Alex

I've said many times mechanical hypertrophy is harmful for our health because it suppresses metabolic adaptation via JNK. You have more muscle at the expense of your health (mitohondria). link.springer.com/article/10.100… karger.com/ger/article-ab… frontiersin.org/articles/10.33…

@DrMikeRoberts @DrAndyGalpin As far as I know, increasing volume should increase the sarco component and decrease the myofibrillar %. High-load training should increase the % of the myofibrillar component and decrease the sarco one. But we should see the absolute numbers too, the whole cell hypertrophy.

@DrAndyGalpin You the man Andy. I had such a great time with you. Chat soon my man.

New Perform with Dr. Andy Galpin episode: What Drives Muscle Growth & What Doesn't | Dr. Mike Roberts (@DrMikeRoberts) 0:00 Introduction 3:15 How Muscle Grows 17:39 What Drives Growth: Tension, Stress & Damage 24:08 Responders vs. Non-Responders 29:54 Hormones, Receptors & Genetics 48:01 Cell Signaling, mTOR & Myostatin 56:32 Can Some People Not Grow Muscle? 1:01:34 Training Volume for Hypertrophy 1:08:34 Loads, Reps & Stretch Under Load 1:17:13 Range of Motion, Partials & Hyperplasia 1:31:31 Injury, Unloading & Muscle Banking 1:39:32 Muscle Memory: Detraining & Retraining 1:47:42 Aging, Menopause & Anabolic Resistance 2:01:21 Concurrent Training & the Interference Effect 2:08:54 How to Combine Strength & Cardio 2:24:03 Strength Training & Mitochondria 2:25:21 Closing Thoughts Includes paid partnerships.

@DrMikeRoberts @DrAndyGalpin Hi, Mike. You should continue your work on sacro- vs. myofibrillar hypertrophy. Unfortunately, your studies didn't give us a clear answer. And we have to analyze different fiber types too. Myofibrillar adaptation is what we need. And preservation of adaptation.

@MuscleMechsLab @JSCRonline @UlsterSchSport The question is if partial stretch reps are more effective than full ROM for whole muscle hypertrophy. We can't see clear advantages at this point. When it comes to feelings, I like to do full ROM more. Feeling of completeness.

@AlexViKu @JSCRonline @UlsterSchSport Exact transmission of force through muscle and ways muscle 'should' grow arent well defined. With decent active tension in all groups youd expect some radial growth as well as longitudinal. Yes it's always interesting to see influences of other architectures

Our new 📄 in @JSCRonline "Moderate Intensity RT With Partial Range-of-Motion at Long Muscle Lengths Elicits Similar Hypertrophy and Architectural Adaptations as High Intensity RT Using Full Range-of-Motion" @UlsterSchSport journals.lww.com/nsca-jscr/abst…

@MuscleMechsLab @JSCRonline @UlsterSchSport Basically, we usually see the advantage of long muscle length training only in distal regions. But somehow LML increases hypertrophy in the whole muscle, unlike short ROM. From this point of view, LML has a clear advantage to preserve muscle mass for us as we age. 🙂

@MuscleMechsLab @JSCRonline @UlsterSchSport My hypothesis is that concentric contraction increases 'metabolic stress,' which increases hypertrophy, mostly sarcomeres in parallel. Stretching activates mechanical signals (titin), increasing mostly longitudinal growth (sarco in series).

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Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators mdpi.com/3922246 #mdpicells через @Cells_MDPI

Differential motor unit firing rate and hypertrophic adaptations of the vastus lateralis despite similar strength increases following high-load versus combined high- and low-load resistance training interventions link.springer.com/article/10.100…

@MuscleMechsLab @JSCRonline @UlsterSchSport Thanks. Interesting study. But why did you choose to use different intensities? Because it's a confounding factor here. And it's not clear if all the groups trained to failure. It's important too.

@jploenneke 20-30 RM is more effective for hypertrophy, quite the opposite from what we know. I think we need to measure growth more precisely, a minimum of one week after training.

Recent paper from our group investigating the effects of external load on changes in muscle and tendon thickness #OleMissMuscle journals.lww.com/acsm-msse/abst…

Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice nature.com/articles/s4358…

Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan Highlights: “🔘 Western and keto diets increase fat mass and frailty and reduce healthspan in aged mice 🔘 A low-amino-acid, moderate-methionine longevity diet promotes health and reduces frailty 🔘 Higher animal protein/EAA intake is associated with increased obesity and T2D risk” 🔗 cell.com/cell-metabolis…

Boundary Conditions of Retrieval-Enhanced Learning: Evidence from Contextual Learning and Retention of Second Language Multi-Word Expressions journals.sagepub.com/doi/10.1177/13…

Alcohol Intake and Health Study: No Protective Effect at Low Levels, With Mortality Increasing to 1 in 25 at 14 Drinks Per Week jsad.com/doi/10.15288/j…

researchgate.net/publication/40… Comparison of Repetition‐Based Progressive‐Overload Strategies in Resistance Training: Rest‐Pause Versus Drop Sets

Influence of the adaptation of lactate accumulation rate through physi… sciencedirect.com/science/articl…