Chromatin labeling and imaging

Illuminating microtubule architecture – Check out the associated News and Views by Rūta Gerasimaitė Gražvydas Lukinavičius nature.com/articles/s4158…

CenSpark is a dual-ligand fluorescent probe simultaneously binding inner and outer microtubule sites – a configuration unique to doublet and triplet microtubules, enabling selective live imaging of centrioles and cilia across species nature.com/articles/s4158…

News & Views in @nchembio : CenSpark offers a new perspective on microtubule organization—moving beyond tubulin to capture higher-order structure in live cells. #AcademicPublishing #ResearchImpact #imaging nature.com/articles/s4158…

Just published in @JACS_Au ! pubs.acs.org/doi/10.1021/ja… We show that the remarkable stability of proline-derived cofactors enabling efficient DNA labeling using methyltransferases—even under harsh conditions. Thanks to the contributors: @J_Bucevicius and @GerasRuta !

New Year, New Microscope! We just got upgraded to Abberior MIRAVA POLYSCOPE — confocal → MATRIX → STED. First test looks good, large area and nice STED images using our probes. @Abberior @StefanHellLabs #microscopy #livecell #fluorescence #bioimaging

New preprint! The remarkable stability of proline-derived cofactors opens efficient DNA labeling possibility using methyltransferases even at harsh conditions. biorxiv.org/content/10.648… Congratulations to @GerasRuta and @J_Bucevicius . #Biochemistry #DNA #Fluorescence

Wish all of You Merry Christmas and a Happy New Year!!! Enjoy AI-generated card for Chromatin labeling and imaging @AndImaging

New preprint! We systematically evaluate red-shifted rhodamine-based DNA probes for in vivo chromatin imaging. Congratulations to Kamila and Shalini (@ShaliniPradha19) et al. Job done at @mpi_nat . Read more if you want to know which isomer is the best: biorxiv.org/content/10.648… .

We developed 6SiR-C3-NextA, a bright far-red, cell-permeable probe, enabling selective imaging of endogenous HDAC6 in living cells. Congratulations to Van-Thang Nguyen et al. (@Eyeshield_VN_21)! Developed at @mpi_nat and published on BioRxiv biorxiv.org/content/10.648… .

Celebrating 2nd PhD student of the group! 🎓 Van-Thang Nguyen (@Eyeshield_VN_21) from the Chromatin Labeling & Imaging group successfully defended his thesis through the @IMPRS_GS program at @mpi_nat. A smooth and impressive defense — and his paper is coming soon… 👀📄

We have introduced a new biocompatible sulfonium-based building block for generation of non-cytotoxic covalent fluorescent probes. The proof-of-concept paper is out in @NatureComms : rdcu.be/eUn8F Great job done by @MarieAuvray4 at @mpi_nat !

Happy DNA day!!! 😀 #DNA #Chromatin #research

The updated Team of @AndImaging . We will keep you posted with our newest developments. Follow us: @J_Bucevicius @GerasRuta @GeorgijKostiuk @Eyeshield_VN_21 @D_Bubnyte @kenji_tori38197

We have introduced a new biocompatible sulfonium-based building block for generation of non-cytotoxic covalent fluorescent probes. The proof-of-concept paper is on BioRxiv: doi.org/10.1101/2025.0… . Great job done by @MarieAuvray4 at @mpi_nat ! Enjoy reading!

Wish all of You Merry Christmas and a Happy New Year!!! Enjoy DALL-E AI-generated card for Chromatin labeling and imaging @AndImaging

Finally, we have the 1st PhD student Shalini Pradhan @ShaliniPradha19 from Chromatin labeling and imaging group from @IMPRS_GS program at @mpi_nat . It was challenging to make the full program in a single day, but we succeed.

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)

Cost of having DNA methylation: DNA replication by DNA polymerase epsilon is a source of C to T mutations in CpGs, especially methylated ones. This expands our understanding of one of the most widespread endogenous mutational mechanisms. nature.com/articles/s4158…

A team led by Steffen Sahl & @Stefan_W_Hell @mpi_nat and @mpi_mr_hd has succeeded in measuring distances within biomolecules using the #MINFLUX microscopy method, down to 1 nanometer and with Ångström precision. Read more in our press release: mpinat.mpg.de/4816514/pr_2419

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”