Alex Muccilli

Such an important paper! @UofTNeurology @uoftneurons

Among patients with atrial fibrillation at high risk for stroke and bleeding, left atrial appendage closure was not noninferior to medical therapy in reducing the risk of stroke, embolism, major bleeding, or death at 3 years. Full CLOSURE-AF trial results: nejm.org/doi/full/10.10… Editorial: Left Atrial Appendage Closure — Another Overused Method in Cardiology? nejm.org/doi/full/10.10…

This longitudinal, retrospective study found that the interleukin-6 receptor inhibitor tocilizumab shows promise as a potentially effective treatment in #MOGAD, and its subcutaneous administration may improve long-term therapy adherence: hubs.la/Q046cDYY0

See you on Thursday! DM for the link! 🚀

75% of Asian women with previously monophasic #MOGAD transitioned to a relapsing course after delivery, suggesting pregnancy can be considered with appropriate clinical monitoring. Study from the National Institute of Cancer Research & Hospital▶️ journals.sagepub.com/doi/abs/10.117…

This study provides valuable insights into the management of iatrogenic progressive multifocal leukoencephalopathy in patients with #MultipleSclerosis: hubs.la/Q044Lpk90 #NeuroTwitter

Tom Brady: “You need coaches that push you outside your comfort zone because that’s how you grow and that’s how you develop self confidence and self esteem. They push you to deal with failure.”

ICIs can cause 2 distinct optic neuropathies 👁️ 🔹 Papillitis – often with uveitis/VKH, better prognosis; ICIs may be resumed after recovery 🔹 Optic neuritis – linked to broader neurotoxicities, poorer outcomes (persistent deficits in up to 80%) Full text ejcancer.com/article/S0959-…

Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5). thelancet.com/journals/lance…

📢 February issue is now available ▶️journals.sagepub.com/toc/MSJ/current ...and the cover goes to @CollonguesN @CHRUStrasbourg @Inserm with their study on anti-IL6R therapy in #NMOSD and #MOGAD▶️ journals.sagepub.com/doi/full/10.11…

Kate Scott has absolutely nailed it. Every word is spot on.

I really loved this from Mikaela Shiffrin after her win yesterday. So honest and emotional when speaking about her fear of winning, knowing her dad wasn't there to see it. I think so many of us can find some magic in her words. Worth a listen.

The world has lost a shining light. @DVervoort94 walked this world with grace, compassion, and a deep passion for health equity. We are heartbroken to have lost Dom and are grieving with his family and all those around the world who knew him and loved him.

This ISC 2026 graphic is a great snapshot of the key trials. Big themes for inpatient stroke care: imaging-based selection, clearer “don’t routinely do,” refined late-window workflows, and evolving prevention/rehab data. #ISC2026 #Stroke

Ophthalmic and retinal artery occlusions, and stroke, can be iatrogenic following cosmetic facial filler injections. Possibly retrograde from supratrochlear/supraorbital/dorsal nasal arteries. Rare but devastating. Excellent Korean study, 44 patients jamanetwork.com/journals/jamao…

Life lessons from @rogerfederer (must watch) 1 Effortless is a myth 2 Belief in yourself has to be earned 3 Grit > Gift 4 Discipline is talent 5 Trust and loving the process is talent 6 You can do your best and still lose 7 Life is bigger than the court

In adults with drug-resistant #FocalEpilepsy, cenobamate was associated with greater seizure reduction and seizure freedom vs brivaracetam, lacosamide, and perampanel, but with more adverse effects. ja.ma/4qArM5u

Kobe on Excellence. Excellence is a way of life. It is a Habit. The great ones are committed to the process. They work to create winning habits each and every day. These habits become who they are. Excellence follows. 🎥 Kobe and Alabama Football

The Golden Rule when you're learning a new skill‼️👇

Baricitinib, a Janus kinase inhibitors used for autoimmune diseases such as rheumatoid arthritis and lupus, can trigger a central nervous system inflammatory-demyelinating disease. Case report from @RozitaKhalili @BagnatoLab @uthsc @VUMCDiscoveries ▶️ journals.sagepub.com/doi/full/10.11…