EWAS Atlas

Very happy to announce that I will be opening my lab at the Genome Institute of Singapore @astar_gis in February 2023! Looking forward to joining the outstanding group of scientists at GIS stuartlab.org

Learn how to integrate 1.4 million B/plasma cells from 1400+ samples by FastIntegration!!! #SingleCell #Bcell tinyurl.com/522zzk2z

All DISCO data has migrated to a new server!!! The data download speed is much faster than before. We have also uploaded h5ad data for each atlas now. Try at immunesinglecell.org/download #scRNAseq #singleCell #bioinformatics

#SingleCell DISCO: Deep Integration of Single-Cell Omics. Want to visual millions of cell online and annotate cell type automatically? Try it!!! Make single cell easier and make life easier! #DISCO #Cell #Immune immunesinglecell.org

#SingleCell DISCO: Deep Integration of Single-Cell Omics immunesinglecell.org

The 2019 Novel #Coronavirus Resource in China National Center for Bioinformation (#NGDC) integrates 18,647 genome sequences of #2019nCoV and provides various visualization and analysis functionalities to support the research on #2019nCOV. Learn more: bigd.big.ac.cn/ncov/

Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic platform, both recently published in @NatureComms : nature.com/articles/ncomm… & nature.com/articles/s4146…

First first-author paper is out! Our key findings follow. nature.com/articles/s4152…

New #EWAS on maternal #BloodPressure During #Pregnancy #DNAmethylation ahajournals.org/doi/abs/10.116…

Effect of early parenteral nutrition during paediatric critical illness on DNA methylation as a potential mediator of impaired neurocognitive development: a pre-planned secondary analysis of the PEPaNIC international randomised controlled trial sciencedirect.com/science/articl…

Maternal circadian disruption is associated with variation in placental DNA methylation. ncbi.nlm.nih.gov/pubmed/3102630…

Excited to share the first publication resulting from my PhD data. We explore the reproducibility of #ewas findings in an African study population. Three years in the making! 🎉😁 Co-authored by @hannah_elliott. #phdchat #gettingthere #epitwitter …lepigeneticsjournal.biomedcentral.com/articles/10.11…

A new #EWAS using phosphatidylethanol(PEth) as the measure of alcohol consumption found 83 blood PEth associated DNAs. nature.com/articles/s4138… EWAS Atlas link: bigd.big.ac.cn/ewas/browse?tr…

Integrated with #metabolomics and #transcriptomics CpG-associations and disease links from @AtlasEwas complex functional networks emerge.

New research: A Diagnostic Panel of DNA Methylation Biomarkers for Lung Adenocarcinoma: Lung adenocarcinoma (LUAD) is one of the most common cancers and lethal diseases in the world. Recognition of the undetermined lung nodules at an early… frontiersin.org/articles/10.33… #oncology

New today! Aberrant DNA methylation underlies several human disorders. Now, Beck et al. describe a rare disease caused by altered DNA demethylation bit.ly/2t1mWYf

Study finds 75% of umbilical cord DNA to be hypermethylated in utero when exposed to arsenic. ncbi.nlm.nih.gov/pmc/articles/P… #me #DNAmethylation #toxin #endocrinology #arsenic #nutritionalepigenetics

Specifically, she looked at the gene DLGAP2, which showed significant changes in DNA methylation among user/exposure groups for both men and male rats. DLGAP2 is thought to have some role in disorders such as autism. tandfonline.com/doi/full/10.10…

"Entering the post-epigenomic age: back to epigenetics" - commentary from Sebastian Bultmann and Stefan Stricker, proposing widespread follow-up use of epigenome editing technology in #EWAS studies #GenSoc100 ow.ly/7SAv50xbPS0 #OpenBiology