Adam
567 posts
@Adam1996Indep @IShadowLI He’s already been elected & inaugurated. We’re past activism as far as that goes.
I’m directly addressing your incessant whining, but sure that makes *me* “pathetic” I guess, lol
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The Muslim mayor of the largest city in America (which a buncha people said he would try to bring Sharia law to) wished Christians well on a Christian holiday, and a buncha evangelicals are congregating in his replies to correct & quiz him.
An insufferable way of living.
Mayor Zohran Kwame Mamdani@NYCMayor
Today, on Good Friday, we mark a day of sacrifice. Some New Yorkers will abstain from eating; others will spend hours without speaking. Faith, the Bible tells us, is belief in the things unseen. That belief is what will guide so many of our neighbors in solemn reflection and reverence. I wish all those observing Good Friday a blessed day of peace.
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@Adam1996Indep @PastorTrey05 @IShadowLI A man who observes a different religion from you expressed good wishes on one of your holiest days and that's just like beating up your mom?
This nonsense is just beyond belief.
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@PastorTrey05 @IShadowLI Addressing some threats physically is indeed something you would do. Voting against an obvious threat to your values and speaking against those threats are hardly unchristian. Christians often mistake “doing nothing while bad people do bad things” for Christlike virtue. Pathetic
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@Adam1996Indep @IShadowLI lol, whichever reason you need to put in your ledger for me not playing your reindeer games is fine with me.
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@dkegel @NightShiftMD I think we define “significant health risks” differently. Measles cycled through annually pre-1963.
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@Adam1996Indep @NightShiftMD Taking measles as an example, we'd like to prevent outbreaks, because measles carries significant health risks. For that, ~95% of people need to be vaccinated. So if roughly 5% of people skip it, that's fine.
But arguing that people should get measles is just insane.
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To the "clot" shot morons. Please turn off your idiotic X feeds and leave medicine to the professionals. Stop your ad hominem wild accusations about being bought by Pharma. If you don't want vaccinations, fine. But stop impuning the reputations of people and science you know nothing about. You long since grown boring and tiresome.
Massimo@Rainmaker1973
Study shows COVID vaccines decreased heart attacks and strokes. A sweeping analysis of nearly 46 million adult health records has delivered a clear verdict: COVID-19 vaccination sharply lowers the risk of heart attacks and strokes, directly refuting persistent claims to the contrary. Published in Nature Communications, the study followed people across England from December 2020 through January 2022. It documented a 10% drop in serious arterial blood clots (including heart attacks and strokes) after the first dose alone. Protection strengthened further with subsequent doses: a 20% reduction among those fully vaccinated with Pfizer/BioNTech and a striking 27% reduction for AstraZeneca recipients. The researchers were upfront about rare side effects—myocarditis and certain clotting disorders—that can occur shortly after vaccination, but stressed these remain exceptionally uncommon. By comparison, catching COVID-19 itself dramatically raised the odds of major cardiovascular events. Lead co-author Dr. Samantha Ip described the results as some of the strongest evidence yet that the vaccines do more than prevent severe infection: they also confer lasting protection against two of the world’s leading killers. [Ip, S., North, TL., Torabi, F. et al. Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million adults in England. Nat Commun 15, 6085 (2024). doi. org /10.1038/s41467-024-49634-x]
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@ronnoc_rd @sjs856 That’s legit impressive to have an intervention perform so well. Agreed on sample size. I’m far from an expert or even a knowledgeable amateur; my goal was to ensure my kids didn’t come across autoimmunity unnecessarily
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@Adam1996Indep @sjs856 Becomes more complex with things like influenza.
Do we compare to placebo or compare to last seasons vaccine?
Extremely tricky. I had a study stopped early once for super-superiority against the comparator which was heartening, but the numbers required to demonstrate are big
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False.
Placebo in a clinical trial = standard of care or other agent that differs from what is being trialed as long as it makes sense
Your “true placebo” fallacy is just an excuse for Tuskegee 2.0 which RFK Jr. approved funding for in Africa on Black babies
Steve Kirsch@stkirsch
@sjs856 placebo= saline which is the only true "placebo"
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Adam retweetledi
Good Friday marks the conquest of death on the Cross by Christ, who is not a generality but a man and also God.
Mayor Zohran Kwame Mamdani@NYCMayor
Today, on Good Friday, we mark a day of sacrifice. Some New Yorkers will abstain from eating; others will spend hours without speaking. Faith, the Bible tells us, is belief in the things unseen. That belief is what will guide so many of our neighbors in solemn reflection and reverence. I wish all those observing Good Friday a blessed day of peace.
