Alex Muccilli

3.3K posts

Alex Muccilli

Alex Muccilli

@AlexMuccilli

Neurohospitalist & teacher @UofTNeurology @SMHNeurology, @UHNSHSNeurology, @THP_Hospital. Equity, inpatient 🧠, stroke & neuroinflammation (she/her/dr).

Toronto, Ontario Katılım Mayıs 2015
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Alex Muccilli retweetledi
Alberto Vogrig
Alberto Vogrig@Vogrig_Alberto·
A breakthrough in anti-IgLON5 disease research: patient-derived autoantibodies directly trigger neuronal hyperactivity, abnormal Tau redistribution/phosphorylation, and neuroinflammation — establishing a causal link between autoimmunity and Tau pathology. science.org/doi/10.1126/sc…
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Eoin Flanagan
Eoin Flanagan@EoinFlanagan14·
Reports of the clinician’s demise are greatly exaggerated! Happy to share this editorial, led by Dr. Buciuc, on study “MOG-IgG Positivity Does Not Equal MOGAD.” Antibody positivity and criteria are powerful tools but they do not replace clinical judgment👇thejcn.com/DOIx.php?id=10…
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Dr. Brandon Beaber
Dr. Brandon Beaber@Brandon_Beaber·
In MS research, there is a strong correlation between preventing relapses and preventing disability progression, but these authors argue tolebrutinib is unique in that it prevents progression out of proportion to its ability to prevent relapses neurology.org/doi/10.1212/CP…
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Laura Vater, MD, MPH
Laura Vater, MD, MPH@doclauravater·
Four million physician hours are spent on mandatory modules each year. They represent not just clinical time lost but “evenings reclaimed and cognitive load reduced.” Redundant training and low-value modules should be a thing of the past. jamanetwork.com/journals/jama/…
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Eoin Flanagan
Eoin Flanagan@EoinFlanagan14·
So exciting to see @mlevy18 present at #AANAM on satralizumab as the 1st proven treatment for attack-prevention in #MOGAD ➡️ A wonderful day for the #MOGAD community!
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Neurology Journal
Neurology Journal@GreenJournal·
Peri-Ictal MRI Abnormalities and Risk of Unprovoked Seizures After De Novo Status Epilepticus: hubs.la/Q049Cj0R0
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Neurology Journal
Neurology Journal@GreenJournal·
Expanding the Clinicoradiologic Phenotype of the CTSA-Associated Small Vessel Disease CARASAL: A Comparison With CADASIL hubs.la/Q049C7M10
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NEJM
NEJM@NEJM·
Among patients with atrial fibrillation at high risk for stroke and bleeding, left atrial appendage closure was not noninferior to medical therapy in reducing the risk of stroke, embolism, major bleeding, or death at 3 years. Full CLOSURE-AF trial results: nejm.org/doi/full/10.10… Editorial: Left Atrial Appendage Closure — Another Overused Method in Cardiology? nejm.org/doi/full/10.10…
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Neurology Journal
Neurology Journal@GreenJournal·
This longitudinal, retrospective study found that the interleukin-6 receptor inhibitor tocilizumab shows promise as a potentially effective treatment in #MOGAD, and its subcutaneous administration may improve long-term therapy adherence: hubs.la/Q046cDYY0
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MSJ
MSJ@MSJ_Research·
75% of Asian women with previously monophasic #MOGAD transitioned to a relapsing course after delivery, suggesting pregnancy can be considered with appropriate clinical monitoring. Study from the National Institute of Cancer Research & Hospital▶️ journals.sagepub.com/doi/abs/10.117…
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Vala Afshar
Vala Afshar@ValaAfshar·
Tom Brady: “You need coaches that push you outside your comfort zone because that’s how you grow and that’s how you develop self confidence and self esteem. They push you to deal with failure.”
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