Ankit Jain MD

@Abhilasha21822 Brilliant!

Tongue findings in Sjögren syndrome and psoriasis : Fissured tongue 👅 An often overlooked oral clue. Also known as scrotal tongue, it presents as grooves or fissures on the dorsal surface of the tongue. Common patterns include: • Central longitudinal • Central transverse • Lateral longitudinal • Branching • Diffuse #worldrheumatologyforumpearls

#WATCH | They claimed it was destroyed. India flew it on Republic Day. From Pakistan’s claim in May 2025 to Kartavya Path on 26 January 2026 Rafale BS-022 flew in the Sindoor Formation, fully operational, fully visible. Facts don’t argue. They fly. #Rafale #IndianAirForce #IAF #RepublicDay2026 #SindoorFormation

New Oral Psoriasis Treatment Shows Impressive Results! Icotrokinra — a targeted oral peptide that blocks the interleukin-23 receptor (IL-23R) — just delivered strong Phase 3 data in plaque psoriasis. 📊 ICONIC-LEAD Trial (N=684): • Moderate-to-severe plaque psoriasis (adults + teens ≥12 yrs) • Randomized 2:1 to once-daily icotrokinra 200 mg vs placebo 🎯 Primary endpoints at Week 16: ✅ IGA 0/1 response: – 65% icotrokinra vs 8% placebo (P<0.001) IGA = Investigator’s Global Assessment: a 0–4 scale of skin severity*  • 0 = clear skin  • 1 = almost clear  • IGA 0/1 = clear/almost clear with ≥2-point improvement ✅ PASI 90 response (≥90% improvement in Psoriasis Area and Severity Index): – 50% icotrokinra vs 4% placebo (P<0.001) ✨ Complete clearance: • IGA 0 (fully clear): 33% vs 1% • PASI 100 (100% clearance): 27% vs <1% 🛡️ Safety (Week 0–24): • Adverse events: 49% in both group • Common AEs: nasopharyngitis, upper respiratory infections • Stable safety profile with continued dosing 💊 Takeaway: Icotrokinra may deliver biologic-level clearance — now in a once-daily oral pill. A potential game-changer in psoriasis care. 🧪 Trial: ICONIC-LEAD (NCT06095115) | Sponsored by Johnson & Johnson #Psoriasis #IL23 #Icotrokinra #DermTwitter #MedTwitter #Autoimmune #Immunology #ClinicalTrials #Rheumatology #Immunology #Sullysrounds #MedX #Medtwitter #Mnemonics #Medicine #History @DrAkhilX @IhabFathiSulima @Janetbirdope #MedTwitter #rheumtwitter @CelestinoGutirr

@RiteshRheum @drmollythabah @AishuGopal @chengappa_kg @IndianRheum @eular_org Congratulations @RiteshRheum

Honoured to present my oral abstract at the prestigious #EULAR2025 in Barcelona! Grateful to my mentors at JIPMER for their constant guidance. Special thanks to the IRA group for their unwavering support. #Rheumatology #EULAR

🇮🇳🏆 HISTORIC WIN FOR INDIAN RHEUMATOLOGY Proud to share that Team CAR TITANS has won First Place (Gold Medal) 🥇 at the ACR 2025 Knowledge Bowl 🎓 — and we also received the Team Spirit Award 💫. This is the first time an Indian team has won the Knowledge Bowl — a proud milestone for Indian rheumatology on the global stage. 🎉 Grateful to my mentor @sarath_rheum , my colleague @ Dr Ritesh Mishra, and our institution @kimshospitals (Secunderabad) 🏥 for unwavering support 🙏. This victory reflects collaborative learning, rigorous training, and our commitment to better patient care and scientific progress 🔬📚. We came, we saw, we conquered. 🚀🏆 Onward and upward — from India to the world 🇮🇳 #ACR2025 #KnowledgeBowl #Rheumatology #CARTITANS #TeamIndia #IndianRheumatology #KIMSHospitals @IndianRheum

@DrMohithreddy @sarath_rheum Congratulations

😻Favourite Nutritional Councelling for a Rheumatologist #GOUT diet 🍛A disease with robust evidence for dietary modifications A thread…. Do 🔖 bookmark! 🚨‼️

🧵 Lupus Anticoagulant testing — explained like a story Imagine you’re in the lab. A patient’s APTT is prolonged. Now the question begins: Is it a factor deficiency or a Lupus Anticoagulant (LAC)? There are 3 detective routes to solve this 🕵️‍♂️👇 @DrAkhilX @IhabFathiSulima @Janetbirdope @Lupusreference @RheumNow #MedTwitter #RheumTwitter @drkeithsiau @CelestinoGutirr

Tweet 1/12 🧵 🩻 X-RAY IN RHEUMATOLOGY: Essential Patterns Every Rheumatologist Should Know Plain radiography remains the cornerstone of MSK imaging in rheumatology - serving as both diagnostic tool and outcome measure for monitoring disease progression A thread on key patterns 🧵👇 @DrAkhilX @IhabFathiSulima @DurgaPrasannaM1 @nileshnolkha @RadMasterclass #Rheumatology #MedTwitter

