Ankur

If only we can come to terms with this idea of fairness, we can avoid a lot of unnecessary angst and heartburn..

@anishmoonka “Too much” is the key word here. You take too much of any medication and you end up in a hospital bed with various kinds of reaction, some of which can be fatal..

Take too much Ozempic, and your brain stops wanting things: food, sex, even the urge to get out of bed. People end up in hospital beds for days, staring at the ceiling, feeling nothing. The medical name for that state is anhedonia, and it tells you how the drug actually works. Ozempic, Wegovy, and Mounjaro all belong to the same drug family, called GLP-1s. They kill hunger. They also quiet almost every other craving your brain produces. Inside your brain there is a small region that makes a chemical called dopamine. Dopamine is your brain’s “this is worth wanting” chemical, the reason you reach for one more bite of pasta, refresh your inbox one more time, or pick up your phone every few minutes. GLP-1 drugs reach that region and turn the dopamine down. The right dose dampens the loudest craving first: food. Take too much, and the volume drops on everything else, sex, exercise, work, even the urge to get out of bed in the morning. Anhedonia is the medical name for not feeling pleasure from anything at all. It looks identical to deep depression. The good news is that anhedonia from GLP-1s has an off switch: once the drug clears your system, the wanting comes back. The FDA has logged over 1,150 reports of bad reactions tied to compounded GLP-1s through July 2025. These are custom-mixed versions made by smaller pharmacies. In many of those cases, patients accidentally took five to twenty times their prescribed dose. The cause is usually confusion between milliliters and units when measuring out a dose with an insulin syringe, since compounded versions come in plain vials instead of the pre-filled pens that brand-name Ozempic uses. About 15 million Americans currently use a GLP-1, roughly one in eight adults. Around 75% of them eventually quit. Cost and side effects are the top reasons. A growing number describe a third reason that patients call “the lights dimming,” a flat, gray feeling across the whole day that doctors now recognize as anhedonia caused by the drug itself. This same mechanism has caught pharma’s attention. Eli Lilly is now running two large clinical trials with a combined 2,200 patients to see if a GLP-1 drug can treat alcohol addiction. The bet is that the same brain switch that turns off cravings for food can also turn off cravings for alcohol, cocaine, nicotine, and gambling. A 2026 psychiatry review put it bluntly: doctors should be treating these as psychiatric drugs, because that is what they have turned out to be. The drug works by quieting your brain’s signal that something is worth wanting. A normal dose turns the volume down on food cravings. Push the dose too high, and everything else goes quiet too.

AI agents have a Principal - Agent problem too 😳

Five years ago, the team at @GalaxEye were students at IIT Madras, chasing what many would have called an “outrageously ambitious” dream. Yesterday, they launched Mission Drishti, the world’s first OptoSAR satellite. There’s a simple but powerful lesson here: leapfrogging the world begins with a leap of faith. By combining optical and radar imaging into a single platform, they didn’t just improve on what existed, they reimagined what was possible. They’re showing us that the way to take a place on the global stage, is not by catching up, but by changing the game. They’re my #MondayMotivation

Today is World Liver Day 2026. Here are 8 things your liver actually wants you to know. 1 There is no such thing as a "liver detox." Your liver runs phase I and II detoxification 24/7 on its own. No juice cleanse, no milk thistle, no herbal detox speeds this up. In fact several have caused liver injury - the opposite of the claim. 2 Alcohol has no safe dose. Liver harm begins from the first drink. The old "moderate drinking is protective" myth came from flawed studies contaminated by abstainer bias - now debunked by Mendelian randomization. Zero ml is best. 3 "Natural" supplements are now a leading cause of acute liver failure. Ashwagandha. Green tea extract. Garcinia. Kratom. High-dose turmeric. Giloy/Tinospora. They dominate drug-induced liver injury registries across India, the US, and Europe. Natural ≠ safe. 4 Coffee is genuinely liver-protective. 2–3 cups/day (caffeinated or decaf) lowers the risk of fibrosis, cirrhosis, and liver cancer. One of the very few dietary interventions with real, replicated evidence. 5 Fatty liver (MASLD) now affects ~1 in 3 adults worldwide. A 7–10% body-weight loss: • clears Liver fat • reduces inflammation • can regress early fibrosis No approved drug currently beats this. Your plate and feet are the first-line therapy. 6 Sugar-sweetened drinks independently cause fatty liver. Fructose is metabolized almost entirely by the liver - straight into fat. One daily soda raises MASLD risk even after adjusting for total calories. Lesser is better. 7 Get vaccinated against hepatitis B. Get screened for HBV and HCV at least once in your lifetime. HBV vaccine prevents >95% of chronic infection, cirrhosis, and liver cancer. Hepatitis C is curable in 8-12 weeks with >95% success - but most carriers don't know they have it. 8 Exercise protects the liver independent of weight loss. 150 min/week moderate OR 75 min vigorous activity reduces liver fat and stiffness - even when the scale doesn't move. Movement is "medicine". 🫂 PS: we also need a liver emoji

