Audra Iness, MD, PhD

We are excited to announce the release of the Human Methylation Atlas Summary and Signals tracks for hg38 and hg19. The tracks display genome-wide DNA methylation profiles across 39 primary human cell types from 205 healthy tissue samples. Learn more at bit.ly/humanMethylati…

Happening Now! Tonight we’re joined by Dr. Danielle Sawyers, (@DanielleSawyer_), Dr. Audra Iness (@AudraIness), and Dr. Judy Wang to discuss Funding Your Future: F30 Fellowship. Stay tuned for live updates! #APSAWebinar

What does a Medical Geneticist do? We work at the intersection of medical practice & scientific discovery—because each genome is unique. We collaborate w/ physicians, counselors, diagnostic labs, patients, & advocates to turn these discoveries into medically actionable insights

I recently had the pleasure of meeting colleagues @ChildrensNatl as part of the Rare Disease Clinical Scholars Program. Rare diseases show us that meaningful intervention is not only necessary—but possible—even for N=1. Looking forward to advancing precision medicine together.

@morgancheatham Thank you for the encouragement, @morgancheatham! Big congrats on your new role and wishing you all the best as you start residency. You’re going to do amazing—you already are! ☺️

@AudraIness you are the goat! 🐐

I am also grateful to the patients and families who have taught me and allowed their stories to be shared, so we can all continue learning and growing. There is still so much we do not know — and may never fully understand — but we show up and do our best every day.

2 posters, 1 mission: mitochondrial precision medicine 🧬 Single-cell NUMT detection pipeline 🩺 Severe dengue in mitochondrial disease Honored to be a scholarship awardee & stand at the intersection of the bench & bedside. Thank you @UMDF for an excellent #MitoMed 2025!

See one. Do one. Teach one. Make one.

Grateful to have been part of the AAP/ASCI/APSA Joint Meeting—this time as a @BCM_Pediatrics and @bcmgenetics representative, mentor, and past @A_P_S_A president. Honored to join leaders across the physician-scientist community, including @LaskerFDN.

Interesting how evolution favors redundancy, but I’ve never understood why we have 2 active kidneys—both simultaneously vulnerable to injury. Why not 1 functional kidney, & 1 metabolically dormant backup, ready in case the 1st fails? Just seeing too many failed kidneys lately.

Humans are impressively adaptable.

Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at satijalab.org/scgd25

I always feel a bit conflicted diagnosing a rare disease. On one hand, I’m providing an answer. On the other, I’m introducing a new set of questions. There’s still so much we don’t know in medicine—but what I do know is I’m dedicated to figuring it out. Back to the lab! 🧫

Wanted to share my thoughts on 23andMe from the medical genetics perspective. Genetic testing as a whole is more complex than most realize: open.substack.com/pub/audrainess…

Congratulations to all the incoming residents this Match Day!

@Jason Curious to hear the outcome of your experiment, @Jason! It was great meeting you at the recent All-In Live event in Austin. Looking forward to the Summit!

I’m in the process of lowering my subscription rate to $1 a month — 100% to charity All current subs will drop down to that rate as we try to reach 10,000 contributors Also, I will have “ed the intern” unsubscribe from folks who don’t contribute so I can follow subscribers back (it’s not personal, it’s an experiment)

Medicine has taught me making a decision is better than making no decision.

NIH is centralizing peer review of all applications for grants, cooperative agreements and research and development contracts within the agency’s @CSRpeerreview. This is expected to save NIH more than $65 million annually & make the review process more efficient. go.nih.gov/iGmUyfH

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on April 25. Talks will feature recent exciting computational and experimental advances and will be live-streamed at satijalab.org/scgd. Please RT/spread the word!

There’s a profound difference between waiting to ‘make it’ and actively ‘making it happen.’ True agency lies in proactively shaping your experiences rather than passively accepting your circumstances. Thank you, @A_P_S_A, for this realization. jci.org/articles/view/…