Ade Adamson, MD MPP

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Ade Adamson, MD MPP

Ade Adamson, MD MPP

@AdeAdamson

Dermatologist | Health Services Researcher | Alum: @Morehouse @HarvardMed @MIT_HST @Kennedy_School | A naive EBM aficionado| Cancer researcher | Melanoma expert

Austin, TX Katılım Mart 2015
895 Takip Edilen7.7K Takipçiler
Ade Adamson, MD MPP retweetledi
Healio Dermatology
Healio Dermatology@HealioDerm·
📈 The rising number of dermatology-specific advanced practice clinicians is associated with a growing share of dermatology drug spending, specifically in specialty medications. 🗣️ @AdeAdamson discussed with @GoHealio what this means. @JAMADerm vist.ly/4nnw8
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Ade Adamson, MD MPP retweetledi
Timothée Olivier, MD
Timothée Olivier, MD@Timothee_MD·
If we talk about mortality, even with the increasing mortality rate for colorectal cancer, this cannot realistically be "felt" in clinic, the rise is impossible to be clinically "detectable" by a single physician. (see screenshot: colorectal : from 2.7 to 3.1/100 000/y over 30 years) When it comes to incidence and diagnoses, things are more complex. That's why we need works like the one published in @JAMAInternalMed, based on facts and numbers. @AdeAdamson and colleagues provided a balanced analysis which is often lacking in that space. Actually, I think their work is highly needed to be able to identify and focus on cancers where an actual increase in mortality is seen. See the nice discussion with @AdeAdamson here : theoncologyshot.com/p/are-fears-of…
Timothée Olivier, MD tweet media
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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@GIMedOnc You are correct data tell the story and this is a 30 year story/trend we describe. Not sure how 5 years more will alter the trend unless something about diagnostic scrutiny decreases or a remarkable therapy is developed. See you then.
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Nicholas Hornstein
Nicholas Hornstein@GIMedOnc·
Data tell the story, and none of us can predict with certainty where cancer incidence will go over the next decade. That said, I’ll save this in my folder of “probably wrong hot takes” and revisit it in five years (while working every day to to improve outcomes for these patients and help figure out a way to prevent this disease).
Ade Adamson, MD MPP@AdeAdamson

Searching for biologic causes for this epidemic is certainly going to be fruitless at best for most cancers, and at worst find some spurious association that needlessly scares the public.

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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@HannahRAbrams @AnilMakam "yet" is doing a lot of work here. Our study was over 30 years. How long of a latent period do you need to be convinced?! But as stated before, we don't know which ones progress, so we treat them all. More diagnostic scrutiny just makes this problem worse.
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Hannah Abrams, MD
Hannah Abrams, MD@HannahRAbrams·
@AnilMakam @AdeAdamson Thanks for this - I guess we are coming to the same point, which is that there is a subset of aggressive, rapidly life threatening ca & another intercepted earlier where we don't necessarily know effect on mortality yet, and may never bc tx w/ curative intent, often successfully.
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Anil Makam
Anil Makam@AnilMakam·
great thread by @HannahRAbrams! some thoughts story is figure 2, not figure 1 which is a smoothie of 8 cancers common feature, different than illnesses defined by symptoms, is that some grow/spread->illness & death, but others are "cancer" by pathology & regress/slowly grow
Hannah Abrams, MD@HannahRAbrams

@AnilMakam I really respect your thoughts and certainly agree some cancers are over-diagnosed. This paper & the response to it are a bit puzzling. They aggregate 8 cancers, chosen by relative⬆️incidence, rather than absolute. This ends up combining/comparing entities w/ diff explanations.

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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@AnilMakam @HannahRAbrams To add to this point we also don’t know whose individual lives are saved by screening either. All of this is a population effect. Hence the need to adjudicate this using a clinical trial.
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Anil Makam
Anil Makam@AnilMakam·
@HannahRAbrams @AdeAdamson the population data cannot be applied to any given patient how would/could you know? unless we have better biomarkers/genetics that differentiate natural history
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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@HannahRAbrams @AnilMakam The narrative is so far from “cancer is fake” right now. The pendulum is completely swung towards all of this is real and we need to find some environment toxin. We need to have a 4 day international conference and change screening guidelines. That’s where we are currently.
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Hannah Abrams, MD
Hannah Abrams, MD@HannahRAbrams·
@AnilMakam @AdeAdamson This does make sense. This is a cohort from MSK, I should say so a group that may have had more access to f/u of sx. I think another big part of the desire to make sure the narrative doesn't become "AYA cancer is fake" is having seen many EOCRC pts blown off & dx late.
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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@AnilMakam @NiuSanford As @AnilMakam states. Both can be true. And you keep bringing up screening but that not the full story because most of these cancers aren’t screened for in this population. But there is a push that we should!
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Anil Makam
Anil Makam@AnilMakam·
@NiuSanford why can't both be true? rise in real early onset CRC and also a rise in detected CRCs that are slow growing seems like the mixed story best fits the population data
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Dr. Nina Niu Sanford
Dr. Nina Niu Sanford@NiuSanford·
1. I did read the paper. Appreciate the inclusion of disease-specific nuances, however the conclusion (both in paper & post from journal account below) lumps it all together. Hence, I posted (in Sept) to clarify. 1/3
Dr. Nina Niu Sanford tweet media
Ade Adamson, MD MPP@AdeAdamson