Ever wondered how we turn silicon wafer into chips? We did @hackerfabindia and are making a student built chip fab. Come visit us for a lab open day as we demonstrate our systems at IITB on Wednesday 15th April, 2-5pm to learn more. Signup link in comments.

Harshita Arora (@aroraharshita33) just became a General Partner at Y Combinator, making her the youngest in the accelerator’s history. She’s 25 years old, which is young enough that most VCs her age are still grinding as associates, hoping to make principal in five years if they’re lucky. She also dropped out of school at 15, which is the kind of detail that would normally disqualify you from every traditional path to venture capital. Between dropping out and becoming a partner... she discovered coding at 13, built a crypto portfolio tracker at 16 that Apple featured in the App Store, got it acquired, and won India’s Bal Shakti Puraskar (one of the country’s highest honors for young achievers). Then she got an O-1 visa, moved to SF, and applied to YC with her co-founder. Their idea got killed by Covid three weeks into the batch. They had zero background in trucking, zero background in payments, but had a dead startup with 3 months left to figure something out. So Harshita spent weeks visiting truck stops across California, talking to drivers, watching how they paid for fuel, and realizing that the entire payments infrastructure for trucking was totally broken. Ancient systems, hidden fees, rampant fraud, still running on technology from the 1990s despite moving billions of dollars. She built AtoB to fix it. Stripe for Trucking. A modern fuel card with transparent pricing, instant payouts, and financial tools that don’t feel like punishment. Today AtoB is a Series C company serving over 30,000 fleets across the US, processing millions in payments daily, and building the financial infrastructure that the backbone of the economy actually deserves. Now she’s a YC partner at 25, which is absurd when you consider that most VCs spend a decade climbing the ladder at banks or consulting firms, collecting the right credentials, and Harshita skipped the entire ladder and built a $700M company instead. Credentials stop mattering when you build something that works, and this is one of the embodying principles of YC, so it is great to have seen her so active this last year in supporting YC batches as visiting partner, and now a GP. Maybe as batches skew younger (like my post yesterday) partners will too...

@pitdesi You will miss the "Wabi Sabi" of making tea and the mess there of... :)

Cool product for chai lovers. I always end up babysitting chai on the stove to stop it from boiling over, and half the time I still make a mess. The Loka solves that in a clever way and makes great chai. $150, but it is a really nice product weareloka.com

@Suryanshti777 AI

Everyone is talking about Gemini... but most people are using it like a toy I compiled 700+ mega prompts that turn it into a full productivity engine. This pack is worth $500. Today, it’s free (Only for First 4500) How to get it: Follow (@Suryanshti777) MUST Comment “AI” and I’ll send it

@piyascode9 Gemini

Google Gemini is the smartest AI right now. But 90% of people prompt it like ChatGPT. That's why I made the Gemini Mastery Guide: → How Gemini thinks differently → Prompts built for Gemini → 2000+ AI Prompts Comment "Gemini" and I'll DM it free.