Can someone please enlighten me on the role of Widal in 2025? Almost every society has abandoned it, including WHO guidelines, because of its poor reliability, pathetic sensitivity, and dismal specificity. Yet a majority of doctors still order Widal for a 3-day fever and prescribe 5–7 days of antibiotics/injections… even when the patient clearly has URI symptoms. Today I met a man who said he had “typhoid” 5 times in the past year. His records showed 17 antibiotic courses. Each time, the doctor told him: “It’s typhoid, take this for faster recovery.” Every single diagnosis was made on Widal. This is absurd. More than diagnosing enteric fever, Widal seems to have become a tool to justify antibiotics and boost clinic incomes. It’s high time we abandon this nonsense. It drives massive antibiotic misuse. Discourage anyone who even orders Widal, and stick to ethical, evidence-based diagnosis of enteric fever.

🧵 ANA Testing in Rheumatology — Masterclass for Doctors & MedTwitter 1/ 📢 What’s ANA? ANA = Anti-Nuclear Antibodies. It’s a surrogate marker for >50 nuclear antigens (Ro, Sm, dsDNA, La, Scl-70, etc). ✅ Can be positive in many CTDs ❌ Positive ≠ disease ❌ Negative ≠ rule out all CTDs.

A meteor didn’t cause the Younger Dryas climate shift and mass extinction. The impact theory is a Trojan Horse, smuggling false narratives into climate history. Everyone pushing this theory wants to keep you blind to the reality of cyclical catastrophes and what is coming. One of the signs of catastrophic climate change is geomagnetic excursions and the weakening of the Earth’s magnetic field. This is well-established, yet deliberately denied by the scientific narrative because it would make billions of people uncomfortable about what’s coming, and that would disrupt the elites’ plans for survival. Dark thread about our true history! (1/10)🧵

Emapalumab Approved for MAS in Still’s On June 27th, 2025, the FDA approved emapalumab for macrophage activation syndrome (MAS) in known or suspected Still’s disease (including both adult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (sJIA)) with inadequate response or intolerance to glucocorticoids. buff.ly/ZC7jT7e

Long post. But I believe it’s important. Hope it is shared widely so that it reaches @PMOIndia, @HMOIndia, @MIB_India ----- Operation Sindoor has united all of India beyond politics, religion, caste, or region. This unity must be preserved and built on. While politics may erupt, and rightly so in a democracy, we all can agree that foreign entities should not interfere in our country and sow seeds of discord. However, this is happening till date and there seems to be an national apathy towards fixing the issues in India's SM, OTT, & media landscape. It is my humble request to the MIB to start acting now. And take concrete steps to cleanse Indian social media and media from foreign interference, toxic content, hate, and divisiveness. Here are the important issues: 1) Foreign influence ops We all SM users have been aware of fake “account farms” operated by Pakistan, China, Turkey, and other countries for many years now. They are: - using fake indian named accounts - planting discord among Indians - inciting communal, regional, & caste hate - interfering in our politics - spreading hate against Indians in the world - making our neighbors hate us - dehumanizing and delegitimizing Indians - spreading fake news on India - hooking our youth to perverted content - radicalizing young Indians in ideology Many issues we observe online, that turn into self-blame and internal strife, escalating into actual street conflicts and protests, are being deliberately seeded by fake account farms. They operate under various false identities, such as INC supporters, RSS workers, Biharis, Tamils, Hindus, Muslims, Buddhists, Dalits, Brahmins, Sikhs, etc They’re deliberately sowing seeds of hatred and division in India. It’s natural for people to take sides when an issue is raised, and this will attract more people into the hate and fight spiral, which will appear organic. We must act immediately against this grave threat to our country. However, we must avoid reacting impulsively. For example, suddenly sending a list of accounts to be banned to an SMP. This national security threat demands a systematic approach. Not knee-jerk reactions because the PMO or HMO took notice. Issuing a list of account bans now and then won’t solve the problem. 2) SM companies acting with impunity SM platforms are not taking action against blatantly racist, dehumanizing, and genocidal hate against Indians. Even when we report posts from accounts that literally have names like “Kill all Pajeets” posting content like “Indians are cockroaches who all need to be terminated,” we get a “we found no violation” response. How is this allowed? Isn't it a shame for a $4 trillion power? We really need to hold SM companies accountable. As the first step, create an independent reporting mechanism for SM, OTT, and media content for citizens to use easily. Europe uses such a system which companies need to provide for every post, content, and media article. Now, based on crowd-sourced reports, once a content is deemed dangerous, establish a automated system to ensure companies promptly comply with GoI notices. Use their own definitions of content violations and their own system of strikes, suspensions, and bans. First, clearly outline the red lines and the associated fines. For example, we can implement a policy that throttles access to SM platforms by our ISPs in case punitive action is needed, instead of outright banning them. This system should slow down their access speeds, incurring significant financial losses for them until they take action or face a temporary ban. 3) Foreign content in Indian media: Many vernacular media, and even national media, seem to be funded by foreign entities carrying their news, content, and propaganda quite blatantly. Also, in the name of debate shows and free speech by "guests", some channels are blatantly promoting anti-India and enemy propaganda even during a time like war. Operation Sindoor presents an opportunity and the right time to end this. Identify these media by analyzing their content. And end it. Please set up a media monitoring cell if it doesn’t exist. AI monitoring sounds cool and can be done at leisure. For now we just need an old-school media and SM monitoring center covering all regions & languages. 4) Vulgarity and obscenity exploding on SM: Perverse and vulgar content is being widely circulated on SM and OTT services in India. In recent years, OTT platforms and production houses have sprung up literally for just making soft porn. Incest, perversion, sexual aggression, infidelity, and voyeurism are all being normalized. How can India, as a civilization, culture, and nation allow this? We must take immediate action to address the pervasive issue of such content corrupting our youth. We cannot afford to let it pass. ----- These are, what I believe, some of the main SM/OTT/Media issues we need to address to protect our society and sovereignty. And my humble suggestions on how to deal with them. The recent despicable attacks on Vikram Misri, Sophia Qureshi, and Prime Minister Modi even during Operation Sindoor, seeded by the adversary, serve as a stark wake-up call.

