Aldo Compagnoni

@HRH_Ted It would be fascinating if there were an alternative explanation. Any thoughts?

The key words here Stephan, are 'resulted in', or any other similar cause and effect claim. So its actually yourself who is impressively wrong.

@cremieuxrecueil I find it funny you will necessarily need analysts to determine if it works.

I'm curious if these products work, and if they do, when they can be used to start displacing analysts. Anyone tried this stuff out?

@ScottAppliedSci If it's based on CICO, then it works, by definition. It's also not complex, given that if cutting calories does not work initially, cutting a bit more will eventually work. What's complex is not suffering unduly under a calorie deficit.

Eat less and move more never works! It's based on CICO, which all the best diet gurus decry. Thermodynamics doesn't apply to open systems. Calories are imaginary heat units. It's mass balance. It's hormones. It's complex. Let's have a discovery call. You can't help yourself. Try my koolaid. Vs. Reality. 👇

@DKThomp who are the nutrition experts who claimed CICO is not the main factor in weight gain/loss, when there are consensus statements (e.g. Endocrine society) stating that it is? Plus, that "probably" in the sentence is illogical.

I'm happy to be corrected by nutrition experts, but I *really* don't like this framing in the NYT on why "calories in/calories out" is overrated. The passage below makes it seem like ultra-processed foods are bad for you in ways that have very little to do with calorie consumption. But Kevin Hall’s famous 2019 metabolic ward study found that people randomized to an ultra-processed diet ate more calories. The name of Hall 2019 paper is, literally: "Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain." In other words, if we really want to understand why *some* ultra-processed foods are bad for us—and they're not all that bad! sugar-free almond milk is an ultra-processed food!—we can't throw out the "calories in/calories out" model. One of the key ways that UFPs cause weight gain is that their energy density/rapid digestion leads to MORE CALORIES IN.

I keep coming back to this 2022 study after years - quite lovely! "Number of growth days and not length of the growth period determines radial stem growth of temperate trees" onlinelibrary.wiley.com/doi/10.1111/el…

@DeShindig Pensavo di essere scemo a notare tutte queste assurdita' provenira dell'Istituto "Liberale".

Solo questo fantomatico Istituto Liberale poteva affermare che BS è stato un liberale

@ScottAppliedSci 1. A single epidemiological study on Norwegians might be a bit too little, especially considering that the RCT were very short term. 2. Some of us have already diligently self-experimented, with zero effects during months-long n-1 trials.

☕Your morning coffee is health healthy, right? Antioxidants, polyphenols, magnesium, B-vits, even the caffeine. But the most important part is not in the beans. And it changes everything. It's the filter! I'll explain ... 🧵

@gregmushen But since collagen is more expensive than whey, you can bet the former is just a minor component added for marketing.

So in practical terms: you can’t count on this drink to give either robust muscle anabolism or connective tissue support without both (1) whey dominance and (2) vitamin C co ingestion.

I’ve seen a lot of people posting on this drink. But is it helping your gains or inhibiting them? Let’s dig in 🧵

@Tiziana0219 @micheleboldrin Dai pero', stai parlando di strategie di comunicazione, non di politica. Che le pensioni non fossero sostenibili si sapeva decenni fa, e i tuoi contribuenti hanno continuato a votare DC e FI. Non ti si puo' neanche prendere sul serio.

@micheleboldrin non è colpa del lavoratore. Che chi ha versato oltre 40 anni sia additato come "peso" sulle nuove generazioni o come parassita che non lo merita grida vendetta! Lei dia pure le sue lezioni a St Louis, io non ne ho bisogno.

Studia il passato, Tiziana. Ma studialo davvero, non proclamarlo solamente. Se vuoi lo facciamo assieme e scopriamo come siano stati "dilapidati" [!] i mitici fondi dell'INPS. Sei pronta?

@DrNadolsky I am not sure you guys talked about this in a podcast? Some guidelines read to me as "get you ldl below 60mg/dl asap, with meds if needed". If I say this to my doc he will laugh in my face. Do you have any opinions on this?

