Prateek

It’s high time we started talking about the lack of pleasure for women in most heterosexual marriages.

1000 LiverDocs will come and go we still won't stop winning

Vitamin D is not just a bone nutrient. It has a nuclear receptor physically present inside the dopamine-producing neurons of the human substantia nigra. When activated, it controls three gene targets that determine how much dopamine those neurons produce and how long they survive. Cui et al. (2013, Neuroscience) confirmed this directly using immunohistochemistry in both human and rat brain tissue. The vitamin D receptor (VDR) is located in the nucleus of tyrosine hydroxylase-positive neurons, the cells that synthesize dopamine, in the substantia nigra. This is the brain region that degenerates in Parkinson's disease. In the developing rat brain, VDR expression emerges between embryonic day 12 and 15, the exact window when the majority of midbrain dopamine neurons are born. What happens when vitamin D activates VDR in these neurons has been mapped across multiple studies. In SH-SY5Y neuroblastoma cells overexpressing VDR, Cui et al. (2015, Neuroscience) showed that 1,25-dihydroxyvitamin D3 significantly increased tyrosine hydroxylase expression, the rate-limiting enzyme in dopamine synthesis. TH-positive cell count more than doubled compared to controls. The effect was dose- and time-dependent. Dopamine production increased. The immature neuronal marker NEUROG2 decreased, indicating the cells were being pushed toward a mature dopaminergic phenotype rather than remaining undifferentiated. Pertile et al. (2023, J Neurochem) extended this work, showing that vitamin D increased neurite outgrowth, neurite branching, and the number and distribution of presynaptic protein puncta in dopaminergic cells. They also demonstrated increased functional dopamine release. The neurons were not just producing more dopamine. They were building longer processes, forming more synaptic connections, and redistributing their release machinery outward along those processes. The survival pathway is equally significant. Vitamin D upregulates glial-derived neurotrophic factor (GDNF), which is the primary survival signal for dopamine neurons. Pertile et al. (2018, FASEB J) showed that VDR directly binds the promoter of C-Ret, the GDNF receptor, using chromatin immunoprecipitation. This is not indirect signaling. It is direct genomic regulation of the receptor that keeps dopamine neurons alive. When GDNF synthesis is chemically blocked, vitamin D's effect on dopamine neuron number disappears, confirming that the GDNF pathway is essential to the mechanism. In rodent models, developmental vitamin D deficiency reduces expression of dopamine specification factors Nurr1 and p57kip2 in the mesencephalon, decreases TH expression in the embryonic brain, reduces dopamine turnover, and alters dopamine transporter density and binding affinity in the adult brain. These changes persist into adulthood even after vitamin D status is corrected postnatally. The Parkinson's disease connection is observational but consistent. Vitamin D deficiency prevalence is significantly higher in Parkinson's cohorts. In 6-OHDA lesioned rats (a standard Parkinson's model), vitamin D administration partially restores TH expression and TH-immunoreactive fibers in the substantia nigra and striatum while increasing GDNF protein. The honest gap: this is almost entirely preclinical evidence. VDR presence in human dopamine neurons is confirmed. The downstream gene regulation, the dopamine production increases, the survival signaling, all of this is from cell culture and rodent models. No human randomized controlled trial has tested whether correcting vitamin D deficiency improves dopamine function, Parkinson's outcomes, or any dopamine-related clinical endpoint. The mechanism is well-characterized. The translation to human clinical outcomes has not been done. Cui et al., Neuroscience, 2013 Cui et al., Neuroscience, 2015 Pertile et al., FASEB J, 2018 Pertile et al., J Neurochem, 2023

I married a man who is : -was virgin -5’8 height -then earned less than 2 lakhs - never tells me where he’s going(always informs later) - knows cooking bt doesnt cook - doesnt get along with my mom at all! I’m still happy 😅

Fan costs 2k, and iron grill costs 5k. Anyway, students' lives are important first.

les langues natales changent littéralement la connectivité de notre cerveau et donc notre vision sur le monde

Nobody talks about what happens after selection… 🚨 🥹 A poor student from Hindi medium cracks an IIT through reservation. People call it “easy entry.” But inside? Classes in English he barely understands. No support system. Constant pressure. Isolation. He tries. He struggles. He breaks. One day, he calls home “Take me back… or I won’t survive.” This is the reality many don’t want to see. Reservation may open the door, but the system inside still isn’t built for everyone. This isn’t about merit this is about survival.

A shocking incident has come to light from Chhindwara, Madhya Pradesh. In a beautifully decorated wedding mandap, the bride stunned everyone by putting the garland around her lover’s neck instead of the groom in front of all the guests. Moments later, she fled from the stage during the varmala ceremony. The incident shattered the groom and his family’s dreams, and the wedding procession had to return empty-handed.

“In some PG accommodations in Noida, it’s not really about studies… it feels more like a full-on hookup culture!” “Students and working professionals all live together, during the day, everyone plays ‘decent,’ walking out with bags on their shoulders, girls neatly adjusting their dupattas, appearing all proper and composed.” “On the door, there’s a strict notice, ‘No entry after 11 PM, boys and girls are not allowed in each other’s rooms.’” “But as soon as the clock hits 11:30… the entire scene flips.” “Doors quietly open, rooms get exchanged, and suddenly, the PG starts looking more like a live-in setup.” “This becomes a daily routine, and families back home have no idea what’s really going on.” “Whether students or working individuals, there seems to be no hesitation, no fear.” “Everyone thinks the same, ‘No one will find out, might as well experience life before marriage… just enjoy!’” “And the PG owner? He knows everything… but as long as the rent keeps coming, he stays silent.” “Morning arrives, and the same act begins again…” “On calls with family, it’s all, ‘Yes mom, the environment here for studies/job is really good.’” “And the moment the call ends… laughter fills the room.” “This is the reality of a double life, one for the family as the ‘ideal child,’ and another in the nights of PG life in Noida.”

So this is the skin care routine I’ve prepared for me, idk if it’s perfect or if I will get the desired results, but I’m planning to stick to this routine and keep you guyz updated! Any tips or advice? before I start this journey??