@Mishi_2210 1050

Answer is not "300" Tell me the answer and win $1000

@coldemailchris Prompts

AI does 90% of our initial GTM strategy formulation all in just these 6 prompts. This has been a MASSIVE unlock for speed to winning GTM for our diverse client base. Here’s what these prompts cover: 1/ Deep Market Research Generates all key GTM-relevant information about the target company to use as foundational context 2/ TAM Mapping Identifies all relevant industries/sub-industries, along with market size, value, and growth data 3/ ICP Modeling Builds ICPs from TAM outputs, ranks segments by priority, defines ideal personas, outlines their pains/needs, and provides initial messaging angles. 4/ Company Account Sourcing Finds the best databases, directories, scrapers, and niche sources to acquire accurate company data for any targeting requirement. 5/ Targeting Keywords Generation Creates precise industry/persona keyword lists for database filtering (e.g., Apollo) that outperform broad industry filters. 6/ Messaging Creation Generates multiple email script variations—different lengths, offers, pain points, case studies, and complexity—using context from earlier prompts. Want these copy-and-paste prompts for yourself? 👉 Comment "Prompts" and I'll DM you this document + LLM project you can use to extract the AI prompts. (Must be following to receive)

@deepigoyal Do people age slower in space eg ISS? 🧐

How did I come across this? I’ve spent years optimizing my health and performance. I’ve tracked my blood. I’ve fasted, trained, meditated, submerged myself in ice, sat in hyperbaric chambers, and taken countless supplements. Staying healthy is hard. It takes too much time. One day, I wondered if there was a leverage point that humanity had missed altogether. But how could that be? Humanity has been obsessed with longevity for millennia. If a straightforward answer existed, would we not have found it by now? But usually, the answers to the most complex problems are surprisingly simple. I thought that the only way humanity could have missed a big leverage point, was if the answer was so obvious, that all of humanity looked right past it. I racked my brain, searching for what that overlooked factor could be. What is constant across all organisms, inescapable by mutation or adaptation, obvious yet invisible? And then, a word surfaced in my mind. Gravity.

Without telling me your age. What is the first video game you played? GIFS ONLY!!!

@chandrarsrikant Perplexity ✅ Chatgpt ✅ Gemini ✅ What next? 😅

Reliance ties up with Google to offer Gemini Pro plan free to some Jio users for 18 months moneycontrol.com/news/business/…

@Zephyr_hg News

I never run out of content to post anymore. Built an automation that monitors 50+ news sources, scores articles for relevance, and writes social posts automatically. It finds trending topics in my niche before they explode everywhere else. Saves me 15-20 hours monthly and keeps me ahead of every trend. Comment "NEWS" and I'll DM it to you (must be following)

@Rahul_J_Mathur With the products being sold largely non-branded, i think Meesho may have a good scope to increase its take rate.. with a low cost structure, seller margin must be decent enough to let Meesho get better take rates if it can funnel enough buyers for the sellers

(2) Scale economies are somewhat questionable….. (my only bear case on this business) (a) The cost per order is down to ~₹37 in Q1 FY26 from ~₹50 in FY23 👍 Awesome, right? (b) Well, not really - because AOV has also come down! (c) As a % of AOV - cost per order is ~13.7% v/s 15% in FY23 - not much has changed… This actually flows into the Contribution Margin - it remains at ~4.5% in Q1 FY26 v/s the peak ~5.6% in FY24. Now, I’d also highlight that the bull case here is - AOV decline will plateau and as Meesho moves from 60% Valmo orchestration to ~80%+ orchestration (plus some further tweaks) - this should work just fine (if it doesn’t, don’t ask me).

Meesho clocked ₹30,000 crore of Sales in FY25 - this is approx. 30 lakh orders per day fulfilled by 5 lakh sellers! They aim to raise ~₹6,500 crore in their upcoming IPO; and it is the first horizontal e-commerce platform to go public in India (Flipkart started 8 years prior btw!) Meesho’s updated 667 page DRHP is a must read for anyone who follows E-Commerce in India Here are my 5 key takeaways from the filings⤵️

@asikdas They*.. meant to refer to iPlanet

@Ankur_C “You” and “thy” refer to the same person

Dear @Apple, your reseller in india @iPlanetOfficial did not give me an invoice for the airpods i bought today citing mfg “server issues” and after i chased them for it, their employee sent an invoice (not sure if it’s original) via his personal whatsapp.

@dr_ericberg Eggs

What’s your favorite healthy breakfast option?