Mike Gallagher

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Mike Gallagher

Mike Gallagher

@GeneticsMike7

Geneticist and stem cell biologist studying epigenetics and neurological disease @WhiteheadInst @MIT. B.S. @Muhlenberg Ph.D. @Penn

Katılım Mayıs 2021
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @WhiteheadInst @MITBiology @MIT and Dave Mooney @Harvard @wyssinstitute trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work
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Rad Rad Doc
Rad Rad Doc@RadRadDoc·
@DrLizaMD 300K seems like a steal nowadays for combined undergrad/med school debt. Isn’t that crazy?!
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Liza Lockwood
Liza Lockwood@DrLizaMD·
Medicine is the only profession where people willingly give up their youth to study for twelve years beyond high school while accumulating interest on $300K worth of student debt, only to be told they’re: 1) Pharma Shills 2) Doing it all wrong 3) Unsafe without supervision from folks with a fraction of the training As thanks, Doctors work nights, weekends & holidays, pay thousands out of pocket for ever increasing “merit badges” like “maintenance of certification”… And still have to ask for permission to prescribe drugs or perform a procedure….from people who aren’t at the bedside. Those bureaucrats also give them 10-15 minutes to spend with each patient, while documenting minutiae that is completely irrelevant to care. They top off the week with uncompensated documentation time so hospitals can make more money off of their work. God forbid they prescribe an opioid… That’s career ending.
Liza Lockwood@DrLizaMD

Let them practice medicine without Monday morning quarter backing from administrators, insurance companies, malpractice lawyers, the academy & the state. It’s a perfect storm for the medical profession. At the moment, doctors have all of the liability and none of the autonomy to treat patients.

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Todd Lencz
Todd Lencz@ToddLencz·
@GeneticsMike7 @SashaGusevPosts “Success rate” refers to a proposal (combined across the A0 and A1 submissions), whereas the data from Sasha’s chart refers to the impact score of a given submission
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@SashaGusevPosts Interesting, if you go to the success rate tab, which shows all competing awards at the top, success rate has hovered around 20% since 2005 (not including 2025).
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Michael Eisen
Michael Eisen@mbeisen·
Anyone with even a passing knowledge of @NIH funding will know this is complete bullshit as it counts every R01 year as a separate R01, and even then these numbers are inflated relative to what you can easily look up in REPORTER. Not to mention the fact that being able to get multiple R01s is a poor measure of impact.
Mukund Iyengar@mukundiyngr

Ever wondered who the real rockstars of R01s from the past 5 years? We ranked the most funded PIs in cancer R01s from 2020–2024. Anyone with persistent effort can (maybe) win one R01. Winning 38–48 of them over 5 years is something else entirely. R01s flow towards people whose ideas repeatedly translate into durable programs. Durability means: • hypotheses that age well • biology that generalizes • institutions that trust you with long arcs • and ideas NIH is willing to underwrite repeatedly ======== Meet the rockstars, their institutions, and an examplary funded research: Allen Gao (University of California, Davis @ucdavis) 48 R01 awards | $14.6M Sample Award: 5R01CA271327 Novel therapeutics dual targeting intracrine androgen synthesis and AR for advanced prostate cancer Xiaoqi Liu (University of Kentucky @universityofky ) 46 R01 awards | $20.3M Sample Award: 5R01CA272483-03 Targeting the PLK1/PDCD4/mTORC2 signaling to treat castration-resistant prostate cancer Tim Rebbeck (Dana-Farber Cancer Institute @DanaFarber) 43 R01 awards | $10.4M Sample Award: 5R01CA259200 Genetic and genomic variation in prostate cancer Shoujiang Gao (University of Pittsburgh School of Medicine @PittTweet) 42 R01 awards | $21.3M Sample Award: 5R01CA284554 Impact of microbiota on AIDS-Kaposi’s sarcoma development and therapy James Basilion (Case Western Reserve University School of Medicine @cwru) 39 R01 awards | $18.2M Sample Award: 5R01CA255925 Highly selective targeted theranostics for prostate cancers Binghui Shen (City of Hope Beckman Research Institute @cityofhope) 39 R01 awards | $16.6M Sample Award: 5R01CA233664 DNA repair gene mutations and prostate cancer Daniela Bota (UC Irvine @UCIMedSchool) 39 R01 awards | $10.4M Sample Award: 5R01CA263806 Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system Nan Hao (UC San Diego @UCSDMedSchool) 38 R01 awards | $17.1M Sample Award: 1R01AG086348 Engineered genetic clocks for control of cellular aging Zhenghe Wang (Case Western Reserve University School of Medicine @cwru) 38 R01 awards | $16.8M Sample Award: 4R01CA260629 Role of PTPRT in colon cancer progression and metastasis Tony Faber (Virginia Commonwealth University School of Medicine) 38 R01 awards | $16.6M Sample Award: 5R01CA276207 MYCN drives a ferroptotic vulnerability in neuroblastoma