@NiuSanford @UGrewalMD EQUALLY harmful is the narrative that there is an epidemic of early onset cancer. It distorts the entire picture. We deal with these cancers as a group and individually in the paper. Again, did you read it?

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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@NiuSanford Lumping them all together is the dominant narrative and precisely the one we are pushing back against. So we are basically saying the same thing. However, screening people under 50 certainly drives some of the increased detection. We can debate how much.
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Dr. Nina Niu Sanford
Dr. Nina Niu Sanford@NiuSanford·
3. IMO screening-driven overdx & coding/misclassification artifacts are fundamentally different phenomena (even if both increase incidence). Grouping them together obscures true disease signals. For EOCRC, rising mortality becomes rhetorically minimized as “diagnostic noise.”
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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@AnilMakam We published this paper 3 months ago. Docs read the NYTimes more than they read actual papers. It’s clear that many critics on Twitter still haven’t read the paper.
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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@AnilMakam Your thread is exactly correct. I got nothing to add as it would just be repeating what you said. lol.
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Ade Adamson, MD MPP retweetledi
Anil Makam
Anil Makam@AnilMakam·
This is one of the hardest concepts for people to understand, from patients to doctors to scientists to biotech industry
Ash Paul@pash22

Why Some Drs like @AdeAdamson & @vrpatel97 Say There Are Cancers That Shouldn’t Be Treated: Statistics show a clear spike in eight cancers in younger people, but that has brought a debate over whether many cases ever needed to be found. nytimes.com/2025/12/08/hea… via @ginakolata

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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@NiuSanford @UGrewalMD EQUALLY harmful is the narrative that there is an epidemic of early onset cancer. It distorts the entire picture. We deal with these cancers as a group and individually in the paper. Again, did you read it?
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Dr. Nina Niu Sanford
Dr. Nina Niu Sanford@NiuSanford·
Don’t think @UGrewalMD disputes importance of mortality trends. But grouping EOCRC w “overdiagnosis” cancers, despite rising mortality, risks harm. NET/appendix reclassification don’t explain aggressive EOCRC we see, & there’s no plausible screening overdiagnosis mechanism.
Ade Adamson, MD MPP@AdeAdamson

@UGrewalMD @NiuSanford @vrpatel97 Papers like ours actually give a more full picture by focusing on both incidence AND mortality. It’s unfortunate that you don’t seem to think understanding trends in cancer mortality is important.

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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@TotalCytopath @UGrewalMD @NiuSanford @vrpatel97 Our study came out 3 months ago, and the only reason folks are mad is because it got covered in the NYTimes. They offer no specific data driven critique, they are just complaining because the data doesn't fit their world view.
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Ade Adamson, MD MPP
Ade Adamson, MD MPP@AdeAdamson·
@UGrewalMD @NiuSanford Did you read the paper @NiuSanford or just the NYTimes article? We don't say anything about screening being the cause. We don't routinely screen the EO population. Its likely incidental findings from more imaging/test. NETs certainly are part of the trend.
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Udhayvir Grewal
Udhayvir Grewal@UGrewalMD·
@NiuSanford Totally agree here and couldn’t have said it better myself 🙏🏽 We need to do better both at scrutinizing these analyses before they get published and then calling out inflated conclusions/takeaways that carry the potential to harm patients.
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Ade Adamson, MD MPP retweetledi
Ash Paul
Ash Paul@pash22·
Why Some Drs like @AdeAdamson & @vrpatel97 Say There Are Cancers That Shouldn’t Be Treated: Statistics show a clear spike in eight cancers in younger people, but that has brought a debate over whether many cases ever needed to be found. nytimes.com/2025/12/08/hea… via @ginakolata
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Keşfet

@GoHealio @JAMADerm @JAMAInternalMed @GIMedOnc @HannahRAbrams @AnilMakam @NiuSanford @elonmusk