Alessandro Prigione

The Impact of Mutant #Huntingtin on Neurodevelopment Unveiled through Human #Brain #Organoid Models. #BrainOrganoid By Pawel Lisowski，Selene Lickfett，@AlePrigio，et al. More Brain Organoids Research Highlights: isoor.org/brain-neural-o… Article Link: nature.com/articles/s4146…

Next up in the modelling IEM session, Dr @AlePrigio discusses developing brain organoid models for the study of #mitodisease. In addition to developing robust models, he has begun working on drug repurposing #excitingstuff #raredisease #SSIEM2024 (not brains in jars)

Beautiful run this morning for the Kastelo charity run. Thanks to the SSIEM2024 organizers! @ssiem2024_Porto

@DykstraWerner Thank you Werner for your excellent work!

Thankful to @AlePrigio for giving me the opportunity to contribute to this project during my internship time in Berlin!

@DeRubeisLab Thanks!

@AlePrigio Congratulations!

It's out! Excited to share our latest work in Nat Comms. We found that mutant Huntingtin impairs human neurodevelopment in brain organoid models through early disregulation of the mitochondrial protein CHCHD2. Thanks to all coauthors! nature.com/articles/s4146…

@ONEResearchComm Thanks!

@AlePrigio Congratulations Alessandro. You have a nice profile: 108 publications, 3x the average impact in your field, and 20 publications among the top 10% most cited in your field (twice the expected). Bravo! 👏

@Mito_Therapy Thanks Dario!

@AlePrigio Amazing paper Alessandro ! Congrats

@Pluchinolab Thanks Stefano!!

@AlePrigio 👏🏻👏🏻👏🏻

@AleParziAle Thank you Ale!!

@AlePrigio Cool, congrats Ale and team

@KajasteLab Thanks so much Anna!

@CarmeloFerrai Thank you so much Carmelo!! It has been such a long project (as you may remember..).

@AlePrigio Great @AlePrigio !!!! Congratulations to all the fantastic team!

@KurianLab Thank you Leo!

@AlePrigio Congarts @AlePrigio

@FrezzaLab Thanks Christian!

@AlePrigio great work Ale!! congratulations to you and your team!

@TheVilchezLab Congratulations David and all the team!

New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: cell.com/cell-reports/f… #ALS

@TheVilchezLab Thanks David!

@AlePrigio Congrats Alessandro and team!

@Dpla_ Thank you David!

@AlePrigio Congratulations! Nice work !

Researchers at @MDC_Berlin and @HHU_de have identified a gene that affects mitochondria in an #organoid model of #Huntington’s disease. The gene may contribute to brain abnormalities much earlier than previously thought. @NatureComms @metzgerlab @AlePrigio mdc-berlin.de/news/news/new-…

This was quite a long project starting several years ago and a huge collaborative efforts! Mainly with @HHU_de and @MDC_Berlin but also other labs in Germany, Greece and Spain! Great collaboration with co-last author @metzgerlab. And thanks to funding from @dfg_public

Great collaboration with Antonio del Sol, @OlePless, Christine Rose, @eperlste and many others. Grateful to the support from @BMBF_Bund and @EJPRareDiseases, European Commission, @cure_mito, @UMDF, PALS, and Mito Help!

Delighted to share our latest preprint! We used iPSC-derived brain organoids and deep learning screenings to identify new drugs to treat the mitochondrial disease Leigh syndrome. Graduate student Carmen Menacho received a Merit Award for this #ISSCR2024. biorxiv.org/content/10.110…