ Excited to share our new Review in @Nature: “The past, present and future of de novo protein design.” Here, we mainly focused on structure-guided protein design. The field is entering a new phase: now that we can design new proteins, what should we build next?
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Julia Bauman
Julia Bauman@JuliaBauman2·
The most beautiful molecular recorder 😍 GEMINI is a self-assembling protein system that records cellular events as physical layers, readable via imaging. Achieves down to 15 min resolution and works nicely in vivo! From @DingchangLin's lab in @Nature
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Yulong Li Lab
Yulong Li Lab@yulonglilab·
Excited to share our new paper on GRAB_PGE2-1.0, the first genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 (PGE2) dynamics in vivo! It enables real-time imaging in cultured cells, acute brain slices, and living mice.
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Denis Wirtz
Denis Wirtz@deniswirtz·
We have developed a new AI-based assay to rapidly identify new molecular targets to inhibit cancer cell migration and metastasis. See more details here: science.org/doi/10.1126/sc…
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Dingchang Lin
Dingchang Lin@DingchangLin·
🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n] nature.com/articles/s4158…
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Dingchang Lin
Dingchang Lin@DingchangLin·
@N_Rajewsky Sorry we are unable to share more details about our ongoing research in this open channel. But we are willing to share offline if you are interested.
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Dingchang Lin
Dingchang Lin@DingchangLin·
@N_Rajewsky e.g. we are currently using GEMINI to study signaling dynamics in tumors w/wo drug treatment
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Nikolaus Rajewsky
Nikolaus Rajewsky@N_Rajewsky·
@DingchangLin would be good to understand the “fundamental understandings” a bit better-thank you.
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Dingchang Lin
Dingchang Lin@DingchangLin·
@N_Rajewsky Push the technology to broader applications (recording more different stuffs and being used beyond our lab) and also to advance fundamental understandings.
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Nikolaus Rajewsky
Nikolaus Rajewsky@N_Rajewsky·
@DingchangLin what do you mean by “push this technology”- to push your paper or to understand something? thank you.
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Patrick Hsu
Patrick Hsu@pdhsu·
Computationally designed “tree rings” for recording cellular history 🤯 I love synthetic biology inspired by mother nature’s tricks. Congrats to the authors
Dingchang Lin@DingchangLin

🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n] nature.com/articles/s4158…

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Keşfet

@MichaelLinLab @Nature @Dorie00 @yingchen733 @UWproteindesign @JHUBME @kalhorlab @JohnsHopkins