THREAD: The Ghost Who Stared Back: Ajit Doval’s Secret War for Bharat Some heroes hold swords. Others walk into the enemy’s den wearing a smile, a fake beard, and no backup. Ajit Doval was never just a man. He is Bharat’s eyes in the dark, its mind in the shadows, and when needed, its wrath in silence. From disguises to diplomacy, espionage to execution; Ajit Doval’s life isn’t a story. It’s a multi-decade operation. Let me tell you a story. 1/

@hyderabaddoctor Excellent case! Congratulations!!

Young man suffered from severe pain in legs for two years, and had given up hope of getting better… Patient details ▶️40-year-old Mr. Mukund (name changed) presented with severe pain affecting both legs for two years. Pain affected both feet, calves and thighs. Pain was present throughout the day, however, it worsened during the nights. ▶️In addition to pain, he also suffered from burning sensation of legs. ▶️He had consulted several doctors for his symptoms. One of the doctors detected mild vitamin B12 deficiency, and he was treated with vitamin B12 supplements. There was no improvement. ▶️Another doctor diagnosed fibromyalgia and treated him with gabapentin and duloxetine, with he had minimal improvement. However, he continued to suffer from pain. ▶️When he came to me, he was in tears. He did not expect any miracle, however, he wanted to know what disease he was suffering from. ✅Important Clinical Clues ▶️Detailed history revealed two additional symptoms- sleep disturbance and constipation. He had severe insomnia and could barely sleep for 4 hours. He had constipation too and passed stools once in 3-4 days. ▶️Clinical examination revealed myokimia (continuous rippling movements in calf muscles). This was confirmed by needle EMG studies too. ▶️At this point, I suspected a diagnosis (even though it is a rare condition), and asked for the specific blood tests (VGKC antibodies). Final Diagnosis ▶️CASPR2 Antibodies in the serum were positive. Now we finally had a diagnosis. It was CASPR 2 antibody positive Morvan’s syndrome. ▶️Reports took a few days to come, during which he presented to the emergency with low serum sodium (117)- hyponatremia. Management and Outcome ▶️Sodium correction was done. He was treated with a 5-day course of methylprednisolone (IVMP), which was followed by a 5-day course of IV immunoglobulins (IVIG), as IVMP did not result in satisfactory improvement. ▶️Patient showed excellent improvement, and his pain had reduced by 80% two weeks after treatment. His sleep also improved. Dr Sudhir Kumar MD DM 27-04-2025

Can we have the benefits of steroids without their notorious side effects? Vamorolone, a novel dissociated steroid, shows promise in TNF-α-driven arthritis mice: — Equal anti-inflammatory power as prednisolone — Resistant to 11β-HSD1 metabolism — No adrenal atrophy, muscle wasting, or bone suppression — Effects sustained even in 11β-HSD1 knockout models A potential game-changer for safer long-term GC therapy See the link fir further reading👇 doi.org/10.1093/rheuma… #Rheumatology #SteroidRevolution #Autoimmune #Vamorolone #TNFtg #Rheumatology #Immunology #Sullysrounds #MedX #Medtwitter #Mnemonics #Medicine #History @DrAkhilX @IhabFathiSulima @Janetbirdope @Lupusreference @RheumNow #MedTwitter #RheumTwitter

Jains have India's highest literacy rate at 94.1%. 70% of Jains live in the top wealth quintile (Source: NFHS-4, 2018) Jains, less than 0.5 % of India’s population, contribute ~20% of income tax, the highest per capita income tax. Let's discover what makes this community home to the most Indian billionaires. Consider a bookmark or a re-tweet to revisit later.

@musk_news13 06

@deepti_pramod Congratulations!

Delighted to share that I have successfully completed my DM in Rheumatology. Grateful to my mentors, teachers, and colleagues for their invaluable guidance, and to my family for their unwavering support throughout this journey. Dr. Deepti Agarwal, MBBS, MD, DM (Rheumatology)