Almut Eisele
60 posts
@AlmutEisele
Postdoctoral researcher @EPFL -transcriptional and epigenetic memory- lineage tracing- stem cells- single cells- multiomics
Inheritable 'memory' genes drive #cancer drug tolerance, but their discovery in clinical samples is a major challenge. Our new theory, moving away from Luria-Delbruck, detects them from a *single* scRNA-seq dataset! With #ArchishmanRaju led by @suvranil_1 tinyurl.com/4pef8scy
Through generation of resistant colonies from a clonal population of cells containing this dual reporter construct, we found that this memory encoding occurs in cis. (6/9)
Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint @BintuLab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.110… (1/9)
