Quezada Lab

Congrats to Aurélien Marabelle’s team — intratumoural anti-CTLA-4 links Treg reduction with FcγR⁺ myeloid context, underscoring the FcγR landscape as a key determinant of CPI activity and translation. nature.com/articles/s4158…

Congratulations to @CharlesSwanton, Mariam Jamal-Hanjani and colleagues on their fascinating analysis of the evolution of lung cancer metastasis published in @Nature! nature.com/articles/s4158…

Thrilled to see a new paper led by the outstanding @Brown_lab1, now out in Nature Biotechnology. We provide mechanistic insights into how mRNA vaccines work. challenging key assumptions and offering new ways to control vaccine activity. (1/3) Read here: nature.com/articles/s4158…

Congrats to PICI researcher Dr. Catherine Wu of @DanaFarber on being part of the @CancerGrand ILLUMINE team, awarded $25M to explore the cancer dark proteome, research that could uncover entirely new targets for cancer treatment. bit.ly/4d1AxSV

Excited to share our new work uncovering a previously unknown mechanism identifying ANKIB1 as the E3 ligase that writes a critical new letter of the ubiquitin code central for immune signalling: K11-linked ubiquitin nature.com/articles/s4155…

Come join our team!! linkedin.com/posts/quezada-…

Huge thanks to the team at UCLH and the UCL Cancer Institute @ucl @uclh @uclcancer, particularly Elise Reese @ekvrees and Louise Ainley, and my mentors Benny Chain @BennyChain, Sergio Quezada @QuezadaLab and Kwee Yong.

Immunology takes center stage again at the #NobelPrize! Congratulations to Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi for uncovering how regulatory T cells maintain immune tolerance—a discovery that transformed our understanding of autoimmunity and cancer immunotherapy

Are you looking for a Clinical Research Training Fellowship? Do you want join our team working in cancer immunology and immunotherapy? Check this great opportunity from @CRUKCOLcentre colcc.ac.uk/clinical-resea…  and contact our team to discuss our proposed project

Pleased to share our preprint describing a central role for post-transcriptional processes in the response to cancer immunotherapy. Huge amount of work led by Maria Vila de Mucha and @julia_hlond in collaboration with @QuezadaLab and @MartT_babraham 1/8 biorxiv.org/content/10.110…

🧬 Join us Friday 19th Sept for CART Autoimmunity Symposium in Central London 🧬 Guest speakers from Erlangen & Hamburg on latest developments in Lupus, Multiple Sclerosis, & MG. Register in link below & see you there! ⁦⁦@uclh⁩ ⁦@uclcancer⁩ hartleytaylor.co.uk/carm-home/

@Chrystal_Paulos What is the true activity of each of the many subsets of myeloid cells in tumours and can they be coordinated towards a single (tumour-targeting) activity?

What is the most important unanswered questions to address in the field of cancer immunotherapy?

Depletion of Tregs with a non-IL-2-blocking anti-CD25  enhanced antitumor responses in brain tumors and synergized with anti-PD-1 or a tumor antigen-targeted antibody bit.ly/44nab9T  @uclcancer  @QuezadaLab #Immunotherapy

CHIP is a common, age-related condition where mutated blood stem cells expand without causing blood disorders. CHIP raises the risk of hematological malignancies, chronic inflammatory diseases (like heart & lung disease), & lung cancer. This manuscript shows that CHIP somatic clones in blood—especially TET2 mutant ones—migrate into tumors, reshape immunity, drive progression, and promote recurrence. The ability of a somatic clonal expansion in the hematopoietic compartment, to regulate malignant progression in another tissue represents a new perspective in cancer biology. #CHIP #LCMS #cancer #biology #AACR25 nejm.org/doi/full/10.10…

Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies: cell.com/immunity/fullt… Amazing collaboration led by @CR_UK funded @QuezadaLab @galvez_cancino @uclcancer and colleagues!

@CancerGrand @CharlesSwanton Congratulations!!!!

A big congratulations to #CancerGrandChallenges Scientific Committee member, Karen Vousden, who received the AACR-G.H.A. Clowes Award for Outstanding Basic Cancer Research 👇 aacr.org/about-the-aacr…

This is exactly right. Gutting the NIH will lead to a rapid labor shortage and all these jobs going overseas

Many congratulations ⁦@FAndreMD⁩ ⁦@cncurtis⁩ on the Susan G Komen awards - a great recognition for all your discoveries So well deserved

Happy Post Doc Appreciation Week! Our facilities are used by Post Docs at @uclcancer, @kingsmedicine, @QMBCI and @TheCrick. We spoke to Alex Simpson in @QuezadaLab at @uclcancer about life as a Post Doc. linkedin.com/feed/update/ur… #CelebratePostDocs

Enjoying the British summer with the tremendous team from ⁦@QuezadaLab⁩.