I want my LDL cholesterol nice and low 🤷‍♂️

@cremieuxrecueil If anything, there could be a negative correlation between sport performance and success dieting: many athletes struggle with caloric deficits induced by exercise. That subpopulation will have zero experience inducing a caloric deficit mostly through diet.

This conclusion is so wild. GLP-1RAs are not magic. You still lose weight through eating less, and that's it. They aren't a metabolism enhancer. So, yes, even Serena Williams overeats.

@BioLayne @RobertLustigMD Looks like he's projecting a little tiny bit.

You want to “dissemble me limb from limb” @RobertLustigMD ? Don’t threaten me with a good time 🤣 Also, I think the word you are looking for is ‘disassemble’ 🤣 Let’s see why Robert is so mad… (thread)

@FPanunzi non capisco la battuta - i prezzi in Italia riflettono la corsa al degrado del prodotto finale che si e' riscontrata nella cosidetta "first wave of coffee" negli USA nel dopoguerra e prima del dopoguerra. Uno specialty a 2.5 e' un affare.

Sono contento di non avergli mai dato nemmeno un €.

@davidhanley72 @sguyenet I don't know why anybody would consider DOGE's "research" reputable after they failed so miserably. You are functionally a troll, so no need for me to waste any more time on you.

@AldoCompagnoni @sguyenet Well sure. You are trying to substitute your anecdotes for doge’s research.

"Despite [DOGE's] putative goal of government efficiency, many of its actions have had the opposite effect by adding layers of review in an effort to correct the misconception that the entire federal government is riddled with waste and fraud." American science is on the ropes

@davidhanley72 @sguyenet I thought I was trying to make the point that you shouldn't heed anybody's anecdotes? Though you are right, since I worked in USA-based R1 institutions for 12 years, I do have an excellent perspective. Still anecdotal, and good for an hypothesis at best.

@AldoCompagnoni @sguyenet How you you know "I smoked and lived to 100" isn't your outlier anecdote? Also, you are commenting from germany on this USA issue?

@davidhanley72 @sguyenet This is like saying "my grandpa smoked and lived to 100". The stories of investigators obsessively saving on federal money are just as common. That's why there are cost benefit analyses to cut through individual perceptions.

Having worked in federally funded science, i’m on the DOGE side. The amount of waste was mind-boggling. I’m talking building a $5 million dollar computer cluster, spening $20K a month to power and cool it, and never using it because there was no money allocated for networking. Ran for 5 years then got decommissioned.

@cremieuxrecueil You must be talking only to the "less is more" crowd - I doubt the situation with no tradeoffs you describe here will ever be an object of contention.

You're not really a life extension advocate if you're telling people to avoid living life so they can live a few years longer. Proper life extension will confer unlimited healthspan and the ability to drink, party, enjoy yourself, and live youthfully, forever.

@micheleboldrin Ma non sta succedendo il contrario? x.com/jburnmurdoch/s…

Evidenza?

@enricomariutti @micheleboldrin Interessante notare come un argomento "negazionista" fosse proprio il "lull in climate change" degli anni ~70, che il consenso spiegata proprio con l'effetto di raffreddamento della SO2. (non ho letto gli studi recenti, e non so se siano gia' consenso)

@micheleboldrin I fossil fuels sono il maggior fattore "riscaldante" ma anche il maggior fattore "raffreddante". La lotta contro l'inquinamento sta producendo un decoupling: i filtri catturano la SO2 ma fanno passare la CO2 e il CH4. Spaccato sulla complessità allucinante dell'argomento.

Ricordi @micheleboldrin quando qua sopra (un paio d'anni fa) segnalai questa direttrice di ricerca, tra incredulità e indignazione? Ora la questione è settled.

@juliaoftoronto @KevinH_PhD @Avery_Books I suspect this will be an instant classic!

Many moons ago, @KevinH_PhD and I talked about a book we both wished existed. No fads, no weight loss hacks—just the nutrition and metabolism science. I’m thrilled to announce that we wrote it! Out September 23 @Avery_Books & available now for pre-order. penguinrandomhouse.com/books/671334/f…