DECOD-Ag

39 posts

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DECOD-Ag

DECOD-Ag

@AgDecod

A new path towards developing effective anticancer therapies, DECOD-Ag is a @EU_H2020 project working towards a transformative immunogenicity profiling platform

Katılım Ağustos 2021
58 Takip Edilen42 Takipçiler
DECOD-Ag
DECOD-Ag@AgDecod·
The Crick component of DECOD-Ag (led by @CharlesSwanton) is based on TracerX, and so we will have the opportunity to map neoantigens in this landmark cohort. #TracerX #neoantigens
Cancer Research UK@CR_UK

Dive into the data behind the landmark #TRACERx study 🔍 📅 Nine years of research 👥 800+ patients ️🧑‍🔬 250 investigators 🏥 13 hospital sites. Read more about the study and what it means for future lung cancer patients: cruk.ink/3KtCCHv @TheCrick @UCL

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DECOD-Ag
DECOD-Ag@AgDecod·
- Coupled with their previous work, a system now exists that enables simultaneous antigen discovery for both CD4+ and CD8+ T cells
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DECOD-Ag
DECOD-Ag@AgDecod·
- In coupling this with scRNA-seq, the platform allows deep profiling of all cells bearing the TCR irrespective of their functional state - The system is compatible with several post-translational modifications of epitopes
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DECOD-Ag
DECOD-Ag@AgDecod·
This paper elegantly demonstrates the value of pairing 1000s-10,000s epitopes with their TCRs, thus enabling the characterisation of antigen-specific T (CD4) cells. biorxiv.org/content/10.110…
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