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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@Siphonhump @EBasilion @mbeisen @NIH Well, yes, that is what non-profit researchers do. Universities, institutes, some government, etc. Industry tests drugs on patients and gets them approved for use, and this is almost entirely privately funded.
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@Siphonhump @EBasilion @mbeisen @NIH 2/ FWIW, 1-5% is the official number for NIH funds that support biopharma, and 0-5% is a reasonable estimate of the % of FDA approvals that originate from non-profits.
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@Siphonhump @EBasilion @mbeisen @NIH Sure, I’m just saying the vast majority of drug development is done in biopharma, and the vast majority of NIH funds is used for non-profit research. I’m not saying it’s 100%. Not sure about the last statement, as it’s very difficult to quantify.
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@sciencey274807 @mbeisen @NIH Yes reducing PhDs awarded (and postdocs coming to train in the U.S.) would also relieve the competition. Every potential change has massive cost/benefit complications and none have been widely popular other than increased funding, which is only a partial solution.
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sciencey
sciencey@sciencey274807·
@GeneticsMike7 @mbeisen @NIH Two ways to reduce hyper competitiveness: increase funding, or reduce hiring by academia, such that fewer PhD’s are produced. Too many labs churn out 40 Ph’d in a PI lifetime. Also get rid of the labs which have established pubpeer records.
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@ThatEricAlper @sebatlab No, nostalgia just makes everything seem better in hindsight. At the time early 90’s was considered one of the worst periods in modern music, and looking back, it still is.
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Eric Alper 🎧
Eric Alper 🎧@ThatEricAlper·
Music was pretty amazing in 1991, huh?
Eric Alper 🎧 tweet media
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@sciencey274807 @mbeisen @NIH It’s more the opposite. Insufficient funding creates hypercompetition that disincentivizes emphasis on replication and performing replication studies.
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sciencey
sciencey@sciencey274807·
@mbeisen @NIH Sure. But how much of this published is irreproducible? Current estimates suggest up to 70%. So I see a lot of wasted money, quite frankly.
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@kph3k Excited to read! Recent Nature Genetics perspective on poor diagnoses in psych GWAS made me worried about genetic studies more generally - how strong do you think the diagnostic evidence is for these cases?
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Kathryn Paige Harden
Kathryn Paige Harden@kph3k·
New work! We analyzed genetic data from 4 million people to identify genetic variants broadly associated with disinhibition problems--from hyperactivity in childhood to risky sex in adolescence to antisocial behavior and suicidality in adulthood.
Camille Michèle Williams@Cognitive_Camz

Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/2026.…

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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@davidasinclair @glukianoff @Nature Don’t we know that this is true for all matter, but 1) wavelengths are not meaningful from a practical perspective for anything above atoms/molecules, and 2) decoherence further renders the duality not noticeable at large scales?
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David Sinclair
David Sinclair@davidasinclair·
The double slit experiment is one of the weirdest results ever. Particles don’t have a position until they are observed. New @nature paper shows this is true for molecules with as many as 7000 atoms. Someone should definitely try this with viruses nature.com/articles/d4158…
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Eryney
Eryney@eryney_ok·
You don't hear much about systems biology anymore. Lesson in there somewhere.
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@exquizitely Did anyone else get those monthly PC Gamer mags and CDs with demos of multiple games per month? Or maybe it was CGW, can’t remember. Coconut monkey!!!!
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exQUIZitely 🕹️
exQUIZitely 🕹️@exQUIZitely·
Looking at the second half of the 90s, if you were a fan of RTS games during that time - how blessed were we? This is not even a complete list, but simply one game per year from 1995 to 2000. Gaming just felt different then. Whether in single-player mode or - even better - in LAN sessions with your friends; those memories will never fade. Sometimes it was really hard to decide because there were simply too many great games to choose from! ⚔️ Warcraft 2 (1995) ⚔️ Command & Conquer: Red Alert (1996) ⚔️ Total Annihilation (1997) ⚔️ StarCraft (1998) ⚔️ Age of Empires 2 (1999) ⚔️ Dark Reign 2 (2000)
exQUIZitely 🕹️ tweet mediaexQUIZitely 🕹️ tweet mediaexQUIZitely 🕹️ tweet mediaexQUIZitely 🕹️ tweet media
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Sophia Liu
Sophia Liu@immunoliugy·
We have a search for faculty in neuroimmunology @ragoninstitute jointly with MGB Neurology! Apply and send a 3-page research statement, CV, and names and contact information of 3 references to: ragonfacultyrecruiting@mgh.harvard.edu PhD, MD/PhD, MDs welcome #AcademicJobs
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@JSheltzer @arjunrajlab 2/ the splicing shouldn't matter for a protein-mediated effect unless it produces an mRNA that isn't matched by the cDNA rescue. So I suspect that 1) failed rescue experiments don't get published and 2) other genes/phenotypes are more likely to be affected than that being tested
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Mike Gallagher
Mike Gallagher@GeneticsMike7·
@JSheltzer @arjunrajlab 1/ Probably because the phenotype being studied is dependent on the protein, and the protein level does not need to precisely match the endogenous to see a decent rescue? The introns might contain enhancers, but this is irrelevant as long as cDNA produces enough protein.
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Jason Sheltzer
Jason Sheltzer@JSheltzer·
I have almost never seen a published experiment in which wild-type cDNA fails to rescue a CRISPR knockout. What can we conclude from this?
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Keşfet

@RadRadDoc @DrLizaMD @ToddLencz @SashaGusevPosts @Siphonhump @EBasilion @mbeisen @NIH