Andrew Wood

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Andrew Wood

Andrew Wood

@AndrewWoodLab

Research group at the University of Edinburgh using genome editing and targeted protein degradation to study genetic disease and therapy

The University of Edinburgh Katılım Aralık 2013
362 Takip Edilen729 Takipçiler
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Andrew Wood
Andrew Wood@AndrewWoodLab·
Today in @NatureGenet, we report a saturation genome editing study that systematically dissects the degron of β-Catenin: one of the most frequently mutated regions of the cancer genome. Collab with @kiddevonline and @DeryaDOzdemir, among many others rdcu.be/e1Tvk
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nature
nature@Nature·
Nature research paper: Hepatic zonation determines tumorigenic potential of mutant β-catenin go.nature.com/4nZHB4h
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @WhiteheadInst @MITBiology @MIT and Dave Mooney @Harvard @wyssinstitute trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work
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Andrew Leduc
Andrew Leduc@_AndrewLeduc·
The big one is finally out!! In this paper, we set out to provide insight into the fundamental question; How do the individual cells from complex tissues regulate their proteomes? Brief summary of our findings 👇 biorxiv.org/content/10.110…
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Andrew Wood
Andrew Wood@AndrewWoodLab·
Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. journals.plos.org/plosgenetics/a…. Thanks again to all coauthors, reviewers and editors for a smooth publication process.
Andrew Wood@AndrewWoodLab

Happy to share our latest work and first manuscript from the Degron Tagging Cluster @MRCMouseNetwork. If you work with protein tags, particularly in tissue biology models, this should be of interest. biorxiv.org/content/10.110…

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Andrew Wood
Andrew Wood@AndrewWoodLab·
We characterise two underlying mechanisms with opposing effects on protein stability and explain their tissue-specificity, providing a rational basis for improved experimental design. Congrats to 1st author Gillian Taylor and all who contributed. Feedback welcome!
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Andrew Wood
Andrew Wood@AndrewWoodLab·
By surveying a series of CRISPR-engineered mice, we found that tags often change protein expression in some tissues but have little effect, or even opposite effects, in others. Why?
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Maria Christophorou
Maria Christophorou@MAChristoLab·
The product of our long-standing collaboration with the @lwalport lab is now in print 🥳 Congratulations to first authors @TeresaBertran & @RobertW48522313, our collaborators @VeniPap, @IVAramburu, @TessaSwanton and everyone who contributed to the study. nature.com/articles/s4146…
Maria Christophorou@MAChristoLab

We are very happy to share the result of a wonderful collaboration with @lwalport lab, on the development of a new suite of PAD4/PADI4 modulators A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation biorxiv.org/content/10.110…

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Green Ahn
Green Ahn@Green_Ahn·
Excited to share my PhD work, out now in @ScienceMagazine ! What governs successful lysosomal degradation of membrane proteins mediated by extracellular degraders? Can we improve degradation efficacy? science.org/doi/10.1126/sc…🧵(1/n)
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Jeff Nivala
Jeff Nivala@jeffnivala·
Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…
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Jeffrey Flier
Jeffrey Flier@jflier·
What if I told you that I co-founded a startup in 1987 that obtained world-wide rights to GLP1 as a metabolic Rx, collaborated with Pfizer to show key activities, & abandoned it in 1990 when Pfizer lost interest? I tell the previously untold tale in an open access paper now up in Perspectives in Biology and Medicine. Enjoy! muse.jhu.edu/pub/1/article/…
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Keşfet

@NatureGenet @UniLeidenNews @EdinburghUni @kocuniversity @MazharAdli @DeryaDOzdemir @stark_lab @mike_tilapia