Alex

I've said many times mechanical hypertrophy is harmful for our health because it suppresses metabolic adaptation via JNK. You have more muscle at the expense of your health (mitohondria). link.springer.com/article/10.100… karger.com/ger/article-ab… frontiersin.org/articles/10.33…

Unveiling the perfect workout: exercise modalities and dosages to combat visceral adipose tissue in individuals with overweight and obesity - a systematic review with pairwise, network, and dose-response meta-analyses pubmed.ncbi.nlm.nih.gov/42098808/

Blood as the mirror and modulator of aging: mechanistic insights and rejuvenation strategies nature.com/articles/s1227…

Age-related skeletal muscle atrophy and adipose accumulation in 17 lower limb muscles: influence of lifelong endurance exercise | Physiology | American Physiological Society journals.physiology.org/doi/abs/10.115…

In wild baboons, sleep isn’t equal 🐒 Higher-ranked individuals have more fragmented rest and less sleep—likely due to closer proximity and social influence within the group. A striking trade-off between dominance and sleep quality. #SleepScience #AnimalBehavior sciencedirect.com/science/articl…

Sleep loss doesn’t just affect the brain—it disrupts the gut 🧠➡️🦠 Overactive vagus signaling boosts acetylcholine & serotonin in the intestine, driving oxidative stress and impairing stem cell function. Another reason sleep is critical for whole-body health. #SleepScience #GutHealth sciencedirect.com/science/articl…

A 16-hour fasting regimen may boost cancer immunotherapy. Transient nutrient stress reshapes tumor metabolism, increasing isoleucine in the TME and enhancing CD8+ T cell function. In mice & patients, short-term fasting improved immune response—offering a feasible way to strengthen treatment. #Fasting, #immunotherapy, #cancer, cell.com/cell-metabolis…

Vascular aging: A central driver of multimorbidity - "Proposes the “Vascular Senescence Hub” hypothesis, where vasculature actively drives systemic aging rather than being a passive victim." - "Evaluates emerging therapies, including senolytics and mitochondrial-targeted antioxidants, designed to target fundamental aging mechanisms." sciencedirect.com/science/articl…

Oral microbiome perturbations link periodontal health to cognitive ageing in a large community cohort thelancet.com/journals/ebiom…

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature cell.com/cell/fulltext/…

Circadian rhythms aren’t just about sleep—they regulate metabolism at a fundamental level. When disrupted, metabolic imbalance can contribute to disease, even acting as a signal in cancer development. Restoring these rhythms may offer new therapeutic paths. #CircadianRhythm #CancerResearch sciencedirect.com/science/articl…

Higher cardiorespiratory fitness in midlife is associated with a longer (and longer disease-free) life. Compared with low CRF, high CRF had: • a 2% longer healthspan (~1.5-year later onset of cardiovascular, metabolic, and cancer outcomes). • 9% fewer diseases. • a 3% longer lifespan.

We now exercise five times less than we did 100 years ago. Our lifestyles are accelerating aging New review @Cell_Metabolism how to counter it cell.com/cell-metabolis…

Sunlight: Time for a Rethink? 🤔 “Growing evidence shows that sunlight has health benefits through vitamin D–independent pathways, such as photomobilization of nitric oxide from cutaneous stores with reduction in cardiovascular morbidity. Sunlight has important systemic health benefit as well as risks.” jidonline.org/article/S0022-…

Chronic inflammation mediates the relationship between physical activity and telomere length link.springer.com/article/10.100…

The Compassionate Mind - In this short clip His Holiness the Dalai Lama explains why developing a compassionate mind is essential for inner peace and human happiness. When our thoughts are dominated by self-centered attitudes, fear, anger, jealousy, and distrust naturally arise. But when we cultivate genuine concern for the well-being of others, our hearts open and our minds become more transparent, honest, and peaceful. Video was originally recorded on November 19, 2010.

The Simultaneous Prevention of Multiple Diseases: A "One Ring to Rule Them All" Framework for Redox-Driven Health and Longevity mdpi.com/2072-6643/18/6…

Exercise-Induced Exerkines Modulate Autophagy: Implications for Interorgan Crosstalk in the Hallmarks of Ageing "This review summarizes current evidence on representative exerkines and their roles in autophagy-dependent inter-organ crosstalk, highlighting the exercise–exerkine–autophagy axis as a promising target for preventing and managing chronic diseases." mdpi.com/1422-0067/27/6…

Testicular aging revisited: Current understanding of mechanisms and emerging interventions sciencedirect.com/science/articl…

Mitochondrial dysfunction in urologic disease nature.com/articles/s4139…

Adipocytes as core drivers of skin aging and novel targets for regeneration link.springer.com/article/10.100…