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@ronnoc_rd @sjs856 Fair questions. In a perfect world, yes. In the world we have, I’m open to the argument that SOC is necessary as a placebo depending on the target. With childhood illnesses and the surge of autoimmunity, I’d like some skepticism around vaccines vs. dogma.
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@Adam1996Indep @sjs856 What about blood pressure meds?
What about vaccines with a potentially better safety profile?
Cholesterol tabs?
You want SOC withdrawn for these studies?
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@ronnoc_rd @sjs856 You’re correct. I think that should be standard regardless of previous vaccines. That said, if something like plague was circulating and a death rate of 33% was guaranteed, I’d take a vaccine in all likelihood.
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@Adam1996Indep @sjs856 The Covid vaccine studies were true placebo controlled, as we had nothing else. I know this because I was a patient on the NovaVax study as I was worried I was going to die due to my job on ICU at the time.
My treatment allocation when the study finished? 0.9% NaCl
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@ronnoc_rd @sjs856 If you’re testing a traditional vaccine for a childhood illness with high survival rate, a randomized study with inert placebo is not an ethical issues especially since supportive care is available
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@Adam1996Indep @sjs856 So you want me to recruit 15,000 patients for a study and take half of them off their existing medications? Therefore deliberately inflicting harm?
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@PastorTrey05 @IShadowLI No. You’re avoiding the practical hypothetical because you know your position is silly.
Would you stop an attacker in public? Would you physically take down an active shooter at a school? Would you physically restrain a bully going after your kid? If not why not?
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@Adam1996Indep @IShadowLI Oh, I get it, we’re makin silly hypotheticals to justify the silly stuff you’re doin in real life.
Pass.
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@PastorTrey05 @IShadowLI Would you stop someone from attacking your mom or would you sit back and let it happen? Assuming you’d step in and stop it, why would you do that as a Christian?
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@Adam1996Indep @IShadowLI What on earth are you even talkin about?
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@PastorTrey05 @IShadowLI I mean, standing idly by while there are avenues to peacefully remove openly hostile people from office seems pretty anti-Christian to me. Being a Christian doesn’t mean allowing wrong when you have means to stop it. Would you “turn the other cheek” if someone attacked your mom?
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@IShadowLI @Adam1996Indep I get why you believe that.
It’s because you are both ignorant and disrespectful of other religions, and so you assume that everyone else feels the same toward you.
A little bit of introspection could clear up a lot of your umbrage.
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@Jason___YYC @r0b0t_sp1der Maybe people want to see actual value for forking their money over to govt?
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@SenateGOP You’re still worthless until you do more than tweet. Pathetic. The coming losses in November are on R Senate “leadership”.
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Birthright citizenship for illegal aliens isn’t compassion—it’s a national security loophole.
President Trump is closing it. Democrats are fighting to keep it wide open.
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@TheReelRandom Same playbook every time from your side. Cant make any counterclaims so you go after their credentials to take them off the field. Do Dr. Peter McCoullough next.
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Not sure where Dr. Wolf went to med school but I don’t think it’s accredited.
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@thescottbarber There’s aggression everywhere. People get mad when they feel threatened.
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This, in a nutshell, captures the Christlessness of the MAGA
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@AscendingBio Totally fair. Hope no more FDA warnings headed to $IBRX. The studies must be done.
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$IBRX Reflections on IL-15 and Sepsis Post
I have seen many comments about Dr. Patrick's Sepsis study post this week. Most conclude that this 2010 study is sufficient evidence for the FDA to immediately approve Anktiva for the treatment of Sepsis.
The study cited here by Dr. Patrick concerning IL-15 and sepsis is a mouse study. The human immune system is different than that of mice. Also, these mice are not getting sepsis in a natural way, it is a manipulation. So, there have been countless times that something looks like a cure in mouse models, but it does not work in humans. In fact, that is probably the typical outcome with disorders that have a complex component.
So, that is why the next step is to test Il-15 in humans with sepsis. You start with low doses and small numbers. You build off of that if you see signs of success. These are really sick people with seriously impaired vital organs. There is a potential for unintended consequences. I think the chances of IL-15 helping is good, but there are no guarantees.
If it does work, you still need to figure out the optimal dose. Do you give one big dose immediately or multiple smaller doses? If there are common side effects, you need to figure out the best ways to treat them when they occur.
(We should not presume that the same dose and dosing schedule applies to treatment of sepsis as is used in the currently approved combo therapy for NMI bladder cancer.)
If the phase 1 study goes well, it will need to be followed by a study with a control group. That design is required to answer key questions about effectiveness and side effects.
pmc.ncbi.nlm.nih.gov/articles/PMC29…
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